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LoneStar Heart Acquires Worldwide Exclusive Rights to New Class of Small Molecules That May Lead to New Treatments for Diabetes
Date:1/16/2012

reting insulin, the hormone that controls the level of glucose in the blood. Preliminary experiments in mice indicate the compounds have little toxicity. "Isoxa­zole is among relatively few single molecules known that can improve beta-cell function dramatically," the study concludes.

Diabetes is a group of metabolic diseases in which a person has high blood sugar, either because the body does not produce enough insulin (type 1 diabetes), or because cells do not respond to the insulin that is produced (type 2 diabetes). More than one-third of the U.S adult population is at risk for type 2 diabetes, the most prevalent form of the disease. During the development of type 2 diabetes, beta cells become progressively unable to produce insulin, causing the blood sugar to rise dangerously, leading to increased risk of heart attacks, strokes, diabetic retinopathy where eye sight is affected, and kidney failure.

The research is part of LoneStar Heart's broad program of developing small molecules and proteins that have the capacity to switch native, cardiac stem cells into adult heart muscle cells as a means of restoring and repairing damaged heart tissue. These mechanisms are typically repressed in adult hearts injured by myocardial infarction, advanced age, and other diseases.

About LoneStar Heart Inc.

LoneStar Heart Inc. is developing cardiac restorative therapies for patients with heart fail­ure that harness the heart's ability to repair itself. Based on its integrated cardiomechanical and biomolecular technologies, the privately held company is advancing a broad portfolio of pro­ducts to restore the failing heart's structure and function in collaboration with the Texas Heart Institute, UT Southwestern, and a global network of leading clinicians. These products include Algisyl-LVR™, cardiac stem-cell modulators, and cellular and genetic therapies delivered as stand-alone treatments, or in combination with the co
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SOURCE LoneStar Heart Inc.
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