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Lexicon Pharmaceuticals Provides Clinical Pipeline Update and Reports 2010 Third Quarter Financial Results
Date:11/5/2010

THE WOODLANDS, Texas, Nov. 5, 2010 /PRNewswire-FirstCall/ -- Lexicon Pharmaceuticals, Inc. (Nasdaq: LXRX), a biopharmaceutical company focused on discovering breakthrough treatments for human disease, today updated the progress of its drug development programs and reported financial results for the three and nine months ended September 30, 2010.  

"Having established proof-of-concept for two new mechanisms of action in irritable bowel syndrome and diabetes, we are now preparing our drug candidates for the next phase of development, with a focus on formulation and dose selection in order to optimize the ultimate commercial product opportunity for these programs," said Dr. Arthur T. Sands, president and chief executive officer of Lexicon.  "Over the coming months, we are also looking forward to two more proof-of-concept results in rheumatoid arthritis and carcinoid syndrome."

Key Progress in Clinical Pipeline

  • Diabetes:  Lexicon continues to progress its dual sodium-glucose cotransporter 1 (SGLT1) and SGLT2 inhibitor, LX4211, in patients with type 2 diabetes.  In preparation for a 12-week Phase 2b study that is anticipated to initiate around mid-year 2011, a 13-week toxicology study was completed, a prototype tablet has been formulated, and a pharmacokinetic/pharmacodynamic study in humans has been initiated to evaluate the bioequivalence of the solid oral formulation compared to the liquid formulation that was used in the previous studies and to further evaluate various measures of glucose control and GLP-1 signaling.
  • Irritable Bowel Syndrome:  Reformulation
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  • SOURCE Lexicon Pharmaceuticals, Inc.
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