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Kosan Announces Third Quarter 2007 Financial Results
Date:11/8/2007

President and Chief Executive Officer. "We believe that the growing body of positive clinical data that we have generated in our clinical trials to date, combined with development and regulatory strategies that are being successfully implemented in all of our clinical programs and the commercial potential of our Hsp90 and epothilone programs, position Kosan as an attractive investment opportunity."

Third Quarter 2007 Highlights

-- Kosan reached a binding agreement with the U.S. Food and Drug

Administration (FDA) on the design of Kosan's TIME-1 clinical trial, a

pivotal Phase 3 trial of Kosan's Hsp90 inhibitor tanespimycin as a

treatment for patients with multiple myeloma, through a Special

Protocol Assessment (SPA) process with the FDA. Kosan also completed

the "Scientific Advice" process with the centralized European Medicines

Agency (EMEA) for TIME-1.

-- At the 2007 Breast Cancer Symposium of the American Society of Clinical

Oncology (ASCO), Kosan presented updated data from a Phase 1 clinical

trial showing that Kosan's Hsp90 inhibitor alvespimycin demonstrated

antitumor activity and tolerability in combination with trastuzumab

(Herceptin(R)), with clinical benefit observed in 42% of evaluable

patients (8 of 19 evaluable) with HER2-positive metastatic breast

cancer.

-- Pfizer Inc. initiated a Phase 1 clinical trial designed to test the

safety, tolerability and pharmacokinetics of motilin receptor agonist

KOS-2187, a selective and potent motilin receptor agonist being

developed for the treatment of gastroesophageal reflux disease (GERD)

and potentially other gastrointestinal disorders.

-- Kosan completed preparations and is planning to initiate later this

quarter a Phase 2 clinical trial of alvespimycin in patients with

newly-diagnosed HER2-positive metastatic breast cance
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SOURCE Kosan Biosciences Incorporated
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