Navigation Links
Lorus Therapeutics Announces Publication of a Clinical Study Demonstrating Encouraging Results with LOR-2040 in Combination with Cytarabine in Patients with Acute Myeloid Leukemia (AML)
Date:7/2/2008

- Study also points to potential of pre-treatment R2 levels as a possible

predictor of clinical activity -

TORONTO, July 2 /PRNewswire-FirstCall/ - Lorus Therapeutics Inc. (TSX: LOR, AMEX: LRP) ("Lorus" or the "Corporation"), a biopharmaceutical company specializing in the research and development of pharmaceutical products and technologies for the management of cancer, today announced publication by an Ohio State University (OSU) clinical team of a paper entitled "Phase I Study of GTI-2040, an Antisense to Ribonucleotide Reductase, in Combination with High-Dose Cytarabine in Patients with Acute Myeloid Leukemia" (Clinical Cancer Research 2008; 14 (12): 3889-3895). This was the first clinical study in AML with GTI-2040, now known as LOR-2040.

The primary author, Dr Rebecca Klisovic and the Principal Investigator, Dr Guido Marcucci, in the Division of Hematology and Oncology at OSU carried out the study under the sponsorship of the National Cancer Institute (NCI) Cancer Therapy Evaluation Program (CTEP). Lorus is collaborating with the Division of Cancer Treatment and Diagnosis, NCI on the development of LOR-2040 under a Clinical Trials Agreement. All patients in the study received LOR-2040 and high dose cytarabine in therapeutic doses within a dose escalating design, which determined a well-tolerated recommended Phase II dose.

In this study, the authors examined the relationship of the targeted activity of LOR-2040 to clinical responses in AML patients less than 60 years of age. Downregulation of R2, the target of LOR-2040, after 24 hours of LOR-2040 was statistically significant and was associated with complete remission. The authors have also now reported for the first time that outcomes of complete response were associated with high pre-treatment levels of R2, which were statistically significant compared to nonresponders. This finding suggests that pre-treatment R2 levels may be a predictor of response, and provid
'/>"/>

SOURCE Lorus Therapeutics Inc.
Copyright©2008 PR Newswire.
All rights reserved

1

GOOD

Page: 1 2 3 4 5

Related biology technology :

1. Lorus Advances Clinical Development of GTI-2040 Combined with Ara-C in Acute Myeloid Leukemia
2. Lorus Therapeutics Appoints Peter Korth as Chief Financial Officer
3. Lorus Therapeutics Announces Exclusive Multinational License Agreement with Zoticon Bioventures for Virulizin(R)
4. Lorus Therapeutics presents new findings for the anticancer drugs LOR-253 and LOR-2040
5. Lorus initiates development program exploring novel route of administration for LOR-2040
6. Lorus Therapeutics Strengthens Its Senior Management Team Through Internal Promotions
7. Vicus Therapeutics to Present at the 234th American Chemical Society National Meeting in Boston, MA
8. DJO Incorporateds Pending Merger With ReAble Therapeutics Clears U.S. Antitrust Review
9. PeriCor Therapeutics Announces Closing of Licensing Agreement for Acadesine with Schering-Plough Corporation
10. Systems Medicine (SM), a Subsidiary of Cell Therapeutics, Inc. (CTI), Announces Execution of CRADA with NCI/NIH to Develop Potential Cancer Treatments Targeting the Insulin Growth Factor (IGF) Pathway
11. Amsterdam Molecular Therapeutics to Release H1 2007 Results on August 29, 2007

