Navigation Links
Lilly to Acquire ImClone Systems in $6.5 Billion Transaction
Date:10/6/2008

of 1373 patients receiving ERBITUX in clinical trials. Severe acneform rash occurred in 1-17% of patients

- Acneform rash usually developed within the first two weeks of therapy and resolved in a majority of the patients after cessation of treatment, although in nearly half, the event continued beyond 28 days

- Monitor patients receiving ERBITUX for dermatologic toxicities and infectious sequelae
- Sun exposure may exacerbate these effects

ERBITUX plus Radiation Therapy and Cisplatin

-- The safety of ERBITUX in combination with radiation therapy and cisplatin has not been established

- Death and serious cardiotoxicity were observed in a single-arm trial with ERBITUX, radiation therapy, and cisplatin (100 mg/m2) in patients with locally advanced squamous cell carcinoma of the head and neck

- Two of 21 patients died, one as a result of pneumonia and one of an unknown cause

- Four patients discontinued treatment due to adverse events. Two of these discontinuations were due to cardiac events

Electrolyte Depletion

-- Hypomagnesemia occurred in 55% (199/365) of patients receiving ERBITUX and was severe (NCI CTC grades 3 & 4) in 6-17%. The onset of hypomagnesemia and accompanying electrolyte abnormalities occurred days to months after initiation of ERBITUX therapy

- Monitor patients periodically for hypomagnesemia, hypocalcemia and hypokalemia, during, and for at least 8 weeks following the completion of, ERBITUX therapy
- Replete electrolytes as necessary

Late Radiation Toxicities

-- The overall incidence of late radiation toxicities (any grade) was higher with ERBITUX in combination with radiation therapy compared with radiation therapy alone. The following sites were affected: salivary glands (65%/56%), larynx (52%/36%), subcutaneous tissue (49%/45%), mucous membranes (48%/39%), esophagus (44%/35%), and skin (42%/33%) in the ERBITUX and radiation versus radia
'/>"/>

SOURCE Eli Lilly and Company
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16

Related biology technology :

