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Reconciliation of 2008 Earnings Per Share Expectations:
2008 2007
Expectations Results % Growth
--------------- --------- ---------
E.P.S. (reported) $3.73 to $3.90 $2.71
Eliminate estimated charge
related to asset impairments
and certain wind-down costs
associated with the
termination of the AIR Insulin
program .05 to .07
Eliminate estimated in-process
research and development
charge associated with BioMS
Medical in-licensing .05
Eliminate asset impairments,
restructuring and other
special charges - .15
Eliminate charge for a
reduction in expected
insurance recoveries - .06
Eliminate in-process research
& development charges
associated with ICOS, Hypnion, - .63
and Ivy acquisitions and OSI,
MacroGenics and Glenmark in-
licensing transactions
Include pro forma as if the
ICOS acquisition was completed
on January 1, 2006 - (.01)
-------------- ---------
E.P.S. (pro forma adjusted) $3.85 to $4.00 $3.54 9% to 13%
-------------- ---------
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portfolio of first-in-class and best-in-class pharmaceutical products by
applying the latest research from its own worldwide laboratories and from
collaborations with eminent scientific organizations. Headquartered in
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