Navigation Links
Lilly and Incyte Announce Baricitinib Efficacy and Safety Data from the Open-Label, Long-Term Extension of the Phase 2b JADA Study in Patients with Rheumatoid Arthritis
Date:6/13/2013

p> Disease
Improvement /
Activity Measure24-WeekResponders/Total
Patients (Percent
Responders)52-WeekResponders/Total
Patients (Percent
Responders)ACR20

149/201 (74%)

139/196 (71%)ACR50

83/201 (41%)

96/197 (49%)ACR70

43/201 (21%)

53/197 (27%)CDAI Remission

34/200 (17%)

40/195 (21%)SDAI Remission

30/195 (15%)

42/194 (22%)DAS28 ESR <2.6

35/200 (18%)

47/195 (24%)DAS28 ESR </= 3.2

55/200 (28%)

82/195 (42%)DAS28 CRP <2.6

59/195 (30%)

80/194 (41%)DAS28 CRP </= 3.2

93/195 (48%)

116/194 (60%)Boolean Remission

19/195 (10%)

32/194 (16%) Safety ResultsSafety signals observed during the open-label extension were consistent with previously reported results of baricitinib. Among patients who remained on the 4 mg dose, treatment-emergent adverse events (TEAEs) occurred in 57 (53 percent); serious adverse events (SAEs) in 11 (10 percent); infections in 34 (31 percent); and serious infections in four (4 percent). Among patients who received the 8 mg dose, TEAEs occurred in 59 (63 percent); SAEs in eight (9 percent); infections in 37 (40 percent); and serious infections in two (2 percent). No opportunistic infections or tuberculosis cases were observed. There was one death in the 8 mg group due to a suspected myocardial infarction.

"In this clinical trial baricitinib showed statistically and clinically significant improvements in the features of this condition, which were maintained throughout a year of treatment. To date, baricitinib has demonstrated an acceptable safety profile and side effects have generally been straightforward to manage. These encouraging findings support further investigation of this new drug in rheumatoid arthritis," said Peter Taylor, M.A., Ph.D., F.R.C.P., Norman Collisson Chair of Musculoskele
'/>"/>

SOURCE Eli Lilly and Company; Incyte Corporation
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related biology technology :

