Navigation Links
LX211 highlighted as potential disease modifying therapy for noninfectious uveitis
Date:10/29/2009

ltimately to improved outcomes in this difficult-to-treat condition."

Results of the LX211-01 study, which investigated LX211 in 218 patients with active, sight-threatening uveitis affecting the posterior segment of the eye, will also be presented at AAO on Monday October 26 at 9:00 am PT by clinical investigator Quan D. Nguyen, M.D., of the Wilmer Eye Institute at The Johns Hopkins University, Baltimore, MD. "In this study, also a double-masked, placebo-controlled, dose-ranging trial conducted in North America, Europe and India, control of inflammation was evaluated by means of change in vitreous haze at weeks 16 and 24. Results showed the LX211 presumed label dose of 0.4 mg/kg twice daily to be statistically significantly superior to placebo at both time points. Preservation of vision was also demonstrated in this study."

In explaining the overall clinical benefit, C. Stephen Foster, MD, President, Massachusetts Eye Research and Surgery Institution (MERSI), highlighted the ability of LX211 to control inflammation and to significantly delay recurrence of inflammatory exacerbation compared to the control group. Moreover, this result was achieved while successfully reducing corticosteroids to 5 mg/day or less. "Therapy with LUVENIQ conforms to the 2000 uveitis treatment guidelines, and is supported by randomized clinical trials that offer the highest level of evidence-based support. Once approved, LUVENIQ would be the only uveitis therapy so rated and thus, one that should always be offered," Dr. Foster stated in his presentation to the AUS on Sunday October 25 at 8:00 pm PT.

Treatment with LX211 was overall well tolerated at the twice-daily 0.4 mg/kg dose, demonstrating a safety profile that appears suitable for chronic use. Adverse effects on renal function (8.2% of subjects with decrease from baseline of ≥30% in glomerular filtration rate vs. 4.1 % in placebo) and blood pressure (mean increase in systolic BP by 6 mm Hg) were moder
'/>"/>

Contact: Joan Kureczka
JKureczka@comcast.net
415-821-2413
Kureczka/Martin Associates
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. Sugarcane as a Key Element Against Global Warming to be Highlighted at Green Week in Brussels
2. Bio-Matrix Scientific Group, Inc. Highlighted in LifeSciencesWorld.com Special Report; Stem Cell Market Projected to Exceed $8 Billion Worldwide by 2016
3. Inverseons Asthma Therapy Receives Notice of Allowance; Clinical Trial Highlighted in Lancet
4. Significant Anti-Tumor Activity and Extended Half-Life of NKTR-102 (PEG-irinotecan) Highlighted in Phase 1 Data Presented at EORTC-NCI-AACR Symposium
5. Pharmaxis Research Programs Highlighted at European Respiratory Society Congress
6. Pressure Cycling Technology (PCT) Highlighted in Five Podium Presentations at the Fifth International Conference on High Pressure; PBI Introduces the Patent-pending PCT Shredder at the Meeting
7. Epeius Biotechnologies Lead Product, Rexin-G for Metastatic Cancer, Aptly Highlighted by National Cancer Institute Journal
8. Depth of MedImmunes Respiratory Disease Research Program Highlighted at Annual Meeting of the American Thoracic Society
9. Nektars PEGylation Technology Enables Peptide Mimetic, Highlighted by Data Presented at 45th ERA-EDTA Congress
10. Stereotaxis Market Leadership Highlighted at Heart Rhythm 2008
11. Arius highlighted at AACR-NCI-EORTC 2007 International Cancer Conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/26/2015)... 2015 The Market Element LLC, a ... alliance with Designing Gig LLC to provide website design, ... , “Forging this alliance with Designing Gig represents a ... extend a comprehensive, end-to-end, digital solution for our clients, ... said Chuck Miller, president of The Market Element. “For ...
(Date:3/26/2015)... LANSING, Mich., March 26, 2015 Neogen Corporation ... income for the third quarter of fiscal 2015, which ... to the prior year,s $6,575,000. Earnings per share in ... year ago. Current year-to-date net income increased 17% over ... to $20,621,000, or $0.56 per share, for the same ...
(Date:3/26/2015)... "In America," the popular news television program that ... hosted by legendary film actor James Earl Jones, has announced ... upcoming segment. , Botany is commonly described as the ... quite a bit more complicated than that. Scientists and other ... organisms, from the smallest bacteria known to man to the ...
(Date:3/25/2015)... pharmaceutical market is one of the most ... its absolute size, plus a growing economy and increasing ... Business Monitor International. The Russian market is set to ... market, with growth estimates around 10-15% annually reaching an ... About Green Cross Green Cross provides ...
Breaking Biology Technology:The Market Element LLC and Designing Gig LLC Form Strategic Alliance 2Neogen reports 13% increase in net income 2Neogen reports 13% increase in net income 3Neogen reports 13% increase in net income 4Neogen reports 13% increase in net income 5Neogen reports 13% increase in net income 6Neogen reports 13% increase in net income 7Neogen reports 13% increase in net income 8
... , ... Researchers in New Brunswick Scientific's ... high antibiotic expression levels in a pilot-scale fermentation process ... with,touchscreen interface augmented by the powerful supervisory capabilities of ...
... , ... new cell-growth matrix that dramatically increase yields in packed-bed reactors, and,have ... bags. New Brunswick,Scientific offers two new devices that use FibraCel disks ... system that outperforms spinners, T-flasks and roller bottles, and the CelliGen ...
... , Many of ... application in cell culture and fermentation. ... or antigen from a sample (from,serum, for example) by adding the corresponding antigen or ... of substances in solution or suspension, to ...
Cached Biology Technology:Rapamycin Optimized in 100 Liter Fermentor Using BioCommand Control Strategys 2Rapamycin Optimized in 100 Liter Fermentor Using BioCommand Control Strategys 3A technique for increasing yields in bioreactors and disposable cell-culture systems 2A technique for increasing yields in bioreactors and disposable cell-culture systems 3A technique for increasing yields in bioreactors and disposable cell-culture systems 4Glossary for The BioPharm Guide to Fermentation and Cell Culture 2Glossary for The BioPharm Guide to Fermentation and Cell Culture 3Glossary for The BioPharm Guide to Fermentation and Cell Culture 4Glossary for The BioPharm Guide to Fermentation and Cell Culture 5Glossary for The BioPharm Guide to Fermentation and Cell Culture 6Glossary for The BioPharm Guide to Fermentation and Cell Culture 7Glossary for The BioPharm Guide to Fermentation and Cell Culture 8Glossary for The BioPharm Guide to Fermentation and Cell Culture 9Glossary for The BioPharm Guide to Fermentation and Cell Culture 10Glossary for The BioPharm Guide to Fermentation and Cell Culture 11Glossary for The BioPharm Guide to Fermentation and Cell Culture 12Glossary for The BioPharm Guide to Fermentation and Cell Culture 13Glossary for The BioPharm Guide to Fermentation and Cell Culture 14Glossary for The BioPharm Guide to Fermentation and Cell Culture 15Glossary for The BioPharm Guide to Fermentation and Cell Culture 16
(Date:3/20/2015)... DUBLIN , Mar. 20, 2015 Research ... announced the addition of the "India Sensors ... their offering. The sensor market is ... through 2020 Consumer electronics, automotive, industrial ... for sensors in the country. In addition, adoption ...
(Date:3/18/2015)... Florida , March 18, 2015 ... as businesses, new revolutionary smart wallets and apps continue to ... Companies currently entrenched in the mobile payment industry in focus ... Group Holding Ltd. (NYSE: BABA ), Apple Inc. ... GOOG ) and Facebook Inc. (NASDAQ: FB ) ...
(Date:3/12/2015)... -- IriTech, a leading iris based identity management technology ... Design Network, announced today that the Chief Minister ... MK2120U device during a launching event of Andhra Pradesh ... The iris scanner is manufactured by U.S. based ... India through its Indian partner, Biometronic Technology, ...
Breaking Biology News(10 mins):India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 2India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 3Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 2Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 3Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 4Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 5Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 6Indian States See IriTech's Scanner Bolstering Efficiency of Authentication for Aadhaar 2Indian States See IriTech's Scanner Bolstering Efficiency of Authentication for Aadhaar 3
... Disease Models & Mechanisms, one-day symposium entitled Protein-Folding ... one-day Symposium will focus on how misfolded proteins ... cellular and whole-organism level, highlighting the diverse biological ... issue. It is becoming increasingly clear that protein ...
... birds and fish use the Earth,s magnetic field to ... with internal compass needles for the perception of the ... the magnetic orientation. Although many animal species can ... orientation, efforts to pinpoint the cells that detect the ...
... twists and turns of rivers can easily be seen. In ... vessels is difficult, but important. Vessel "bendiness" can indicate the ... UNC scientists to a new method of using a high-resolution ... method, based on vessel bendiness or "tortuosity," potentially offers an ...
Cached Biology News:The magnetic sense 2Preclinical studies use specialized ultrasound to detect presence of cancer 2
Prostaglandin E2 Luminex Standard Product Lines: Unspecified...
Agarose-ME, 500 g. Suitable for immunoelectrophoresis.Gel point (1.5%): 36 1.5 C, EEO (-mr): 0.16-0.19, Gel strength (1%): > 1000 g/cm2. Category: Nucleotides & Enzymes & Biochemicals, Ultrapure Bio...
ERalpha (Ser 104/106)...
... Phosphatase, Calf Intestinal (CIAP), catalyzes the hydrolysis ... ribo- and deoxyribonucleoside triphosphates. This enzyme is ... linearized cloning vector DNA by removing phosphate ... be used for the dephosphorylation of 5 ...
Biology Products: