Navigation Links
LC/MS Biomarker Assay Validation Strategies Using Surrogate Matrix and Surrogate Analyte Approaches, New Life Science Webinar Hosted by Xtalks
Date:9/27/2013

Toronto, Canada (PRWEB) September 27, 2013

As interest increases in developing novel biomarker and biotherapeutic assays to support clinical development, so does the need to keep up with the pace of new discoveries and evolving fit-for-purpose methods.

One major challenge is that quantitation of biomarkers by LC–MS/MS is complicated by the presence of endogenous analytes. This challenge is most commonly overcome by calibration using an authentic standard spiked into a surrogate matrix devoid of the target analyte. A second approach involves use of a stable-isotope-labeled standard as a surrogate analyte to allow calibration in the actual biological matrix. For both methods, parallelism between calibration standards and the target analyte in biological matrix must be demonstrated in order to ensure accurate quantitation.

This presentation will discuss a recent case involving LCMS Biomarkers and Biologics agency partnering with a sponsor to develop methods that compare the surrogate matrix and surrogate analyte approaches for the analysis of amino acids in human plasma. In addition, methodology based on standard addition will be introduced, which enables a robust examination of parallelism in both surrogate analyte and surrogate matrix methods prior to formal validation.

The speaker will present results from additional assays to introduce the standard-addition methodology and to highlight the strengths and weaknesses of each approach.

A Q&A with the audience will follow the main presentation.

For more information about this event or to register, visit: http://xtalks.com/Surrogate-Matrix-and-Surrogate-Analyte.ashx

Xtalks, powered by Honeycomb Worldwide Inc., is a leading provider of educational webinars to the global Life Sciences community. Every year thousands of industry practitioners turn to Xtalks for access to quality content. Xtalks helps Life Science professionals stay current with industry developments, trends and regulations. Xtalks webinars also provide perspectives on key issues from top industry thought leaders and service providers.

To learn more about Xtalks visit http://xtalks.com/ContactUs.ashx.

Contact:
Karen Lim (416) 977-6555 ext 227
clientservices(at)xtalks(dot)com

Read the full story at http://www.prweb.com/releases/2013/9/prweb11158839.htm.


'/>"/>
Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

Related biology technology :

1. Waters Unveils Industrys First Integrated LC/MS Platform for Proteins, Peptides, and Glycans Analysis at WCBP 2013
2. Biomarkers Market worth $40.8 Billion by 2018
3. Meso Scale Discovery Launches V-PLEX™ Multiplex Biomarker Immunoassays
4. Biomarkers: Technological and Commercial Outlook 2013-2023
5. Enhanced Strategies for Design and Execution of Biomarker-driven Oncology Trials, new life science webinar hosted by Xtalks
6. Optimizing Assays from FFPE for Biomarker Strategies, New Life Science Webinar Hosted by Xtalks
7. Biomarkers predict time to ovarian cancer recurrence
8. Epigenetic and MicroRNA Biomarkers 2013 Market Report
9. Biomarkers - Technologies, Markets and Companies - Updated 2012 Report
10. Molecular Biomarkers for Cancer Detection and Management
11. New Research from SRI International Points to Biomarker that Could Track Huntingtons Disease Progression
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/20/2017)... , ... April 20, 2017 , ... ... the scientific and clinical research community’s growing body of knowledge during its ... the Gracie Theatre and the adjacent Darling Atrium. During the event, undergraduates, graduate ...
(Date:4/20/2017)... LAVAL, QC , April 20, 2017 /PRNewswire/ - Prometic Life ... today presented new results at the International Liver Congress ("ILC") ... Liver ("EASL") in Amsterdam on the ... in a mouse model of obesity and metabolic syndrome. ... According to Dr. Lyne Gagnon, ...
(Date:4/20/2017)... CA (PRWEB) , ... April 20, 2017 , ... ... of clinical trials worldwide, announced today that they were named one of the ... which covers the latest developments in the pharmaceutical industry. , “We take pride in ...
(Date:4/20/2017)... April 20, 2017 Dutch philosopher Koert van Mensvoort - ... at the University of Technology in Eindhoven - has written a ,Letter ... he calls on humanity to avoid becoming a slave and victim to its ... ... Dutch philosopher Koert van Mensvoort – founder of the Next Nature ...
Breaking Biology Technology:
(Date:3/30/2017)... -- The research team of The Hong Kong Polytechnic ... by adopting ground breaking 3D fingerprint minutiae recovery and matching technology, ... accuracy for use in identification, crime investigation, immigration control, security of ... ... A research team led by Dr ...
(Date:3/29/2017)... , March 29, 2017  higi, the health IT ... North America , today announced a ... the acquisition of EveryMove. The new investment and acquisition ... of tools to transform population health activities through the ... data. higi collects and secures data today ...
(Date:3/27/2017)... March 27, 2017  Catholic Health Services (CHS) ... Systems Society (HIMSS) Analytics for achieving Stage 6 ... sm . In addition, CHS previously earned a ... using an electronic medical record (EMR). ... level of EMR usage in an outpatient setting.  ...
Breaking Biology News(10 mins):