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Life Technologies Launches Highly Efficient Stem Cell Reprogramming Technology
Date:6/15/2011

CARLSBAD, Calif., June 15, 2011 /PRNewswire/ -- Life Technologies Corporation today announced the launch of CytoTune™-iPS Reprogramming Kit -- research technology that provides far improved efficiency over standard methods to develop induced pluripotent stem cells (iPSCs) from human somatic cells. The ability to more easily create larger numbers of these embryonic stem cell-like cells can expedite basic research and studies that target specific diseases.

Widely accepted methods for turning adult skin cells, for example, into iPSCs involve benign virus vectors that are used to deliver reprogramming genes.  The process, however, is woefully inefficient (reprogramming efficiency rates for standard methods range between 0.00001-0.01 percent) and runs the risk of leading to unwanted mutations since the vectors must insert themselves into the host cell's DNA – essentially altering the genome and leaving "footprints."

The CytoTune™-iPS Reprogramming Kit is based on zero-footprint technology that employs an RNA virus developed by the Japanese firm DNAVEC Corporation.  The benign vectors effectively do their job without DNA integration and can generate iPSCs with about 1 percent efficiency.

"This technology is the most successful method my lab has used to generate iPSCs," said Keiichi Fukuda, Ph.D., M.D. Professor and Chief, Department of Cardiology, and Vice Dean at the Keio University School of Medicine, whose research team demonstrated the effectiveness of CytoTune's RNA vector in a study published in the journal Cell Stem Cell.  "Considering the high efficiency of iPSC generation and absence of integration of the vectors into the host genome, this method is definitely the most powerful tool av
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SOURCE Life Technologies Corporation
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