1. Covance and Lilly Finalize 10-Year, $1.6 Billion Strategic R&D Collaboration
2. BioMS Medical announces receipt of milestone payment from Eli Lilly and Company
3. Amylin Pharmaceuticals and Eli Lilly Provide Context for FDA Alert for BYETTA
4. Amylin and Lilly Set Date and Time for Conference Call
5. Lilly Announces Completion of SGX Acquisition
6. SGX - Lilly Merger Offer Receives Positive Opinions From Proxy Advisory Firms
7. Lilly Reaffirms Purchase Offer for SGX Pharmaceuticals
8. Lilly Reports Solid Second-Quarter Results
9. Lilly to Acquire SGX Pharmaceuticals
10. Lillys Connelly Appointed to the Presidents Commission on White House Fellowships
11. Lilly Employees from Nearly 50 Nations Participate in Companys First-Ever Global Day of Service
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/15/2014)... , Sept. 15, 2014   Global Science ... of scientific products and services for satellite and ... Solution for Integrated Services (OASIS) from the General ... was selected to provide the government best-value solutions ... Business (SB) category in Pool 4. The OASIS ...
(Date:9/15/2014)... SYDNEY , Sept. 15, 2014 ... focused on revolutionizing the treatment of cancer through ... cancer cells, announced that, together with the Asbestos ... 2014 Cancer Institute New South Wales (NSW) Premier,s ... other four recipients are the hospitals that will ...
(Date:9/15/2014)... developed a technique for controlling the surface tension of ... door to a new generation of reconfigurable electronic circuits, ... fact that the oxide "skin" of the metal ... a surfactant, lowering the surface tension between the metal ... liquid metal alloy of gallium and indium. In base, ...
(Date:9/15/2014)... very idea of fibers made of carbon nanotubes is neat, ... , The single-walled carbon nanotubes in new fibers created at ... a process designed by chemist Angel Mart and his colleagues. ... its results this month in the journal ACS Nano ... drawn together into a fiber. , Left to their own ...
Breaking Biology Technology:Global Science & Technology, Inc. Awarded GSA OASIS Small Business Contract 2Global Science & Technology, Inc. Awarded GSA OASIS Small Business Contract 3EnGeneIC Named a Recipient of the Cancer Institute NSW Premier's Award for Excellence in Translational Cancer Research 2EnGeneIC Named a Recipient of the Cancer Institute NSW Premier's Award for Excellence in Translational Cancer Research 3Researchers control surface tension to manipulate liquid metals 2Rice rolls 'neat' nanotube fibers 2Rice rolls 'neat' nanotube fibers 3
... Renowned actor and martial artist Steven Seagal has written ... the Prime Minister,s support of the "Russia 2045" movement that ... body research. According to Seagal, "Russia 2045," by using and ... life and make humans immortal by the year 2045. ...
... a new measure of response to RA treatment ... sensitivity compared to traditional ACR responses, according to recently published ... and DAS28 scores were compared to the ACR hybrid score ... first clinical trial data to be analyzed using the ACR ...
... (slow down) in a well-understood linear manner, but ground-breaking ... at the Catalan Institute of Nanotechnology has shown that ... nonlinear damping, opening up exciting possibilities for super-sensitive detectors ... be published in Nature Nanotechnology (DOI - ...
Cached Biology Technology:Steven Seagal Asks For Russian PM Vladimir Putin's Support in Immortality Research 2Novel ACR Hybrid Score in Rheumatoid Arthritis Applied for the First Time to Data from the RAPID 1 Study with Cimzia® (certolizumab pegol) 2Novel ACR Hybrid Score in Rheumatoid Arthritis Applied for the First Time to Data from the RAPID 1 Study with Cimzia® (certolizumab pegol) 3Novel ACR Hybrid Score in Rheumatoid Arthritis Applied for the First Time to Data from the RAPID 1 Study with Cimzia® (certolizumab pegol) 4Novel ACR Hybrid Score in Rheumatoid Arthritis Applied for the First Time to Data from the RAPID 1 Study with Cimzia® (certolizumab pegol) 5Novel ACR Hybrid Score in Rheumatoid Arthritis Applied for the First Time to Data from the RAPID 1 Study with Cimzia® (certolizumab pegol) 6Novel ACR Hybrid Score in Rheumatoid Arthritis Applied for the First Time to Data from the RAPID 1 Study with Cimzia® (certolizumab pegol) 7Novel ACR Hybrid Score in Rheumatoid Arthritis Applied for the First Time to Data from the RAPID 1 Study with Cimzia® (certolizumab pegol) 8Novel ACR Hybrid Score in Rheumatoid Arthritis Applied for the First Time to Data from the RAPID 1 Study with Cimzia® (certolizumab pegol) 9Exotic behavior when mechanical devices reach the nanoscale 2
(Date:9/15/2014)... Earth for the first 500 million years after it ... day, complete with oceans, continents and active crustal plates. ... called the Hadean, has gained substantial new support from ... more than 4 billion years ago with those formed ... possible geological analog for early Earth. , The study ...
(Date:9/15/2014)... genes that affect hearing and cognitive function may play ... understand and perceive rhythm, pitch, timbre, tone durations, and ... BioEssays article explain that extremes in musical ... with the majority of individuals having moderate aptitude. , ... attributable to several underlying genes, and it is influenced ...
(Date:9/15/2014)... evolution experiment scientists from GEOMAR Helmholtz Centre for ... Sea Fisheries have demonstrated for the first time, ... the world,s oceans, Emiliania huxleyi , can ... temperatures. In their study, the researchers found no ... to these two aspects of climate change would ...
Breaking Biology News(10 mins):Early Earth less hellish than previously thought 2Early Earth less hellish than previously thought 3Small algae with great potential 2Small algae with great potential 3
... biological process that supports life on earth. Plants and ... their food, and in the process, also provide vital ... international collaboration between Arizona State University, the University of ... has come up with a surprising twist to photosynthesis ...
... world,s largest river deltas to the global oceans have ... as a result of human activity, says a Texas ... that can be gathered from sediment cores collected in ... a better understanding of environmental changes in the 21st ...
... in avian conservation is underway this spring throughout the ... A legion of highly skilled volunteer ornithologists is helping ... sites for migrating birds in the southern coastal zone ... migrants. These songbirds summer in the subarctic part of ...
Cached Biology News:Pliable proteins keep photosynthesis on the light path 2Pliable proteins keep photosynthesis on the light path 3Pliable proteins keep photosynthesis on the light path 4River delta areas can provide clue to environmental changes, Texas A&M prof says 2River delta areas can provide clue to environmental changes, Texas A&M prof says 3Conservationists seek to identify prime stopover sites for migrating birds 2Conservationists seek to identify prime stopover sites for migrating birds 3
... The OneSTrEP Protein Interaction Kit ... single step method to isolate intact ... require tedious optimization or multiple purification ... the highly selective StrepTactin Superflow Column ...
Request Info...
... The system consists ... (Cat. No. 17001-082) and ... 17002-080). It is complete ... promoting agents, and requires ...
... 5 ml Dynabeads Tosylactivated (4.5 m). ... groups. For coupling of antibodies for cell ... coupling with covalent binding of primary amine ... (SH)) occurringovernight. Coupling reactions can be performed ...
Biology Products: