Navigation Links
Lexicon Files Investigational New Drug Application for LX1032 as a Potential Treatment for Carcinoid Syndrome
Date:12/21/2007

THE WOODLANDS, Texas, Dec. 21 /PRNewswire-FirstCall/ -- Lexicon Pharmaceuticals, Inc. (Nasdaq: LXRX) announced today that it has submitted an investigational new drug (IND) application to the U.S. Food and Drug Administration (FDA) for LX1032, an oral drug candidate for managing gastrointestinal symptoms associated with carcinoid syndrome. The initial Phase 1 clinical trial of LX1032 is planned as a double-blind, randomized, placebo-controlled, ascending single-dose study in healthy volunteers. This study is designed to evaluate the safety, tolerability, and pharmacokinetics of LX1032. Lexicon expects to initiate clinical trials with LX1032 following FDA review.

"We believe LX1032 has the potential to be an important new therapy in an area of high unmet medical need," said Philip M. Brown, M.D., J.D., vice president of clinical development at Lexicon. "LX1032 may offer important benefits to patients with carcinoid syndrome, who have very limited treatment options."

Carcinoid syndrome is the result of metastatic carcinoid tumors that usually originate from enterochromaffin cells in the lining of the gastrointestinal tract. These tumors secrete large amounts of serotonin, which causes a variety of symptoms that often includes severe diarrhea and abdominal discomfort. Carcinoid tumors are a type of neuroendocrine tumor and, according to the American Cancer Society, about 11,000 to 12,000 neuroendocrine tumors and neuroendocrine cancers are diagnosed each year in the United States. About 10% of people with carcinoid tumors will develop carcinoid syndrome.

The target for LX1032 was identified through the Genome5000(TM) project, Lexicon's program to identify the function of 5,000 druggable genes in the human genome. LX1032
'/>"/>

SOURCE Lexicon Pharmaceuticals, Inc.
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3

Related biology technology :

