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Leading Heart Specialist Joins Duska Therapeutics as Scientific Consultant
Date:10/23/2008

Dr. Jonathan Stamler Has Authored A New Understanding Of Heart Failure

LA JOLLA, Calif., Oct. 23 /PRNewswire-FirstCall/ -- Duska Therapeutics, Inc. (OTC Bulletin Board: DSKA) ("Duska") announced today that Jonathan S. Stamler, M.D., has joined the company as an exclusive scientific consultant to advise on the clinical development of CDP-1050, a drug candidate for the treatment of heart failure.

Dr. Stamler is the George Barth Geller Professor of Research in Cardiovascular Diseases and Professor of Medicine and Biochemistry at Duke University. He has conducted scientific studies that establish a ubiquitous role for nitric oxide in the regulation of protein function. Dr. Stamler's research supports the hypothesis that dysregulated nitric oxide signaling commonly contributes to human disease including heart failure, arrhythmia, respiratory diseases, and cancer.

Dr. Stamler's notable achievements include the discovery that nitric oxide is transported by hemoglobin in red blood cells and has a pivotal role in control of blood flow; the mechanism by which nitroglycerin alleviates chest pain in angina patients and the cause of nitrate tolerance in these same patients; and the finding that depletion of nitric oxide from stored red blood cells may be the underlying cause for the undesired outcomes arising from blood transfusions such as higher incidence of heart attack, heart failure, stroke and even death. He has also discovered a general mechanism by which protein function is regulated (termed S-nitrosylation), malfunction of which contributes to many human diseases.

Dr. Stamler has conducted research on nitric oxide-redox imbalance in the failing heart and cardiovascular system. This research has yielded key evidence that altered production and distribution of reactive oxygen and nitric oxide species damages the cardiovascular system and contributes to the poor pumping capacity that characterizes the failing heart.

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SOURCE Duska Therapeutics, Inc.
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