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Lexicon to Present at Two Major Healthcare Investor Conferences
Date:6/3/2010

and diagnostics sectors.  The Jefferies Global Life Sciences Conference will feature presentations from more than 350 public and private healthcare companies across the life sciences spectrum, including biotechnology, life science tools, medical devices, diagnostics, specialty pharmaceutical, and multi-national pharma.

About Lexicon

Lexicon is a biopharmaceutical company focused on discovering and developing breakthrough treatments for human disease.  Lexicon currently has four drug candidates in mid-stage development for diabetes, irritable bowel syndrome, carcinoid syndrome and rheumatoid arthritis, all of which were discovered by Lexicon's research team.  Lexicon has used its proprietary gene knockout technology to identify more than 100 promising drug targets.  Lexicon has focused drug discovery efforts on these biologically-validated targets to create its extensive pipeline of clinical and preclinical programs.  For additional information about Lexicon and its programs, please visit www.lexpharma.com.

Safe Harbor Statement

This press release contains "forward-looking" statements, including statements relating to Lexicon's growth and future operating results, discovery and development of products, strategic alliances and intellectual property, as well as other matters that are not historical facts or information.  All forward-looking statements are based on management's current assumptions and expectations and involve risks, uncertainties and other important factors, specifically including those relating to Lexicon's ability to successfully conduct preclinical and clinical deve
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SOURCE Lexicon Pharmaceuticals, Inc.
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3. Lexicon Announces Proposed Offering of 27,500,000 Shares of Common Stock
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5. Lexicon to Provide Clinical Pipeline Update and Report Second Quarter 2009 Financial Results on July 28, 2009
6. Lexicon Initiates Phase 2 Clinical Trial of LX1032 in Patients With Carcinoid Syndrome
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8. Lexicon to Present Clinical Data for LX1031 and LX1032 at Digestive Disease Week
9. Lexicon to Provide Clinical Pipeline Update and Report First Quarter 2009 Financial Results on April 28, 2009
10. Lexicon Pharmaceuticals 2008 Annual Report to Stockholders Available Online
11. Nuevolution Announces Drug Discovery Alliance With Lexicon Pharmaceuticals
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