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Lilly and Incyte Announce Additional Phase IIb Baricitinib Data, Including MRI Results, in Patients with Rheumatoid Arthritis
Date:11/13/2012

that JAK inhibitors may be useful for the treatment of a broad range of inflammatory conditions.

About Baricitinib
Baricitinib is an orally administered selective JAK1 and JAK2 inhibitor that spares JAK3. Baricitinib is advancing into Phase III development as a potential treatment for rheumatoid arthritis and it is in Phase II development as a potential treatment for psoriasis and diabetic nephropathy.

Four Phase III RA studies are planned, which will investigate the safety and efficacy of baricitinib 2 mg and 4 mg once daily in patients with active RA who are methotrexate-naive, biologic-naive or biologic-experienced. Patients completing any of the four studies will be eligible for enrollment in a fifth study, a long-term extension.

In December 2009, Lilly and Incyte announced an exclusive worldwide license and collaboration agreement for the development and commercialization of baricitinib and certain follow-on compounds for inflammatory and autoimmune diseases.

About Rheumatoid Arthritis
Rheumatoid arthritis is characterized by abnormal immune mechanisms that lead to joint inflammation and swelling with progressive destruction of joints. In addition to affecting the joints, RA also can affect connective tissue in the skin and organs of the body.[2]

Current treatment of RA includes the use of non-steroidal anti-inflammatory drugs, oral disease-modifying antirheumatic drugs such as methotrexate, and injectable biological response modifiers that target tumor necrosis factor, a pro-inflammatory cytokine implicated in the pathogenesis of RA.

About the Webcast
Lilly and Incyte are hosting an investor meeting to discuss the baricitinib Phase II RA data presented at ACR. The presentation will be webcast live at 7 p.m. ET on Nov. 13, 2012 and will be available as a replay on both Lilly's website at http://investor.lilly.com/events.cfm and Incyte's website at '/>"/>

SOURCE Eli Lilly and Company; Incyte Corporation
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