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Kosan Appoints Pamela S. Cohen, M.D., as Chief Medical Officer
Date:5/20/2008

the global development and successful registration of several well-established cancer therapeutics. At Novartis, she served for close to 8 years in positions of increasing responsibility, including Executive Director, Oncology, where she was responsible for the supplemental new drug application (sNDA) registration filing of Gleevec(TM) in Ph+ adult acute lymphoblastic leukemia (ALL) and, as global clinical project leader, successfully brought the first FLT3 kinase inhibitor PKC412 (Midostaurin) to Phase 3 in acute myelogenous leukemia (AML). Earlier in her career at Novartis, Dr. Cohen was responsible for the early clinical development through Phase 1 and proof-of-concept at Novartis Oncology, and was an early proponent of the use of biomarkers to speed clinical decision making and optimize trial design. Dr. Cohen was also responsible for in-licensing activities for preclinical through Phases 1 to 3 oncology compounds and served as an in-house expert for pediatric oncology drug development. Prior to joining Novartis, Dr. Cohen held several academic positions in pediatric oncology at various institutions, including Cornell, UCLA, the National Cancer Institute, and Stanford University.

Dr. Cohen received her undergraduate degree from Barnard College, Columbia University and her medical degree from the Mount Sinai School of Medicine. She has received many awards and honors and has authored over 30 publications in the area of the molecular biology of pediatric and medical oncology, clinical development of targeted oncology therapeutics and the development of biomarkers for use in oncology drug development.

About Kosan

Kosan Biosciences is a biotechnology company advancing two new classes of anticancer agents through clinical development -- a Hsp90 (heat shock protein 90) inhibitor and an epothilone. Hsp90 inhibitors have a novel mechanism of action targeting multiple pathways involved in cancer cell growth and survival. Tanespimycin (KOS-953) is be
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