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Lixte Biotechnology Holdings Announces Extension of Its Cooperative Research and Development Agreement With The National Institute of Neurological Disorders and Stroke, National Institutes of Health, for Development of Anti-Brain Cancer Drugs
Date:6/25/2008

EAST SETAUKET, N.Y., June 25 /PRNewswire-FirstCall/ -- Lixte Biotechnology Holdings (OTC Bulletin Board: LIXT) announced today that the National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH) and Lixte Biotechnology Holdings, Inc. extended their Cooperative Research and Development Agreement (CRADA) to develop drugs for the treatment of brain cancers. The CRADA, initiated in March 2006 was extended through September 2009.

Dr. John S. Kovach, President and CEO of Lixte, said, "The scientific interaction with the research team at the Molecular Pathogenesis Unit (MPU), Surgical Neurology Branch, (SNB), NINDS, has been highly productive and is a good example of how government and private sector scientific organizations may accelerate the drug development process. A novel biomarker of glioblastoma multiforme, the most common and aggressive brain tumor of adults, discovered at the MPU, SNB led to insights into potential vulnerability of this devastating cancer to pharmacologic attack. Based on these insights, Lixte synthesized two different types of anti-cancer drugs that target the biomarker. In less than two years, working with the MPU, SNB under the CRADA, Lixte has identified lead compounds of both types, which inhibit glioblastoma multiforme in animal models. These novel compounds are now undergoing pre- clinical evaluation of their pharmacologic characteristics, the first step in the process of preparing an Investigational Drug Application (IND) to the FDA for clinical evaluation."

About Lixte Biotechnology Holdings, Inc.:

Lixte Biotechnology Holdings, Inc. is a cancer therapeutics and diagnostics company. Founded as a biomarker-diagnostics company in 2005, Lixte develops new chemotherapy drugs targeting molecular abnormalities of common human cancers.

About the National Institute of Neurological Disorders and Stroke (NINDS), (NIH):

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SOURCE Lixte Biotechnology Holdings, Inc.
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