| HOME >> BIOLOGY >> TECHNOLOGY |
EAST SETAUKET, N.Y., April 4, 2012 /PRNewswire/ -- Lixte Biotechnology Holdings, Inc. announced receiving an official notice of allowance from the United States Patent and Trademark Office for its lead histone deacetylase inhibitor (HDACi), LB-201 and other structural homologs.
Dr. John Kovach, founder and president of Lixte, said, "Although there are HDACi approved for certain types of skin lymphomas and many other HDACi in various stages of development, our compounds have characteristics which may be advantageous for clinical use. The Lixte compounds also have broad anti-cancer activity but in addition have 1) potential for the treatment of neurodegenerative diseases, for which Lixte recently announced a USPTO patent approval, 2) activity (LB-205) against the lysosomal storage disease, Gaucher Disease, as recently reported in the Proceedings of the National Academy of Science, USA (Dec. 27 2011; 108:21200-5) and 3) curative anti-fungal activity applied topically (LB-201) against the most common skin fungal infections of humans and domestic animals in guinea pig models. As Lixte is predominantly focused on cancer treatment, it is seeking to license the non-neoplastic activities of its proprietary HDACi."
Dr. Kovach continued, "Lixte's primary goal at present is bringing its lead anti-cancer compound, LB-100, into Phase I trial. We believe this inhibitor of serine/threonine phosphatase has the potential to be first-in-class and to have wide applicability for the treatment of diverse cancers. LB-100 has completed pre-clinical toxicology and formulation with an anticipated IND submission for FDA approval of a Phase I trial this spring."
About Lixte Biotechnology Holdings, Inc.
Lixte is a cancer drug discovery company, combining selection of novel targets from the medicinal chemistry and molecular biology literature with innovative synthetic chemistry to develop new potentially more effective anti-cancer drugs. It has l
'/>"/>
| SOURCE Lixte Biotechnology Holdings, Inc. Copyright©2010 PR Newswire. All rights reserved |
Related biology technology :
1. Lixte Biotechnology Holdings Announces New Appointment to Board of Directors
2. Lixte Biotechnology Holdings Lead Compound, LB-1.2, Enhances the Effectiveness of Standard Cancer Chemotherapy in Animal Models
3. Lixte Biotechnology Holdings Announces New Appointment to Board of Directors
4. Lixte Biotechnology Holdings Announces Filing of a New Patent Application for Cancer Therapy Based on Targeting a Biomarker by Novel Investigational Agents
5. Apexigen and Shanghai Duyiwei Biotechnology Co. Ltd Sign a License and Collaboration Agreement to Develop and Commercialize APX004
6. Global Biotechnology Industry
7. JumpStart Invests $250,000 in Milo Biotechnology
8. Puma Biotechnology Announces Positive PB272 (Neratinib) Phase II Data at CTRC-AACR San Antonio Breast Cancer Symposium
9. The European Union Signs Grant Contract to Fund a 2 Million Euro Biotechnology Research Project Led by Hadassah College Jerusalem
10. Animal Biotechnology - Technologies, Markets and Companies
11. Puma Biotechnology Announces Completion of Private Placement
| Copyright © 2003-2012 Bio-Medicine. All rights reserved. ABOUT | CONTACT US | DISCLAIMER | PRIVACY POLICY | TERMS AND CONDITIONS |  |