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Lilly Acquires Novel Tau Tangle Diagnostic Program to Bolster Alzheimer's Disease Research and Development
Date:4/17/2013

evelopment of our anti-amyloid and anti-tau based therapies to treat this disease."

"PET imaging is a valuable tool in the fight against Alzheimer's disease, and Siemens is committed to helping fight this growing threat to our aging population," said James Williams , CEO, Siemens Molecular Imaging business unit. "Lilly's continued development of these tau PET tracers combined with Siemens' ongoing investment in innovative PET imaging solutions is another great example of how Siemens is collaborating with pharmaceutical companies in an effort to provide new hope to patients and their families." 

There are two defining pathologies linked to the development of Alzheimer's disease: the accumulation of amyloid-beta protein that forms beta-amyloid plaques outside of neurons, and the accumulation of tau protein that forms tau tangles inside them.The formation of tau tangles is thought to block the transport of nutrients and essential molecules throughout the cell, leading to neurodegeneration, or the progressive loss of structure or function of neurons. The formation of tau tangles mostly occurs after beta-amyloid plaques have developed, but unlike beta-amyloid plaques the evolution of tau tangle pathology is believed to closely mirror cognitive decline.

Scientists theorize that both beta-amyloid plaques and tau tangles are required for the development of Alzheimer's disease, with the accumulation of amyloid beta representing the early trigger that initiates the disease process and tau tangles playing a secondary but critical role in the process of neuronal toxicity and death. For this reason, Lilly has established R&D programs to explore both the amyloid and tau hypotheses. Today's acquisition will inform and help progress Lilly's multiple approaches to treating Alzheimer's disease
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SOURCE Eli Lilly and Company
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