1. Lexicon Presents Class of Compounds Modulating TPH1, the Target for its LX1031 Investigational Drug for Irritable Bowel Syndrome
2. Lexicon Pharmaceuticals to Present at the UBS Global Life Sciences Conference
3. Lexicon Appoints Judith Swain, M.D. to Board of Directors
4. Lexicon Pharmaceuticals to Present at ThinkEquity ThinkClinic
5. Lexicon Pharmaceuticals to Present at Bio InvestorForum
6. Lexicon to Report Third Quarter 2007 Financial Results on October 30, 2007
7. Lexicon Pharmaceuticals Reports 2007 Third Quarter Financial Results
8. Lexicon Pharmaceuticals to Present at the Piper Jaffray 19th Annual Health Care Conference
9. Lexicon Pharmaceuticals to Present at RBC Capital Markets Healthcare Conference
10. China Kangtai Cactus Biotech Files 2nd Quarter 2007 10QSB and Announces Unaudited Quarterly Results
11. ImmuneRegen BioSciences Files 8-K that Highlights Enclosed Shareholder Letter Discussing Recent Achievements and Outlook
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... RICHLAND, Wash. The lithium-ion batteries that power our ... run longer on a single charge with the help ... the porous material to replace the graphite traditionally used ... more than 10 times the energy storage capacity of ... lithium-ion battery electrode was published today in Nature ...
(Date:7/10/2014)... Since the 1960s, theatergoers have shelled out for ... to enhance their viewing experience. These basic devices, ... artificial three-dimensional reality, may soon be rendered obsolete ... by Tel Aviv University researchers. , TAU doctoral ... have developed highly efficient holography based on nanoantennas ...
(Date:7/10/2014)... universities and NPL collaborate to bring together their track ... complementary academic strengths., Working with BIS and NPL the ... of the UK. The establishment of a Graduate Institute, ... will provide a pipeline of skilled researchers. Working with ... will be grown through the creation of a series ...
(Date:1/15/2014)... Nobel laureate Herbert Kroemer famously observed, referring to ... junctures where layers of different materials meet. In ... layers of metal oxides are becoming increasingly prominent, ... high-temperature superconductors, ferroelectrics and multiferroics. Realizing the vast ...
Breaking Biology Technology:Silicon sponge improves lithium-ion battery performance 2Silicon sponge improves lithium-ion battery performance 3Projecting a 3-dimensional future 2Projecting a 3-dimensional future 3Universities of Surrey and Strathclyde selected as strategic partners in the future operation of the National Physical Laboratory 2Universities of Surrey and Strathclyde selected as strategic partners in the future operation of the National Physical Laboratory 3A deeper look at interfaces 2
... , , , , Vincent ... Westbury, New York , , , ... Perhaps the most critical parameter for successful , PCR is ... primer can result in a PCR reaction that will not work. The primer sequence , ...
... , , , , Karen Sermon, M.D., PhD ... Hospital and Medical School of the Dutch-speaking Brussels Free , University, , ... , , , , ... Preimplantation diagnosis (PGD) is a very early form of prenatal diagnosis: , ...
... Ends , Using the Eppendorf Mastercycler gradient , ... Ulrich Genschel , Institute of General Botany, University ... , , , , ... In many research projects, cDNA isolation forms the basis for detailed , ...
Cached Biology Technology:General Notes on Primer Design in PCR* 2General Notes on Primer Design in PCR* 3General Notes on Primer Design in PCR* 4General Notes on Primer Design in PCR* 5General Notes on Primer Design in PCR* 6The use of the Mastercycler gradient for single-cell PCR and preimplantation , diagnosis 2The use of the Mastercycler gradient for single-cell PCR and preimplantation , diagnosis 3The use of the Mastercycler gradient for single-cell PCR and preimplantation , diagnosis 4The use of the Mastercycler gradient for single-cell PCR and preimplantation , diagnosis 5Optimizing the Direct Amplification of Missing cDNA 5' Ends, Using the Eppendorf Mastercycler gradient 2Optimizing the Direct Amplification of Missing cDNA 5' Ends, Using the Eppendorf Mastercycler gradient 3Optimizing the Direct Amplification of Missing cDNA 5' Ends, Using the Eppendorf Mastercycler gradient 4Optimizing the Direct Amplification of Missing cDNA 5' Ends, Using the Eppendorf Mastercycler gradient 5
(Date:7/10/2014)... 2014 Research and Markets ( http://www.researchandmarkets.com/research/h7h8lq/gesture ... "Global Gesture Recognition & Touch-Less Sensing (2D, 3D, ... report to their offering ... & Touch-Less Sensing Market to Grow Exponentially. Touch-less ... but the companies were unable to leverage this ...
(Date:7/10/2014)... July 8, 2014 Fingerprint ... new design win (DW). An Asian OEM has selected FPC1021 ... production start in August 2014.   FPC is ... which has a planned date for start of mass production ... order of SEK 5M, for delivery in the first half ...
(Date:7/10/2014)... large, mainly tropical flowering plant family Melastomataceae (Meadow Beauty Family). ... on bees for their pollination. Only about 100 are known ... of Axinaea appear in clusters of few to ... species are pink, yellow, orange or red. The stamens (male ... their bulbous appendages. The pollination mechanism of Axinaea ...
Breaking Biology News(10 mins):Global Gesture Recognition & Touch-Less Sensing (2D, 3D, Ultrasonic, IR, Capacitive) Market - Forecasts to 2020 2FPC Wins DW and Initial Ramp Order for FPC1021 Touch Sensor for Flagship Smartphone from Asian OEM 2Novel type of bird pollination mechanism discovered in South America 2
... at Texas A&M University College of Veterinary Medicine & Biomedical ... of a foal using oocytes from a live mare, the ... foal highlights Texas A&M,s long tradition of leading science in ... owner of the new foal., "I,ve always liked having three ...
... This release is available in German ... of young researchers in Germany, the Deutsche Forschungsgemeinschaft (DFG, ... Groups. This decision was made by the DFG,s relevant ... will enable doctoral researchers to complete their training at ...
... The mechanism by which ,polycomb, proteins critical for embyronic stem ... identified by UCL scientists. The discovery, which has ... is detailed in research published today in the journal ... stem cells is the suppression of genes that when later ...
Cached Biology News:Texas A&M veterinary researchers achieve cloning first 2Texas A&M veterinary researchers achieve cloning first 3DFG establishes 12 new research training groups 2DFG establishes 12 new research training groups 3DFG establishes 12 new research training groups 4DFG establishes 12 new research training groups 5DFG establishes 12 new research training groups 6How the wrong genes are repressed: New finding from UCL 2
jub, ajuba homolog (Xenopus laevis)...
Prepared in distilled water....
in vitro Translation, Accessory Products...
... The Zero Blunt TOPO ... Sequencing is designed for ... of blunt-end PCR products. ... 5-minute TOPO Cloning and ...
Biology Products: