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Kosan's Hsp90 Inhibitor, Tanespimycin, Shows 55% Clinical Benefit in Patients With Trastuzumab-Refractory Metastatic Breast Cancer
Date:12/17/2007

owing administration of the standard dose of trastuzumab.

Of 26 patients enrolled in the trial, 20 were evaluable for efficacy (3 patients were not evaluable for efficacy and 3 patients are too early to assess). Of the 26 patients enrolled, 21 were treated with Kosan's prior Cremophor(R)-containing injection formulation of tanespimycin (4 of whom were crossed over to receive the recently introduced Injectable Suspension formulation), and 5 were treated with the Injectable Suspension formulation (3 of whom were recently enrolled and are not yet evaluable). Of the 20 patients evaluable for efficacy, 11 responded, yielding a clinical benefit rate of 55%.

-- 5 patients experienced confirmed partial responses, including,

-- 1 patient with 75% decrease in liver metastases with 42% drop in

CEA; 8 months on study;

-- 1 patient with 45% decrease in a hilar node, continuing on study

after 14 months;

-- 1 patient with 33% decrease in right breast lesions with decreased

tumor markers, continuing on study after 7 months;

-- 1 patient with 57% decrease in lymph nodes, liver and left breast

lesions, continuing on study after 7 months; and

-- 1 patient with 37% decrease in lymph nodes, continuing on study

after 5 months.

-- 2 patients experienced minor responses with decreased tumor markers (on

study for 6 and 5 months).

-- 4 patients had stable disease for 4, 4, 7, and 8 months.

Common toxicities were mainly Grade 1 and 2 and included diarrhea, fatigue, dizziness and headache. Treatment-related Grade 3 toxicities were experienced by 3 patients and included reversible fatigue and headache, increased liver function tests that resolved in 9 days and unsteady gait and euphoric mood that resolved in a single day. Noticeably absent were toxicities associated with conventional chemotherapy, including alopecia, mye
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SOURCE Kosan Biosciences Incorporated
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