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Lentigen Corporation Announces Exclusive Licensing Agreement With Case Western Reserve University to Develop Novel Stem-Cell Therapy for Brain Cancer
Date:3/20/2008

GAITHERSBURG, Md., March 20 /PRNewswire/ -- Lentigen Corporation today announced an exclusive licensing agreement with Case Western Reserve University (CWRU) in Cleveland, Ohio, to develop a novel stem-cell therapy for glioblastoma, an aggressive type of brain cancer. Under the agreement, Case Western and its primary affiliate, University Hospitals Case Medical Center, will lead the first in vivo clinical trial, and Lentigen will be responsible for further clinical development and commercialization.

The new therapy will be based on MGMT, a gene that has been shown to repair damaged DNA. A specially designed lentiviral vector will be used to deliver the gene specifically to bone-marrow stem cells that have been damaged by drugs commonly used to treat cancer. A Phase I clinical trial, which will be held at Case Western later this year, will evaluate the potential of this lentiviral vector-MGMT technology (LV-MGMT) to enhance current treatments for glioblastoma by repairing and preventing this damage to bone-marrow stem cells.

"This clinical trial will represent the first time lentiviral vectors will be used with MGMT for stem cell therapy in humans," said Stanton L. Gerson, MD, director of the Ireland Cancer Center of University Hospitals Case Medical Center and the Case Comprehensive Cancer Center, who co-developed the technology with Anthony E. Pegg, Ph.D., the Evan Pugh Professor of Cellular and Molecular Physiology, and Pharmacology at Penn State University. Dr. Gerson commented, "Glioblastoma is a serious diagnosis with limited treatment options, so this new therapeutic approach has the potential to greatly enhance options for patients with this terrible disease."

Boro Dropulic, Ph.D., Lentigen's founder, president and chief scientific officer, commented, "LV-MGMT technology has the potential to greatly enhance the therapeutic efficacy of existing drugs that target glioblastoma by lowering their toxicity to bone marrow stem cells. Beyo
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SOURCE Lentigen Corporation
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