Navigation Links
Laser dissection of depression
Date:4/22/2008

Chinese investigators from Hefei and Dutch researchers in Amsterdam have collaborated using for the first time a combination of new elegant methodology in Depression research. They used postmortem human brain tissue that was donated to the Netherlands Brain Bank for research purposes and investigated a region in the basal part of the brain, the hypothalamus, that is known to be of crucial importance for the development of symptoms of depression. This region is 6 mm3 large and is called the Paraventricular Nucleus (PVN) since it is situated along the third ventricle of the brain. This brain area is central in the regulations of our normal stress response, while a too high activity of the PVN is a pivotal characteristic of depression. The hypothalamus consists of a large number of very small specialized cell groups that all have different functions and should thus be studied separately, hence the necessity of the application of the methodology used.

Corticotrophin-releasing factor (CRF) cells in the PVN of human hypothalamus are the central driving force of the stress response and are hyperactive in depression. The investigators sampled the PVN using new technology in psychiatry to study its molecular changes related to CRF. Frozen hypothalami of 7 depressed patients and 7 controls of the same age, the same sex and obtained the same time after death. The frozen brain structures were serially sectioned and the PVN was dissected using a microscope with a laser beam. The micro-laser-dissected material was subsequently studied with a very sensitive and specific quantitative molecular technique for the analysis of gene expression (qPCR). From the 16 gene products that were studied, because they were presumed to be involved in CRF activation in depression, 5 were found to show significant changes. The molecular changes found may not only explain the hyperactivity of the CRF cells but may also be potential targets for new therapeutic strategies.


'/>"/>

Contact: Prof. Dick. F. Swaab
d.f.swaab@nin.knaw.nl
31-205-665-500
Molecular Psychiatry
Source:Eurekalert

Page: 1

Related biology technology :

1. Imaging Diagnostic Systems New Laser Breast Imaging Scanner Introduced in Malaysia
2. Largest Asian Cancer Hospital to Evaluate New CT Laser Breast Imaging System
3. Radio wave cooling offers new twist on laser cooling
4. Laser Energetics to Integrate BrightStar(TM) Alexandrite Lasers in Medical and Dental Applications
5. Harvard University engineers demonstrate quantum cascade laser nanoantenna
6. Alma Lasers Ranked 9th in Deloitte Technology Fast 50 Award
7. Imaging Diagnostic Systems Exhibits CT Laser Breast Imaging Results at Major Italian Multidisciplinary Breast Cancer Meeting
8. Ultrafast optical shutter is switched entirely by laser light
9. Laser Therapy Gives Smokers Hope for Successful New Years Resolution
10. Nikon Instruments Launches Fully-Automated A1 Confocal Laser Microscope Series
11. TRIA At-Home Laser Hair Removal Device Cleared by FDA
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/10/2017)... CALIFORNIA (PRWEB) , ... October 10, 2017 , ... ... technological innovation and business process optimization firm for the life sciences and healthcare ... BoxWorks conference in San Francisco. , The presentation, “Automating GxP Validation for ...
(Date:10/9/2017)... , Oct. 9, 2017  BioTech Holdings announced ... by which its ProCell stem cell therapy prevents ... ischemia.  The Company, demonstrated that treatment with ProCell ... limbs saved as compared to standard bone marrow ... HGF resulted in reduction of therapeutic effect.  ...
(Date:10/9/2017)... , ... October 09, 2017 , ... At its national ... Christopher Stubbs, a professor in Harvard University’s Departments of Physics and Astronomy, has been ... a member of the winning team for the 2015 Breakthrough Prize in Fundamental physics ...
(Date:10/9/2017)... ... October 09, 2017 , ... ... 5, 2017, in the medical journal, Epilepsia, Brain Sentinel’s SPEAC® System which ... video EEG, in detecting generalized tonic-clonic seizures (GTCS) using surface electromyography (sEMG). ...
Breaking Biology Technology:
(Date:6/14/2017)... (NYSE: IBM ) is introducing several innovative partner startups ... collaboration between startups and global businesses, taking place in ... nine startups will showcase the solutions they have built with ... France is one of the ... percent increase in the number of startups created between 2012 ...
(Date:5/16/2017)... May 16, 2017  Veratad Technologies, LLC ( www.veratad.com ... age and identity verification solutions, announced today they will ... 2017, May 15 thru May 17, 2017, in ... International Trade Center. Identity impacts the ... in today,s quickly evolving digital world, defining identity is ...
(Date:5/6/2017)... -- RAM Group , Singaporean based technology ... biometric authentication based on a novel  quantum-state ... perform biometric authentication. These new sensors are based on a ... Group and its partners. This sensor will have widespread ... security. Ram Group is a next generation sensor ...
Breaking Biology News(10 mins):