Navigation Links
Kuvan, Naglazyme and Aldurazyme Data to Be Presented at the 57th Annual Meeting of the American Society of Human Genetics
Date:10/17/2007

sion study reported safety and

efficacy data of the 24-week pivotal Phase 3 trial, followed by a

72-week extension study for a total of 96 weeks.

-- Endpoints included 12-minute-walk-test (12MWT), 3-minute-stair-climb

(3MSC), level of urinary glycosaminoglycans (GAGS) and pulmonary

function.

-- Patients receiving Naglazyme improved by a mean of 183 m +/- 26 m from

baseline to week 96 in the 12MWT (p<0.001).

-- The placebo group, which was switched to active drug at week 24,

improved by a mean of 117 m +/- 25 m from week 24 to week 96 (p<0.001).

-- Similar improvements in the rate of stairs climbed (3MSC) were also

observed (p<0.001).

-- A sustained reduction in urinary GAGs was observed in both treatment

groups.

-- Several pulmonary function measures showed improvement at Week 96,

including forced vital capacity (FVC), which improved 0.11 L +/- 0.05 L

(p=0.039) in the Naglazyme group from baseline and improved 0.07 L +/-

0.02 L (p<0.001) in the placebo/Naglazyme group from Week 24.

-- Safety data for the extension study was similar to that measured in the

first 24 weeks of treatment. The overall safety profile remained

favorable. Adverse events reported by the greatest number of patients

during the extension study included headache, cough, pyrexia, diarrhea,

arthralgia and extremity pain. None of the adverse events that

occurred during infusion were severe.

The following relevant posters will also be featured:

-- 2229 -- Safety of sapropterin dihydrochloride (sapropterin) in children

with phenylketonuria (PKU) on a phenylalanine (Phe)-restricted diet

(Grange)

-- 2230 -- Safety and efficacy of sapropterin dihydrochloride

(sapropterin) treatment over 22 weeks in patients with phenylketonuria

(PKU) (Randolph)

-- 2231 --
'/>"/>

SOURCE BioMarin Pharmaceutical Inc.
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related biology technology :

1. Wisconsin Assembly passes capital investment bill, revised CAPCO program not presented
2. NameProtect releases annual list of top trademarkers
3. Doyle says new contracts saving state more than $16 million annually
4. Department of Commerce offers up to $1 million annually to aid tech entrepreneurs
5. Annual Bioethics Forum to explore genetic testing
6. Annual Conference Honors Tech Grant Winners
7. AG accuses BioCATT of violating meetings law
8. VC trends, company progress discussed at Mason Wells portfolio meeting
9. Beware the Dreaded Off-Site Technology Meeting
10. A disgusting video: U.S. companies sell out Americans
11. Northwestern Mutual, American Family make Computerworlds best IT workplaces
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/15/2014)... More than 5 million Americans are currently living ... will die with Alzheimer’s or another dementia, according to ... many Americans into looking for ways to improve their ... cognitive disorders. Jonathan Weisman, president of Biohack Pure, is ...
(Date:1/15/2014)... The Microcompetition with Foreign DNA theory explains ... these latent viruses is the Epstein Barr Virus (EBV), and ... (RA) is a chronic inflammatory disease that destroys the body’s ... RA patients have high concentrations of EBV DNA in their ...
(Date:1/15/2014)... Arizona (PRWEB) January 15, 2014 2013 ... for Scottsdale’s Brain State Technologies®. They saw continued independent ... Medical Center who were awarded a $1 million grant ... published in “Brain and Behavior” a peer reviewed journal, ...
(Date:1/15/2014)... ON (PRWEB) January 15, 2014 AudioNotch ... experimental new therapy for the treatment of tinnitus. Patients ... tinnitus frequency, and over a period of weeks to months, ... Sound Therapy in two forms: Notched Music and Notched White ...
Breaking Biology Technology:Biohack Pure Offers 5 Tips for Increasing Memory in 2014 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3
... , , ... , , Cell death as ... of cell numbers in adult,organisms, furthermore in eliminating cells damaged by,irradiation, ... of,eukaryotic cell death: oncosis and apoptosis. How cells,die does not so ...
... , , ... , , , ... DNA synthesis in cell,cultures is now a routine procedure in ... systems. The effects of growth,factors, inhibition of cell division by ...
... , ... , , , , ... dihydropyrimidine dehydrogenase (DPD), and thymidylate,synthase (TS) play a pivotal role ... compound 5-fluorouracil (5-FU) is the standard,chemotherapy treatment for a wide ...
Cached Biology Technology:Quantification of Nucleosomes in Serum,by the Cell Death Detection ELISAplus 2Quantification of Nucleosomes in Serum,by the Cell Death Detection ELISAplus 3Quantification of Nucleosomes in Serum,by the Cell Death Detection ELISAplus 4Quantification of Nucleosomes in Serum,by the Cell Death Detection ELISAplus 5Quantification of Nucleosomes in Serum,by the Cell Death Detection ELISAplus 6Quantitative Measurement of Cell Proliferation,Using the BrdU ELISA: A Comparison,Between Colorimetric and Chemiluminescent Detection 2Quantitative Measurement of Cell Proliferation,Using the BrdU ELISA: A Comparison,Between Colorimetric and Chemiluminescent Detection 3Quantitative Measurement of Cell Proliferation,Using the BrdU ELISA: A Comparison,Between Colorimetric and Chemiluminescent Detection 4Quantitative Measurement of Cell Proliferation,Using the BrdU ELISA: A Comparison,Between Colorimetric and Chemiluminescent Detection 5Quantitative Measurement of Cell Proliferation,Using the BrdU ELISA: A Comparison,Between Colorimetric and Chemiluminescent Detection 6Gene-Expression Analysis of TP, DPD, and TS Using,the LightCycler mRNA Quantification KitsPLUS 2Gene-Expression Analysis of TP, DPD, and TS Using,the LightCycler mRNA Quantification KitsPLUS 3Gene-Expression Analysis of TP, DPD, and TS Using,the LightCycler mRNA Quantification KitsPLUS 4
(Date:4/18/2014)... X-ray crystallography and nuclear magnetic resonance imaging (NMR) to ... but such efforts have long been hampered by the ... molecule and often in ordered and crystalized form to ... peer into the structure of most molecules. , Harvard ... thing of the past. , A team of ...
(Date:4/18/2014)... Seeds that sprout as soon as they,re planted may be ... be more careful. In the wild, a plant whose seeds ... risk disaster. More than just an insurance policy against late ... dormancy has long-term advantages too: Plants whose seeds put ... more species, finds in a team of researchers working at ...
(Date:4/17/2014)... A drug under clinical trials to treat tuberculosis ... drugs that act against various bacteria, fungal infections and ... University of Illinois chemists and collaborators. , Led by ... determined the different ways the drug SQ109 attacks the ... target other pathogens from yeast to malaria and ...
Breaking Biology News(10 mins):MRI, on a molecular scale 2MRI, on a molecular scale 3Plants with dormant seeds give rise to more species 2Multitarget TB drug could treat other diseases, evade resistance 2
... where two neurons communicate. Neurotransmitter molecules released from the ... terminal on the other, binding to receptors that lead ... and edited by experts in the field, The ... the highly complex structures of the pre- and postsynaptic ...
... Some deep-sea crabs have eyes sensitive to ultraviolet light, which ... in their mouths, a new Nova Southeastern University study suggests. ... at Nova Southeastern University,s Oceanographic Center, who is the principal ... zone --- a pitch dark area at the ocean bottom ...
... the players on your favourite football team were smaller than ... Left defenseless, they would become easy prey for other teams. ... water organisms vulnerable to their predators, which may pose a ... low calcium levels the organisms grow slower and cannot build ...
Cached Biology News:Deep-sea crabs seek food using ultraviolet vision 2Deep-sea crabs seek food using ultraviolet vision 3Changes in water chemistry leave lake critters defenseless 2
... Multidrop 384 offers lower consumption of ... screening applications. The Multidrop 384 is ... screening and microvolume dispensing into 384- ... outstanding flexibility. It can easily switch ...
...
... macromolecular structure has been determined, the challenge ... widely diverse audience of scientists, educators and ... and dissemination over the Internet, either via ... pages. Printed literature has the advantage of ...
Buckets for 2 racks of 5 tubes, type Stago/Hitachi...
Biology Products: