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LoneStar Heart Acquires Worldwide Exclusive Rights to New Class of Small Molecules That May Lead to New Treatments for Diabetes
Date:1/16/2012

LAGUNA HILLS, Calif., Jan. 16, 2012 /PRNewswire/ -- LoneStar Heart Inc., based here, today announced that it has acquired a worldwide exclusive license from the University of Texas Southwestern Medical Center (UT Southwestern) to commercialize a new class of patented small molecules known as Isoxazoles that markedly increase insulin production in human pancreas cells no longer able to produce insulin. Activating the entire biochemical pathway involved in insulin production, the molecules may represent a new approach to developing treatments for both type 1 and type 2 diabetes. The terms of the agreement were not disclosed.

"Our exclusive license with UT Southwestern builds upon previous licensing agreements with broad coverage for the small molecules involved," explained Frank Ahmann, president and chief operating officer of LoneStar Heart Inc. "Research at UT Southwestern has shown that, in addition to their potential application to diabetes, they may also modulate the differentiation of stem cells into nerve cells, and they can induce a population of progenitor cells found in the heart to become cardiac muscle cells." Progenitor cells are a type of adult stem cell that is further differentiated toward becoming its target cell, and act as a repair system for the body.

Small Molecules Provide Dramatic Improvement in Malfunctioning Pancreas Cells

As reported in the December 20, 2011 issue of the journal, Proceedings of the National Academy of Sciences of the United States of America (PNAS), the research was conducted by Elhadji Dioum Ph.D. and other UT Southwestern researchers led by Jay W. Schneider, M.D., Ph.D., assistant professor of cardiology and internal medicine, and professor Melanie H. Cobb, Ph.D. They showed Isoxazoles were able to induce insulin expression in human beta cells two-to-twelve months old that progressively lose their ability to produce insulin. Beta cells of the pancreas are responsible for sec
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SOURCE LoneStar Heart Inc.
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