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Leading Heart Specialist Joins Duska Therapeutics as Scientific Consultant
Date:10/23/2008

lly appreciated until recently, researchers now know that one of the major ways in which nitric oxide influences heart function is by activating the main calcium channel in the heart to release calcium from intracellular stores. Calcium is the primary determinant of contractility in the heart. A deficiency in nitric oxide disrupts the calcium cycle, inhibits heart contractility, and ultimately causes the heart to fail.

In addition to helping to elucidate a biologic basis of heart failure, Dr. Stamler has developed and tested new therapeutic modalities to preserve and improve cardiac function. He is one of the inventors of the patents underlying the drug portfolio that includes CDP-1050, which Duska recently licensed from Duke University and Johns Hopkins University.

CDP-1050 is an investigational drug candidate for the treatment of heart failure. The drug is designed to correct nitric oxide and redox imbalance in the failing heart and the cardiovascular system. CDP-1050 has a dual mechanism of action to inhibit the creation of excessive reactive oxygen radicals and restore nitric oxide to physiologic levels. The principal therapeutic target is the ryanodine receptor, the main ion channel in the heart that supplies the calcium necessary for the heart to contract. CDP-1050 is expected to enter a Phase 2 clinical study early next year.

"With its strong scientific underpinnings and commercial orientation, the Duska team is the perfect group to organize and manage the CDP-1050 Phase 2 proof-of-concept study in heart failure patients," Dr. Stamler commented. "CDP-1050 is pioneering a new paradigm of heart failure treatments by directly repairing molecular damage to the heart, the root cause of heart failure."

"Dr. Stamler has developed proprietary investigational drugs for heart failure based on his comprehensive and profound understanding of the signal transduction defects underlying the disease. We believe that his formal involvement with Dus
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SOURCE Duska Therapeutics, Inc.
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