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Lexicon Appoints Judith Swain, M.D. to Board of Directors
Date:9/25/2007

New Composition of Board Reflects Emphasis on Drug Development and Recent

Private Equity Investment

THE WOODLANDS, Texas, Sept. 25 /PRNewswire-FirstCall/ -- Lexicon Pharmaceuticals, Inc. (Nasdaq: LXRX) announced several changes to the composition of its board of directors reflecting its continuing advancement into drug development and the completion of a major strategic financing with Invus, LP. With extensive experience in clinical medicine and biological science, Judith L. Swain, M.D. has been appointed to the Lexicon board of directors, and will play a key role in advising the company on the progression of its drug candidate pipeline through preclinical and clinical development. Coinciding with Dr. Swain's appointment, Dr. Clayton Rose and Dr. Barry Mills, who helped lead the board's efforts in overseeing the successful negotiation and completion of the Invus transaction, have resigned their positions on Lexicon's board of directors effective September 30, 2007. As a result of that financing, Lexicon appointed Raymond Debbane, Philippe J. Amouyal and Christopher J. Sobecki to the board. Taken together, the recent appointments and resignations bring Lexicon's board of directors to a current total of ten members.

"We are indeed privileged to have one of medicine's leading physician scientists join Lexicon's board of directors. A recognized expert in cardiovascular disease, Dr. Swain also brings a broad understanding of clinical medicine with in-depth knowledge of the challenges of clinical research. As part of her extensive medical leadership experience, Dr. Swain possesses an international perspective on emerging medical opportunities in Asia, and a unique understanding of the hu
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SOURCE Lexicon Pharmaceuticals, Inc.
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