Navigation Links
Lilly and Incyte Announce Baricitinib Efficacy and Safety Data from the Open-Label, Long-Term Extension of the Phase 2b JADA Study in Patients with Rheumatoid Arthritis
Date:6/13/2013

tal Sciences in the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences at the University of Oxford, and steering committee member for the study.

A copy of the EULAR oral presentation can be accessed at:  2013 EULAR - JADA 52-Week Presentation  

Trial DesignThis randomized, open-label, long-term extension of Phase 2b JADA study included 201 (95 percent) of the eligible 212 patients. Of the 201 patients, 184 completed 52 weeks of treatment, 15 discontinued treatment, and two patients had not yet completed the full 52 weeks of treatment. Patients received either 4 mg or 8 mg once-daily doses of baricitinib beginning at week 24 through week 52.

In the initial 12-week treatment duration, patients received one of four doses of baricitinib (1 mg, 2 mg, 4 mg or 8 mg) or placebo, administered once daily. In the 12- to 24-week portion of the study, patients initially randomized to placebo or the 1 mg baricitinib dose were re-randomized to receive either 4 mg once daily or 2 mg twice daily for an additional 12 weeks; patients initially randomized to the 2 mg, 4 mg and 8 mg doses continued therapy with those doses.

Patients who completed week 24 were eligible to receive either the 4- or 8-mg once daily dose through week 52. The study is ongoing, with all patients who are continuing in the study receiving baricitinib 4 mg once daily.

About JAK InhibitionThere are four known JAK enzymes: JAK1, JAK2, JAK3 and TYK2.[3] These enzymes are critical components of signaling mechanisms used by a number of cytokines and growth factors, including several that are elevated in patients with RA. Cytokines such as interleukin-6, -12 and -23 and both type 1 and type 2 interferons signal through these pathways. JAK-dependent cytokines have been implicated in the pathogenesis of a number of inflammatory and autoi
'/>"/>

SOURCE Eli Lilly and Company; Incyte Corporation
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related biology technology :

1. Lilly to Present at Goldman Sachs Global Healthcare Conference
2. Lilly Acquires Novel Tau Tangle Diagnostic Program to Bolster Alzheimers Disease Research and Development
3. Lilly and Incyte Announce Additional Phase IIb Baricitinib Data, Including MRI Results, in Patients with Rheumatoid Arthritis
4. SHAREHOLDER ALERT: The Law Firm of Levi & Korsinsky Notifies Investors with Losses on Their Investment in Incyte Corporation of Class Action Lawsuit and the May 6, 2013 Lead Plaintiff Deadline
5. Todays Research on Incyte and Arena Pharma: Biotech Stocks Up on Drug Approvals
6. Steep Hill Laboratories and Halent Scientific Proudly Announce Historic Merger
7. Andain Inc. Announces 2,000 Units Initial Production of the Breakthrough Miniature Disposable Insulin Pump for Use in Clinical Trials for Type-I and Type-II Diabetes
8. Verenium Announces Appointment Of Brian Carter As Vice President Of Grain Processing
9. Neogen announces Bohannon retirement, successor named
10. BioDelivery Sciences Announces NDA Submission for BUNAVAIL on Track Following Positive Pre-NDA Meeting with FDA
11. Hemostemix Announces Formation of Scientific Advisory Board
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)... (PRWEB) July 29, 2014 July ... vaccine pioneer in the biotechnology industry, announced that ... Coast Securities, Inc. to explore financing opportunities that ... technology, a breakthrough vaccine platform with the potential ... The company exclusively licensed the well-established LAMP platform ...
(Date:7/29/2014)... 2014 Quorum Review IRB, the ... awarded accreditation by the International Association of ... Six Sigma Deployment Program. The citation recognizes robust ... , Quorum’s Lean Six Sigma program was evaluated ... designation. The designation is a public statement of ...
(Date:7/29/2014)... MA (PRWEB) July 29, 2014 The ... Library of Congress was recently awarded to Juliana Hillis ... Stoneham, MA, for their project, “From an Egg, Everything: ... among 3,000 final entries for the National History Day ... than 300 historians and educators in Washington, D.C. , ...
(Date:7/28/2014)... light, developed by researchers at the University of Cambridge, ... the realm of science fiction, such as invisibility cloaks ... be a reality for quite some time, the technique ... blocks a few billionths of a metre across can ... through them, and works on large chunks all at ...
Breaking Biology Technology:Immunomic Therapeutics Engages Newport Coast Securities, Inc. 2Immunomic Therapeutics Engages Newport Coast Securities, Inc. 3Quorum Review IRB Accredited by IASSC for Lean Six Sigma Deployment Program 2Quorum Review IRB Accredited by IASSC for Lean Six Sigma Deployment Program 3In Vitro Fertilization (IVF) was the Subject of This Year’s Winning Entry for the Prestigious Library of Congress “Discovery or Exploration in History Award” 2In Vitro Fertilization (IVF) was the Subject of This Year’s Winning Entry for the Prestigious Library of Congress “Discovery or Exploration in History Award” 3Building 'invisible' materials with light 2
... are in U.S. dollars, QUEBEC CITY, Aug. 12 /PRNewswire-FirstCall/ ... global biopharmaceutical company focused on,endocrinology and oncology, today reported financial ... Second Quarter 2008 Highlights, - Advancement of ... - First efficacy trial: patient enrollment completed; ...
... agent and best biotechnology product,to be recognized at Sept. ... The Prix Galien USA 2008,( http://www.prix-galien-usa.com ) will recognize ... impact on the,quality of human life in ways that ... and chronic pain. Charlie Rose will,again emcee the awards ...
... (Nasdaq: VIAP ), a biotechnology company focused on ... announced today that,James G. Stewart, senior vice president and ... at the Fourth Annual Noble Financial Equity,Conference at 8:00 ... Loews Lake,Las Vegas Resort in Nevada., Interested parties ...
Cached Biology Technology:AEterna Zentaris Reports Second Quarter 2008 Financial and Operating Results 2AEterna Zentaris Reports Second Quarter 2008 Financial and Operating Results 3AEterna Zentaris Reports Second Quarter 2008 Financial and Operating Results 4AEterna Zentaris Reports Second Quarter 2008 Financial and Operating Results 5AEterna Zentaris Reports Second Quarter 2008 Financial and Operating Results 6AEterna Zentaris Reports Second Quarter 2008 Financial and Operating Results 7Prix Galien USA Announces 2008 Final Candidates 2VIA Pharmaceuticals to Present at Fourth Annual Noble Financial Equity Conference 2
(Date:7/29/2014)... Washington, USA The advanced optical methods and applications ... driving a revolution in the neurosciences were the inspiration ... by SPIE, the international society for optics and photonics. ... the BRAIN Initiative in the United States, and a ... for and provide examples of the impact that optics ...
(Date:7/29/2014)... As the climate warms and sea ice retreats, the ... season of increasingly open water which is predicted to ... of this century. Storms thus have the potential to ... a new and unpredictable element to the region. , A ... waves in the middle of the Arctic Ocean, and ...
(Date:7/29/2014)... science, researchers sometimes need to get back to ... that to study the impacts of the bumphead ... ecosystems at two remote locations in the central ... and computer simulation, McCauley, an assistant professor in ... and his colleagues sought to understand whether the ...
Breaking Biology News(10 mins):SPIE launches Neurophotonics journal with special section on BRAIN Initiative 2SPIE launches Neurophotonics journal with special section on BRAIN Initiative 3Huge waves measured for first time in Arctic Ocean 2Huge waves measured for first time in Arctic Ocean 3Underwater elephants 2Underwater elephants 3
... nations are more likely to die than female infants, ... lifespans, reveals a new study by researchers from University ... paper, which will be published online in the Monday, ... Academy of Sciences, analyzes 15 countries spanning three continents ...
... in a recent ,competition, against nature when scientists succeeded ... reaction for which no naturally occurring enzyme has evolved. ... a variety of potential applications in medicine and industry. ... model for understanding the intricate works of nature. These ...
... Black carbon, a form of particulate air pollution most ... and diesel exhaust, has a warming effect in the ... according to scientists in an upcoming review article in ... at UC San Diego atmospheric scientist V. Ramanathan and ...
Cached Biology News:Baby boys are more likely to die than baby girls 2Birth of an enzyme 2Birth of an enzyme 3Black carbon pollution emerges as major player in global warming 2Black carbon pollution emerges as major player in global warming 3
dithiothreitol (DTT) Reactive Dyes and Chemicals Thiol-Reactive Dyes, Haptens and Quenchers Reducing Agents...
Recombinant Equine IL-4, CF...
VACUGENE PUMP 110V, 1 EA. Category: Nucleid Acid Detection Systems....
...
Biology Products: