Navigation Links
Large-scale genetic study sheds new light on lung cancer
Date:10/22/2008

A multi-institution team, funded by the National Human Genome Research Institute (NHGRI) of the National Institutes of Health (NIH), today reported results of the largest effort to date to chart the genetic changes involved in the most common form of lung cancer, lung adenocarcinoma. The findings should help pave the way for more individualized approaches for detecting and treating the nation's leading cause of cancer deaths.

In a paper published in the Oct. 23 issue of the journal Nature, the Tumor Sequencing Project (TSP) consortium identified 26 genes that are frequently mutated in lung adenocarcinoma -- an achievement that more than doubles the number of genes known to be associated with the deadly disease. But the pioneering effort involved far more than just tallying up genes. Using a systematic, multi-disciplinary approach, the TSP team also detailed key pathways involved in the disease, and described patterns of genetic mutations among different subgroups of lung cancer patients, including smokers and never-smokers.

More than 1 million people worldwide die of lung cancer each year, including more than 150,000 in the United States. Lung adenocarcinoma is the most frequently diagnosed form of lung cancer. The average 5-year survival rate currently is about 15 percent, with survival being longest among people whose cancer has been detected early.

"By harnessing the power of genomic research, this pioneering work has painted the clearest and most complete portrait yet of lung cancer's molecular complexities. This big picture perspective will help to focus our research vision and speed our efforts to develop new strategies for disarming this common and devastating disease," said NHGRI Acting Director Alan E. Guttmacher, M.D.

Like most cancers, lung adenocarcinoma arises from changes that accumulate in people's DNA over the course of their lives. However, little is known about the precise nature of these DNA changes
'/>"/>

Contact: Geoff Spencer
spencerg@mail.nih.gov
301-402-0911
NIH/National Human Genome Research Institute
Source:Eurekalert

Page: 1 2 3 4 5

Related biology technology :

1. Complete Genomics Launches, Becomes Worlds First Large-Scale Human Genome Sequencing Company
2. SAFC Pharma Completes Large-Scale API Manufacturing Expansion in Ireland
3. Large-scale community protein annotation -- WikiProteins
4. China-Biotics, Inc. Receives Approval to Begin Construction on Large-Scale Manufacturing Facility
5. A Large-Scale Research Project by a Dutch Consortium Addressing a Global Problem
6. MedImmune Licenses Reverse Genetics Technology to Hungarys Omninvest for Use in Influenza Vaccine Development and Production
7. Genetic Engineering & Biotechnology News reports on growing role of molecular diagnostics
8. FDA Accepts New Drug Application for Bucindolol, A Genetically-Targeted Treatment for Heart Failure From ARCA biopharma
9. Genetically Modified Canola Plantings Reach 90 Percent in Canada
10. Exosome Diagnostics Appoints Johan Skog, Ph.D., as Director of Genetics Research
11. A Better Tomorrow Treatment Center Inc., Forterus Inc.s Behavioral Healthcare Subsidiary, is the First in the Nation to Offer DNA-Customized Treatment for Individuals with a Genetic Predisposition for Addictive Behavior
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2014)... RICHMOND, Calif., July 23, 2014  Sangamo BioSciences, Inc. ... quarter 2014 financial results and accomplishments. ... reported a consolidated net loss of $7.0 million, or ... $5.5 million, or $0.10 per share, for the same ... Company had cash, cash equivalents, marketable securities and interest ...
(Date:7/23/2014)... -- Think Drinks are a neuroscience-backed drink regimen developed ... are the first functional focus beverage to give users ... to the temporary fix associated with energy drinks. truBrain ... 2014, with hopes to raise $50,000 over the course ... http://photos.prnewswire.com/prnh/20140723/129697 Think Drinks were designed ...
(Date:7/23/2014)... , July 23, 2014  Having the right people ... vital to accelerating business growth and achieving clinical and ... Association (AHA) Leadership Summit, July 20-22, 2014, in ... of hospital executives and healthcare experts discussing how partnerships ... Carrocino , President & Chief Executive Officer of Cape ...
(Date:7/23/2014)... 23, 2014 DuPont Pioneer announced today ... vice president of Agricultural Biotechnology (ABT), effective July 21, ... served most recently as president, chief executive officer and ... leadership in the seed and crop protection industry to ... E. Schickler , president of DuPont Pioneer. “I am ...
Breaking Biology Technology:Sangamo BioSciences Reports Second Quarter 2014 Financial Results 2Sangamo BioSciences Reports Second Quarter 2014 Financial Results 3Sangamo BioSciences Reports Second Quarter 2014 Financial Results 4Sangamo BioSciences Reports Second Quarter 2014 Financial Results 5Sangamo BioSciences Reports Second Quarter 2014 Financial Results 6Sangamo BioSciences Reports Second Quarter 2014 Financial Results 7Sangamo BioSciences Reports Second Quarter 2014 Financial Results 8Sangamo BioSciences Reports Second Quarter 2014 Financial Results 9truBrain Neuroscientists To Launch More Effective, Healthier Alternative To Energy Drinks On Indiegogo 2MSC and Cape Regional Medical Center Partner to Improve Cost, Quality and Outcomes 2DuPont Pioneer Names Neal Gutterson to Lead Agricultural Biotechnology 2DuPont Pioneer Names Neal Gutterson to Lead Agricultural Biotechnology 3
... Partners announced,today that it has initiated coverage on ... promising drug development pipeline for treating a,variety of ... on two,drug development programs; the first is MN-221 ... estimated 2,000,000 visits to the emergency room,a year ...
... Third Party Administrators,Alliance (TPAA) announced today the appointment ... the nation,s first alliance of third party,administrators and ... to its members., Oelschlager brings hands-on experience ... role, assets he believes will further the,organization,s reach ...
... PRXL ), a leading global biopharmaceutical services,organization, ... Goldberg, M.D.,to Chief Operating Officer (COO). Dr. Goldberg ... Perceptive Informatics at,PAREXEL. He will continue to oversee ... von Rickenbach, Chairman and Chief Executive Officer of ...
Cached Biology Technology:Vista Partners Initiates Coverage on MediciNova Inc. (Nasdaq: MNOV) 2The TPAA Names Mark Oelschlager President 2PAREXEL Promotes Dr. Mark A. Goldberg to Chief Operating Officer 2PAREXEL Promotes Dr. Mark A. Goldberg to Chief Operating Officer 3PAREXEL Promotes Dr. Mark A. Goldberg to Chief Operating Officer 4
(Date:7/24/2014)... researchers led by the University of York has carried ... the Western Indian Ocean. , The results, reported ... a revolution in the management of marine protected areas, ... 11,000 km in the region now under local ... of the seas and coasts designed to protect wildlife ...
(Date:7/24/2014)... from Singapore have developed Asia,s first genetic test for ... affects the cornea called corneal stromal dystrophy which can ... Called the POLARIS TGFBI (Transforming Growth Factor beta Induced) ... the diagnosis and management of patients with corneal stromal ... TGFBI mutation who may also be at risk of ...
(Date:7/23/2014)... new study of identical twins has found that early ... study, in the journal Child Development , was ... King,s College London. , "Since reading is an ability ... reading instruction," according to Stuart J. Ritchie, research fellow ... the study. "Early remediation of reading problems might aid ...
Breaking Biology News(10 mins):Western Indian Ocean communities play vital role in conservation 2Singapore team develops Asia's first genetic test that can prevent corneal blindness 2Singapore team develops Asia's first genetic test that can prevent corneal blindness 3Stronger early reading skills predict higher intelligence later 2
... revealed a previously unknown mechanism in the body which ... responses and control of blood pressure, pain and appetite. ... help fight health problems connected with these functions in ... and University College London found that lactate essentially ...
... New York, NYFebruary 10, 2014In a study published ... team led by Ken Shepard, professor of electrical ... Lars Dietrich, assistant professor of biological sciences at ... the basis of modern computers and communications devices, ...
... change unfolds over the next century, plants and animals will ... climate. A new study provides an innovative global map of ... up with a changing climate. The findings appear in the ... a UC Santa Barbara National Center for Ecological Analysis and ...
Cached Biology News:New research sheds light on how the body regulates fundamental neuro-hormone 2Chips that listen to bacteria 2Maps show expected redistribution of global species due to climate change 2Maps show expected redistribution of global species due to climate change 3
... MasterAmp™ Taq DNA Polymerase is a ... aquaticus. Having optimal activity at temperatures ... thermostable enzyme used for PCR and ... purpose. The enzyme has an intrinsic ...
... 4100 high pressure dual piston pump and the ... and utra low drift. The WaveQuest ... detection and provides superior stability. Hence ... and for monitoring to the highest of sensitivities. ...
Rabbit anti Xanthine Oxidase Xanthine Oxidase, Bovine Buttermilk...
... This CLS number ... number, created to easily ... If showing no availability ... the old Sigma-Aldrich number ...
Biology Products: