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Lixte Biotechnology Holdings, Inc. Announces the Initial Trading of Its Common Stock Under the Symbol: LIXT
Date:9/24/2007

in life span measured in months. Thus, there is an urgent need for more effective treatments for this disease.

Over the next year, as part of its collaboration with NIH, the company will complete the determination of the effectiveness of lead compounds from each of two different classes of drugs developed by Lixte that are active against GBM in the test tube. Initial studies showed that two different compounds have anti-tumor activity in a mouse model. The next steps will be detailed characterization of the anti-tumor activity of these drugs in animal models of human GBM and description of their pharmacologic behavior and metabolism. Subsequently, the toxicity profiles of active drugs will be determined in pre-clinical toxicology studies. Should the results of the foregoing tests and studies prove successful, we hope to satisfy all requirements of the FDA for approval of, at least, one lead compound for evaluation in Phase I trials in late 2008 or early 2009. Lixte will also evaluate the anti-cancer activity of its new compounds against two life- threatening cancers of children, neuroblastoma and medulloblastoma, and against several common cancers of adults in addition to GBM.

About the National Institute of Neurological Disorders and Stroke (NINDS), (NIH):

NINDS (http://www.ninds.nih.gov) is a component of the National Institutes of Health (NIH), and is the nation's primary supporter of biomedical research on the brain and nervous system.

The National Institutes of Health (NIH) - The Nation's Medical Research Agency - includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. It is the primary federal agency for conducting and supporting basic, clinical and translational medical research, and it investigates the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit

SOURCE Lixte Biotechnology Holdings, Inc.
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