Navigation Links
Lentigen Corporation Announces Exclusive Licensing Agreement With Case Western Reserve University to Develop Novel Stem-Cell Therapy for Brain Cancer
Date:3/20/2008

GAITHERSBURG, Md., March 20 /PRNewswire/ -- Lentigen Corporation today announced an exclusive licensing agreement with Case Western Reserve University (CWRU) in Cleveland, Ohio, to develop a novel stem-cell therapy for glioblastoma, an aggressive type of brain cancer. Under the agreement, Case Western and its primary affiliate, University Hospitals Case Medical Center, will lead the first in vivo clinical trial, and Lentigen will be responsible for further clinical development and commercialization.

The new therapy will be based on MGMT, a gene that has been shown to repair damaged DNA. A specially designed lentiviral vector will be used to deliver the gene specifically to bone-marrow stem cells that have been damaged by drugs commonly used to treat cancer. A Phase I clinical trial, which will be held at Case Western later this year, will evaluate the potential of this lentiviral vector-MGMT technology (LV-MGMT) to enhance current treatments for glioblastoma by repairing and preventing this damage to bone-marrow stem cells.

"This clinical trial will represent the first time lentiviral vectors will be used with MGMT for stem cell therapy in humans," said Stanton L. Gerson, MD, director of the Ireland Cancer Center of University Hospitals Case Medical Center and the Case Comprehensive Cancer Center, who co-developed the technology with Anthony E. Pegg, Ph.D., the Evan Pugh Professor of Cellular and Molecular Physiology, and Pharmacology at Penn State University. Dr. Gerson commented, "Glioblastoma is a serious diagnosis with limited treatment options, so this new therapeutic approach has the potential to greatly enhance options for patients with this terrible disease."

Boro Dropulic, Ph.D., Lentigen's founder, president and chief scientific officer, commented, "LV-MGMT technology has the potential to greatly enhance the therapeutic efficacy of existing drugs that target glioblastoma by lowering their toxicity to bone marrow stem cells. Beyond glioblastoma, this technology could also be used for therapies for other diseases such as AIDS, leukemia and hemophilia. We are quite excited to be working with Dr. Gerson to move LV-MGMT into the clinic."

Tim Ravenscroft, Lentigen's CEO, commented, "We feel very fortunate to be collaborating with Dr. Gerson to develop this promising technology with broad potential applications. Our exclusive license to develop this technology is a significant step towards our goal of applying our lentiviral vector expertise to the development of cutting-edge biotherapeutics."

About Lentiviral Vectors

Lentiviral vectors (LV) are vehicles that can deliver genes or RNAi into cells with up to 100% efficiency and stability. By comparison, other viral vector systems such as non-viral, adenoviral and adeno-associated viral vectors have not been shown to achieve both high and stable gene delivery in dividing cells.

Gene delivery is accomplished by the binding and fusing of the LV pseudotyped envelope protein to the target cell membrane. The LV RNA containing the gene or gene silencing sequence is then incorporated into the cell via reverse transcription creating a DNA complex. This complex enters the nucleus incorporating into the chromosomal DNA creating a stable molecule. The gene sequence is integrated in the chromosome and is copied along with the DNA during ongoing cell division.

About Lentigen Corporation

Lentigen Corporation is a privately owned biotechnology company focused on the development of lentiviral vector technology for a wide range of therapeutic, vaccine and research applications in biotechnology and medicine. Lentiviral vectors are the most efficient vehicles for the delivery of genes or gene silencing sequences stably into cells. Lentigen is a highly collaborative company, co-developing lentiviral vector-based products across a broad spectrum of bench to clinical applications. Partnerships include The National Institutes of Health, The University of Pennsylvania, ThermoFisher Scientific and The U.S. Army. For further information, visit http://www.lentigen.com. http://www.lentigen.com/

Contact:

Gregory Tiberend

gtiberend@rlcinc.com

Meghan Feeks

mfeeks@rlcinc.com

Richard Lewis Communications, Inc.

212-827-0020


'/>"/>
SOURCE Lentigen Corporation
Copyright©2008 PR Newswire.
All rights reserved

Related biology technology :

1. VIRxSYS and Lentigen Announce Litigation Settlement
2. Lentigen Appoints Tim Ravenscroft as Chief Executive Officer
3. Lentigen to Move Headquarters and Manufacturing to Gaithersburg
4. Memry Corporation Announces Preliminary Fiscal Fourth Quarter and 2007 Revenue
5. PeriCor Therapeutics Announces Closing of Licensing Agreement for Acadesine with Schering-Plough Corporation
6. AGA Medical Corporation Receives FDA and CE Mark Approvals for the AMPLATZER Vascular Plug II
7. Drug Royalty Corporation (DRC) Announces Acquisition Regarding PEG-INTRON(R) From Enzon Pharmaceuticals, Inc. (ENZN)
8. BioElectronics Corporation Announces Singapore and Malaysia Sales
9. Avicena Signs Worldwide Exclusive Distribution Agreement with RITA Corporation for its Proprietary Dermaceutical Compounds
10. DURECT Corporation to Present at the NewsMakers in the Biotech Industry Investment Conference
11. Insulet Corporation to Present at the Thomas Weisel Partners Healthcare Conference on September 6, 2007
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... , June 27, 2016   Ginkgo Bioworks , ... industrial engineering, was today awarded as one of ... of the world,s most innovative companies. Ginkgo Bioworks ... for the real world in the nutrition, health ... work directly with customers including Fortune 500 companies ...
(Date:6/24/2016)... Epic Sciences unveiled a liquid biopsy ... PARP inhibitors by targeting homologous recombination deficiency (HRD) ... test has already been incorporated into numerous clinical ... Over 230 clinical trials are investigating ... PARP, ATM, ATR, DNA-PK and WEE-1. Drugs targeting ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Researchers at the ... commonly-identified miRNAs in people with peritoneal or pleural mesothelioma. Their findings are the subject ... it now. , Diagnostic biomarkers are signposts in the blood, lung fluid or ...
(Date:6/23/2016)... Wausau, WI (PRWEB) , ... June 23, 2016 ... ... probiotic supplements, is pleased to announce the launch of their brand, UP4™ Probiotics, ... supplements for over 35 years, is proud to add Target to its list ...
Breaking Biology Technology:
(Date:6/15/2016)... , June 15, 2016 ... report titled "Gesture Recognition Market by Application Market - Global Industry ... - 2024". According to the report, the  global gesture ... in 2015 and is estimated to grow at ... billion by 2024.  Increasing application of ...
(Date:6/2/2016)... 2, 2016 The Department of Transport ... the 44 million US Dollar project, for the , ... including Personalization, Enrolment, and IT Infrastructure , to ... production and implementation of Identity Management Solutions. Numerous renowned international ... Decatur was selected for the most compliant ...
(Date:5/20/2016)...  VoiceIt is excited to announce its new ... By working together, VoiceIt and VoicePass will offer ... take slightly different approaches to voice biometrics, collaboration ... usability. Both ... "This marketing and technology partnership allows ...
Breaking Biology News(10 mins):