Navigation Links
Latest Cell Publication of OriGene and Peking University Collaborative Discovery of New iPSC Reprogramming Factors
Date:6/3/2013

Rockville, MD (PRWEB) June 03, 2013

Scientists from Peking University, China and OriGene Technologies jointly published that multiple lineage specifier genes can replace OCT4 and SOX2, the core regulators of cell pluripotency. The authors further proposed a “seesaw model” to illustrate the complex process of the pluripotency state and lineage specification. The results were published in the May 23rd issue of Cell, titled “Induction of Pluripotency in Mouse Somatic Cells with Lineage Specifiers”.

OriGene’s cDNA clone collection was a critically important tool in this research. The authors performed high throughput functional screening using this collection of expression clones in a GFP-based reporter assay and quickly identified lineage specifiers as substitutes for OCT4 during reprogramming. The publication demonstrated the power of OriGene’s collection of high quality expression cDNA clones in the systematic screening of key gene regulators in a biological process.

“The collaboration with OriGene and the accessibility of this cDNA clone collection greatly accelerated our research.” said Dr. Hongkui Deng, the senior author of the article. “The results of this research will provide novel insights to our understanding of the balance between pluripotency and lineage determination.”

“OriGene is proud to be a contributor to this exciting research. After many successful applications of our clone collections in making novel discoveries, this study once again provides another proof-of-principle of using a large collection of over-expression cDNA clones to decipher gene functions.” said Dr. Youmin Shu, VP of R&D at OriGene. “We are excited that scientists are taking advantage of such collections. We believe this methodology will become routine for future discoveries.”

OriGene’s TrueClone collection of over 20,000 unique cDNA clones has empowered multiple pioneering groups to discover novel genes in major pathways through genome-scale biology. The Cell publication further validated the value of the TrueClone collection. The comprehensiveness of the collection and the expression-readiness of the cDNA clones make it the ideal source for high-throughput functional screening.

About OriGene Technologies

Since 1996, OriGene has been dedicated in creating TrueClone, the largest full-length cDNA collection for gene function study. OriGene’s flagship products are the TrueClone Collection, a searchable source of over 33,000 human full-length cDNA clones suitable for transfection and protein expression and TrueORF clones of over 25,000 tagged human ORF clone. With the comprehensive cDNA clones as foundation, OriGene has created the multiple unique research tools, including the largest offering of 8,000 recombinant proteins made from human cells, 6,000 TrueMAB monoclonal antibodies made with full-length human antigens. More information about OriGene Technologies can be found at the company’s website http://www.origene.com/.

For additional information regarding this announcement, please contact:

Youmin Shu, Ph.D.
240-620-0240
VP, Research and Development
OriGene Technologies

Read the full story at http://www.prweb.com/releases/origene/ipsc/prweb10791039.htm.


'/>"/>
Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

Related biology technology :

1. Steps for Getting Rid of Bed Bugs without Using Chemicals and Avoiding Them While Traveling Enumerated by My Cleaning Products in Its Latest Post
2. ASGCT Annual Meeting to Highlight Latest Advances in Genetic and Cellular Therapeutics
3. Latest Advances in Treatment for Alzheimers, Traumatic Brain Injury and Stroke to Be Presented at Symposium
4. Online Courses Address Latest Healthcare Compliance Regulations
5. The Return of Extinct Animals – and Maybe Humans; Latest Topic by HuffPost Columnist and Sociologist Gini Graham Scott
6. Leading Photonics and Laser Researchers to Present Latest Work at SPIE Optics + Optoelectronics
7. Douglas Harrington, MD Addresses Select Group Of Physicians Regarding Latest Advances In Cardiovascular Risk Assessment
8. PolyScience to Exhibit Its Latest Liquid Temperature Control Solutions at Pittcon 2013
9. Latest Environmental Research Featured at ScienceAlerts.com
10. New CfPIE Website Highlights Life Science Training Options for the Latest FDA Guidances and Standards
11. Cieri Media Announces New Science Series 'Bright Ideas' Focusing on Latest Inventions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/15/2017)... (PRWEB) , ... August 15, 2017 , ... ... of the largest Asian exhibitions for analytical and scientific instruments. This year’s symposium, ... be “New Approaches in Mass Spectrometry for Bioanalytical Applications.” This dynamic presentation will ...
(Date:8/15/2017)... (PRWEB) , ... August 15, 2017 , ... ... encrypted shopping cart. Now mobile responsive, the new website makes it easy to ... anywhere in between. Users can now find detailed product information, educational industry content ...
(Date:8/11/2017)... San Antonio, Texas (PRWEB) , ... August 11, 2017 , ... ... launching a rebranding campaign this month that will incorporate important key elements including a ... to thank the community that has supported them, Bill Miller has partnered with the ...
(Date:8/10/2017)... ... August 09, 2017 , ... The ... the clinic is here. The team at Capricor Therapeutics, Inc. utilized a cardiosphere-derived ... clinical studies. , Dr. Travis Antes, head of analytical development at Capricor ...
Breaking Biology Technology:
(Date:3/29/2017)... 2017  higi, the health IT company that operates ... America , today announced a Series B investment ... EveryMove. The new investment and acquisition accelerates higi,s strategy ... transform population health activities through the collection and workflow ... higi collects and secures data today on behalf of ...
(Date:3/24/2017)... March 24, 2017 The Controller General of Immigration ... Abdulla Algeen have received the prestigious international IAIR Award for ... Continue Reading ... ... Deputy Controller Abdulla Algeen (small picture on the right) have received the ...
(Date:3/23/2017)... Research and Markets has announced the addition of the "Global ... 2025" report to their offering. ... The Global Vehicle Anti-Theft System Market is ... next decade to reach approximately $14.21 billion by 2025. ... all the given segments on global as well as regional levels ...
Breaking Biology News(10 mins):