Navigation Links
Latest Cell Publication of OriGene and Peking University Collaborative Discovery of New iPSC Reprogramming Factors
Date:6/3/2013

Rockville, MD (PRWEB) June 03, 2013

Scientists from Peking University, China and OriGene Technologies jointly published that multiple lineage specifier genes can replace OCT4 and SOX2, the core regulators of cell pluripotency. The authors further proposed a “seesaw model” to illustrate the complex process of the pluripotency state and lineage specification. The results were published in the May 23rd issue of Cell, titled “Induction of Pluripotency in Mouse Somatic Cells with Lineage Specifiers”.

OriGene’s cDNA clone collection was a critically important tool in this research. The authors performed high throughput functional screening using this collection of expression clones in a GFP-based reporter assay and quickly identified lineage specifiers as substitutes for OCT4 during reprogramming. The publication demonstrated the power of OriGene’s collection of high quality expression cDNA clones in the systematic screening of key gene regulators in a biological process.

“The collaboration with OriGene and the accessibility of this cDNA clone collection greatly accelerated our research.” said Dr. Hongkui Deng, the senior author of the article. “The results of this research will provide novel insights to our understanding of the balance between pluripotency and lineage determination.”

“OriGene is proud to be a contributor to this exciting research. After many successful applications of our clone collections in making novel discoveries, this study once again provides another proof-of-principle of using a large collection of over-expression cDNA clones to decipher gene functions.” said Dr. Youmin Shu, VP of R&D at OriGene. “We are excited that scientists are taking advantage of such collections. We believe this methodology will become routine for future discoveries.”

OriGene’s TrueClone collection of over 20,000 unique cDNA clones has empowered multiple pioneering groups to discover novel genes in major pathways through genome-scale biology. The Cell publication further validated the value of the TrueClone collection. The comprehensiveness of the collection and the expression-readiness of the cDNA clones make it the ideal source for high-throughput functional screening.

About OriGene Technologies

Since 1996, OriGene has been dedicated in creating TrueClone, the largest full-length cDNA collection for gene function study. OriGene’s flagship products are the TrueClone Collection, a searchable source of over 33,000 human full-length cDNA clones suitable for transfection and protein expression and TrueORF clones of over 25,000 tagged human ORF clone. With the comprehensive cDNA clones as foundation, OriGene has created the multiple unique research tools, including the largest offering of 8,000 recombinant proteins made from human cells, 6,000 TrueMAB monoclonal antibodies made with full-length human antigens. More information about OriGene Technologies can be found at the company’s website http://www.origene.com/.

For additional information regarding this announcement, please contact:

Youmin Shu, Ph.D.
240-620-0240
VP, Research and Development
OriGene Technologies

Read the full story at http://www.prweb.com/releases/origene/ipsc/prweb10791039.htm.


'/>"/>
Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

Related biology technology :

1. Steps for Getting Rid of Bed Bugs without Using Chemicals and Avoiding Them While Traveling Enumerated by My Cleaning Products in Its Latest Post
2. ASGCT Annual Meeting to Highlight Latest Advances in Genetic and Cellular Therapeutics
3. Latest Advances in Treatment for Alzheimers, Traumatic Brain Injury and Stroke to Be Presented at Symposium
4. Online Courses Address Latest Healthcare Compliance Regulations
5. The Return of Extinct Animals – and Maybe Humans; Latest Topic by HuffPost Columnist and Sociologist Gini Graham Scott
6. Leading Photonics and Laser Researchers to Present Latest Work at SPIE Optics + Optoelectronics
7. Douglas Harrington, MD Addresses Select Group Of Physicians Regarding Latest Advances In Cardiovascular Risk Assessment
8. PolyScience to Exhibit Its Latest Liquid Temperature Control Solutions at Pittcon 2013
9. Latest Environmental Research Featured at ScienceAlerts.com
10. New CfPIE Website Highlights Life Science Training Options for the Latest FDA Guidances and Standards
11. Cieri Media Announces New Science Series 'Bright Ideas' Focusing on Latest Inventions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2017)... YORK , March 23, 2017 ... ... of death, putting significant strain on health care systems, in ... cancer diagnoses rises, so too does the development of innovative ... minimum side effects. Among the many types of cancer treatments, ...
(Date:3/23/2017)... March 23, 2017 In today,s ... equities in the Biotech industry: Sangamo Therapeutics Inc. (NASDAQ: ... (NYSE MKT: SYN), and Regulus Therapeutics Inc. (NASDAQ: ... 2017, Credit Suisse upgraded its rating on Pharmaceuticals/Biotechnology to "Overweight" from "Market ... free report at: ...
(Date:3/22/2017)... (PRWEB) , ... March 22, 2017 , ... ... up human tissue regeneration from small lab samples to full-size tissues, bones, even ... to establish a vascular system that delivers blood deep into the developing tissue. ...
(Date:3/22/2017)... 2017 Good Start Genetics, a leading family ... 130 million covered lives mark through its most recent ... Texas . With newly signed contracts nationally and ... strong payor acceptance based on the quality of its ... counseling, its industry-leading customer care and support and its ...
Breaking Biology Technology:
(Date:2/28/2017)... -- News solutions for biometrics, bag drop and New ... At ... 16 March, Materna will present its complete end-to-end passenger journey, ... a real benefit for passengers. To accelerate the whole passenger ... point solutions to take passengers through the complete integrated process ...
(Date:2/22/2017)... With the biometrics market to exceed ... technologies that innovative and agile startups must incorporate ... the changing competitive landscape: multifactor authentication (MFA), point-of-sale ... "Companies can no longer afford to cut ... Dimitrios Pavlakis , Industry Analyst at ABI Research. ...
(Date:2/13/2017)... 13, 2017  RSA Conference -- RSA, a Dell ... designed to enhance fraud detection and investigation across ... RSA Fraud & Risk Intelligence Suite. The new ... additional insights from internal and external sources as ... their customers from targeted cybercrime attacks. ...
Breaking Biology News(10 mins):