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/25/2009)... , ,, BOCA RATON, Fla., Nov. 25 /PRN...ainful year. Not so for BodyLogicMD. The nation,s...sicians specializing exclusively in medically supe...er of physicians in its network since Novemb...ogress to add more physician-owned centers, includ...
(Date:11/25/2009)...NEW YORK, Nov. 25 Reportlinker.com...ailable in its catalogue: ,, Brazil Bioethanol...p://www.reportlinker.com/p0165503/Brazil-Bioethano..., Brazil Bioethanol Market Analysis and Forecasts ...detailed analysis and forecasts of the global bioe...
(Date:11/24/2009)...USTON, Nov. 24 IES (Nasd...ical and communications systems and services for t... announced today that its commercial business grou...n JV to install the electrical systems for the Lev...t the U.S. Army Medical Research Institute of Infe...
(Date:11/24/2009)...NTA CRUZ, Calif., Nov. 24 Two more...enter, the nation,s leading online job board and c...Northwestern and Columbia University are now membe...cience training Institutions. ,, The job board,...ates in the life sciences. While there are hundred...
Breaking Biology Technology:Nation's Largest Network of Doctors Specializing in Bioidentical Hormones Grows at an Exponential Rate 2Nation's Largest Network of Doctors Specializing in Bioidentical Hormones Grows at an Exponential Rate 3Nation's Largest Network of Doctors Specializing in Bioidentical Hormones Grows at an Exponential Rate 4Reportlinker Adds Brazil Bioethanol Market Analysis and Forecasts to 2013 2Reportlinker Adds Brazil Bioethanol Market Analysis and Forecasts to 2013 3Reportlinker Adds Brazil Bioethanol Market Analysis and Forecasts to 2013 4Reportlinker Adds Brazil Bioethanol Market Analysis and Forecasts to 2013 5Reportlinker Adds Brazil Bioethanol Market Analysis and Forecasts to 2013 6Reportlinker Adds Brazil Bioethanol Market Analysis and Forecasts to 2013 7Reportlinker Adds Brazil Bioethanol Market Analysis and Forecasts to 2013 8Reportlinker Adds Brazil Bioethanol Market Analysis and Forecasts to 2013 9Reportlinker Adds Brazil Bioethanol Market Analysis and Forecasts to 2013 10Integrated Electrical Services Awarded Contract to Provide Electrical Systems for U.S. Army Medical Research Institute of Infectious Diseases 2Two Major Universities Join Nation's Leading Postgrad Bio Job Board 2
...dingBlocks is market,s first service for pre-purch..., Dec. 9 The Scientific business of Thomson Reute... source for online access to industry codes and st... BuildingBlocks utility, allowing engineers to pre...hers such as ASTM (American Society for Testing a...
...H SAN FRANCISCO, Calif., Dec. 9 Proteolix, Inc. t...g that the company,s lead,product, carfilzomib, ha...nses,in patients with relapsed and refractory mult...lass of specific proteasome inhibitors being devel... malignancies and solid tumors. , Sundar Jag...
...TO, Calif., Dec. 9 BioMarin Pharmaceutical,Inc. (...Merck Serono, a division,of Merck KGaA, Darmstadt,...n(R) (sapropterin dihydrochloride) for the treatme...ia (PKU) or BH4 deficient patients,from the Europe...are,approximately 35,000 patients diagnosed with h...
Other Biology Technology:Techstreet Launches BuildingBlocks Utility for Industry Standards Saving Time and Increasing Productivity for Engineers 2Proteolix Announces Positive Data From Two Ongoing Phase 2 Clinical Trials of Carfilzomib in Multiple Myeloma at the 50th Annual Meeting of the American Society of Hematology 2Proteolix Announces Positive Data From Two Ongoing Phase 2 Clinical Trials of Carfilzomib in Multiple Myeloma at the 50th Annual Meeting of the American Society of Hematology 3Proteolix Announces Positive Data From Two Ongoing Phase 2 Clinical Trials of Carfilzomib in Multiple Myeloma at the 50th Annual Meeting of the American Society of Hematology 4Proteolix Announces Positive Data From Two Ongoing Phase 2 Clinical Trials of Carfilzomib in Multiple Myeloma at the 50th Annual Meeting of the American Society of Hematology 5Proteolix Announces Positive Data From Two Ongoing Phase 2 Clinical Trials of Carfilzomib in Multiple Myeloma at the 50th Annual Meeting of the American Society of Hematology 6Kuvan Receives Marketing Approval in the European Union 2Kuvan Receives Marketing Approval in the European Union 3Kuvan Receives Marketing Approval in the European Union 4
(Date:11/24/2009)...arctica has long held secrets of the earth,s histo...here has been very little information on the envir... for millions of years. Now, a team of researchers...funded to the tune of $10 million dollars by the N...bottom of things literally. These scientists will...
(Date:11/24/2009)...vember 24, 2009) New research on bacterial commun... reveals predictable temporal patterns, suggesting...rkers for monitoring climate change in the polar r...ceedings of the National Academy of Sciences Earl... six rivers shifted synchronously over time, corre...
(Date:11/23/2009)...arch presents strong evidence that the "synergisti...raffic-related pollution and indoor endotoxin caus...ther exposure alone. , Environmental health sc...ege of Medicine have shown that children exposed t...d indoor endotoxin during early life are six times...
Breaking Biology News(10 mins):LSU gets to the bottom of things -- in Antarctica 2Researchers establish common seasonal pattern among bacterial communities in Arctic rivers 2Exposure to both traffic, indoor pollutants puts some kids at higher risk for asthma later 2Bioterrorism and disaster preparedness explored in special issue of Medical Decision Making 9378 1Bioterrorism and disaster preparedness explored in special issue of Medical Decision Making 9378 2As Good As a Deli For the Price of Making It At Home 52824 1As Good As a Deli For the Price of Making It At Home 52824 2Molecule plays early role in nonsmoking lung cancer 52821 1Molecule plays early role in nonsmoking lung cancer 52821 2
...that interfere with the action of one particular e...roblems led scientists at Johns Hopkins to create ...w them to see multiple, real-time chemical reacti...ublished July 21 in the journal ACS Chemical Biolo...est chemicals on enzymes isolated from their norma...
...enetic material intact, scientists at Johns Hopkin... vital to managing a yeast cell,s energy. They dis...l of one of them led the cell to turn off 70 perce...ely unprepared for such a dramatic event," says Je...ology and genetics at Hopkins and author of the st...
...ads of Earthlings, arrays of single-cell creatures...le devices are riding on the International Space S...nd the University of New Mexico, NASA and US Air F...ons were directed by yeast and other single cells ... even in the vacuum and radiation of outer space -...
Other Biology News:Hopkins researchers develop new tool to watch real-time chemical activity in cells 2Hopkins researchers develop new tool to watch real-time chemical activity in cells 3Johns hopkins researchers find link between cell's energy use and genome health 2Johns hopkins researchers find link between cell's energy use and genome health 3Sandia work launched on space shuttle shows live cells influence growth of nanostructures 2Sandia work launched on space shuttle shows live cells influence growth of nanostructures 3Sandia work launched on space shuttle shows live cells influence growth of nanostructures 4Sandia work launched on space shuttle shows live cells influence growth of nanostructures 5
Mouse Anti-Human MYO7A Monoclonal Antibody, Unconjugated, Clone 1D3 from Abnova Corporation
..., Functionally-Validated, Ion Channel Cell Lines ...l role in nerve and muscle function and consequent... Drugs that modulate ion channels have been invest...ain, cardiac arrhythmia, hypertension, local anaes...
Mouse Anti-Human TTC3 Monoclonal Antibody, Unconjugated, Clone 2D10 from Abnova Corporation
Mouse Anti-Human SYT4 Polyclonal Antibody, Unconjugated from Abnova Corporation
Biology Products: