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Lexicon Presents Class of Compounds Modulating TPH1, the Target for its LX1031 Investigational Drug for Irritable Bowel Syndrome
Date:8/21/2007

dings have allowed us to pursue a potential new mechanism for treating conditions, such as IBS, that are not well-served by current therapies."

Using Lexicon's proprietary knock-out mouse technology, company scientists established that serotonin in the brain and neurons is synthesized by TPH2, an enzyme related to but distinct from TPH1, which is responsible for the synthesis of almost all peripheral serotonin. Knock-out studies showed that mice lacking a functional TPH1 gene exhibited normal brain levels of serotonin with no detectable levels in the periphery. Importantly, the TPH1 knockout mice were healthy and exhibited no significant adverse effects.

Top-line Phase 1 clinical results for LX1031 are expected to be presented at the American College of Gastroenterology's Annual Scientific Meeting in Philadelphia in October.

About Lexicon

Lexicon is a biopharmaceutical company focused on the discovery and development of breakthrough treatments for human disease. Lexicon currently has development programs underway for such areas of major unmet medical need as irritable bowel syndrome and cognitive disorders. The company has used its proprietary gene knockout technology to discover more than 100 promising drug targets and create an extensive pipeline of clinical and preclinical programs in the therapeutic areas of diabetes and obesity, cardiovascular disease, psychiatric and neurological disorders, cancer, immune system disorders and ophthalmic disease. To advance the development and commercialization of its programs, Lexicon is working both independently and through collaborators including Bristol-Myers Squibb Company, Genentech, Inc. and N.V. Organon. For additional information about Lexicon and its programs, please visit http://www.lexpharma.com.

Safe Harbor Statement

This press release contains "forward-looking statements," including statements relating to Lexicon's clinical d
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SOURCE Lexicon Pharmaceuticals, Inc.
Copyright©2007 PR Newswire.
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