1. Lilly to Present at Goldman Sachs Global Healthcare Conference
2. Lilly Acquires Novel Tau Tangle Diagnostic Program to Bolster Alzheimers Disease Research and Development
3. Lilly and Incyte Announce Additional Phase IIb Baricitinib Data, Including MRI Results, in Patients with Rheumatoid Arthritis
4. SHAREHOLDER ALERT: The Law Firm of Levi & Korsinsky Notifies Investors with Losses on Their Investment in Incyte Corporation of Class Action Lawsuit and the May 6, 2013 Lead Plaintiff Deadline
5. Todays Research on Incyte and Arena Pharma: Biotech Stocks Up on Drug Approvals
6. Steep Hill Laboratories and Halent Scientific Proudly Announce Historic Merger
7. Andain Inc. Announces 2,000 Units Initial Production of the Breakthrough Miniature Disposable Insulin Pump for Use in Clinical Trials for Type-I and Type-II Diabetes
8. Verenium Announces Appointment Of Brian Carter As Vice President Of Grain Processing
9. Neogen announces Bohannon retirement, successor named
10. BioDelivery Sciences Announces NDA Submission for BUNAVAIL on Track Following Positive Pre-NDA Meeting with FDA
11. Hemostemix Announces Formation of Scientific Advisory Board
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/18/2014)... (PRWEB) October 18, 2014 The ... defines and segments the bio-based advanced phase change ... of revenue. , Browse through the TOC of ... report to get an idea of the in-depth ... the segmentation in the Asia-Pacific bio-based advanced phase ...
(Date:10/18/2014)... October 18, 2014 The Asia-Pacific hardware ... market in Asia-Pacific with analysis and forecast of revenue. ... is expected to reach $51,362.6 million by 2018, at ... Browse through the TOC of the Asia-Pacific hardware encryption ... analysis provided. This also provides a glimpse of the ...
(Date:10/18/2014)... The Biomass Power industry ... years to 2014. The industry's expansion has been propelled ... that encouraged the use of biomass power. Furthermore, the ... which require local utilities to generate electricity from renewable ... Increased campaigning for green technology also influenced industry performance ...
(Date:10/18/2014)... The “Global Diagnostic Electrocardiograph (ECG) Market by Product ... Research Center, Physician Office, Nursing Homes), by Lead ... provides a detailed overview of the major drivers, ... impacting the global diagnostic ECG market along with ... share analysis. , The global diagnostic ECG market ...
Breaking Biology Technology:The Asia-Pacific Bio-based Advanced Phase Change Materials Market is estimated to grow to $39.8 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific Bio-based Advanced Phase Change Materials Market is estimated to grow to $39.8 million by 2018 - New Report by MicroMarket Monitor 3The Asia-Pacific Bio-based Advanced Phase Change Materials Market is estimated to grow to $39.8 million by 2018 - New Report by MicroMarket Monitor 4The Asia-Pacific hardware encryption display market is expected to reach $51,362.6 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific hardware encryption display market is expected to reach $51,362.6 million by 2018 - New Report by MicroMarket Monitor 3Biomass Power in the US Industry Market Research Report from IBISWorld Has Been Updated 2Biomass Power in the US Industry Market Research Report from IBISWorld Has Been Updated 3The Electrocardiograph (ECG) Market Is Expected to Reach $5,435 Million By 2020 - New Research Report by MarketsandMarkets 2The Electrocardiograph (ECG) Market Is Expected to Reach $5,435 Million By 2020 - New Research Report by MarketsandMarkets 3The Electrocardiograph (ECG) Market Is Expected to Reach $5,435 Million By 2020 - New Research Report by MarketsandMarkets 4The Electrocardiograph (ECG) Market Is Expected to Reach $5,435 Million By 2020 - New Research Report by MarketsandMarkets 5
... IL I didnt realize the depth of the task in ... together a Midwest list of public and private biotech companies. Because ... Illinois, which is the center of the Midwest. , ,A year ... 300 biotech companies in the Midwest with about 10 percent of ...
... industry accolades, dont think for a moment that Silicon ... its laurels. , ,Three days before its Altix 3000 family ... by Linux Journal Magazine, SGI rolled out the latest version ... system. The same day, the Mountain View-based company, whose only ...
... When the subject of training is discussed with small ... beyond the discussion phase. Training should be the cornerstone ... Microsoft, Hewlett-Packard, IBM, Cisco Systems, Intel, etc., training takes ... technology moves so quickly your skill sets can become ...
Cached Biology Technology:ePrairie Uncovers 80 Biotech Companies in Illinois 2ePrairie Uncovers 80 Biotech Companies in Illinois 3ePrairie Uncovers 80 Biotech Companies in Illinois 4ePrairie Uncovers 80 Biotech Companies in Illinois 5ePrairie Uncovers 80 Biotech Companies in Illinois 6ePrairie Uncovers 80 Biotech Companies in Illinois 7ePrairie Uncovers 80 Biotech Companies in Illinois 8ePrairie Uncovers 80 Biotech Companies in Illinois 9ePrairie Uncovers 80 Biotech Companies in Illinois 10ePrairie Uncovers 80 Biotech Companies in Illinois 11ePrairie Uncovers 80 Biotech Companies in Illinois 12ePrairie Uncovers 80 Biotech Companies in Illinois 13ePrairie Uncovers 80 Biotech Companies in Illinois 14ePrairie Uncovers 80 Biotech Companies in Illinois 15ePrairie Uncovers 80 Biotech Companies in Illinois 16ePrairie Uncovers 80 Biotech Companies in Illinois 17SGI, Introduces Powerful High End Visualization Tools 2SGI, Introduces Powerful High End Visualization Tools 3The Big Differentiator, Training! 2
(Date:10/15/2014)... Rosenstiel Award for Distinguished Work in Biomedical Science by ... of genomic instability and its implications for the immune ... to win the Rosenstiel Award; the first, Rod McKinnon, ... the Charles A. Janeway Professor of Pediatrics and Professor ... at the Howard Hughes Medical Institute at Boston Children,s ...
(Date:10/14/2014)... of years since T. rex took its ... scientists is breathing life back into dinosaurs using high-powered ... research has important implications for how dinosaurs used their ... sense of smell and cool their brains. , ... student Jason Bourke, lead author of the new study ...
(Date:10/14/2014)... 2014 – High doses of fish oil supplements, rich in ... type of irregular heartbeat in which the heart can beat ... the AFFORD trial led by the Montreal Heart Institute were ... Cardiology on October 7th. , For the trial, 337 ... randomly assigned to 4 grams of fish oil a day ...
Breaking Biology News(10 mins):Brandeis awards 44th Rosenstiel Award to pioneering geneticist Fred Alt 2Dinosaur breathing study shows that noses enhanced smelling and cooled brain 2Dinosaur breathing study shows that noses enhanced smelling and cooled brain 3
... or cod caught in the North Sea but declared as ... of fraud in the fisheries sector. A European Commission report ... genomics, chemistry and forensics - can provide clear answers to ... from.where was this fish caught.is it wild or farmed?". The ...
... this study, conducted in Germany, re-open the debate on ... patients in the placebo-group are at a serious disadvantage ... analysed current study designs, for new therapies such as ... that patients in the placebo group experienced no change ...
... published in the current (May 27) edition of the journal ... that concluded that a bacterial bloom in the Gulf of ... The debate has implications for the Gulf of Mexico ... global warming, said marine scientist and lead author Samantha Joye, ...
Cached Biology News:What fish is on your plate? 2Science paper argues against conclusion that bacteria consumed Deepwater Horizon methane 2Science paper argues against conclusion that bacteria consumed Deepwater Horizon methane 3