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Kinase Market Profiling - In House & Outsourced Trends 2015 Forecast in New Research Report at

Dallas, Texas (PRWEB) May 24, 2013

This market report summarizes the industry-wide global web-based benchmarking survey on kinase profiling carried out in May 2013. The full report provides the data, details of the breakdown of the responses for each question, its segmentation and the estimates for the future (2015). It also highlights some interesting differences, particularly between Pharma, Biotech and Academic Research survey groupings. Two bottom-up models were developed to estimate the in house and outsourced kinase profiling markets. The in house kinase profiling reagent/kit market was estimated to be around $38Million in 2013. The outsourced kinase profiling market at fee-for-service providers was estimated to be around $34Million in 2013. The markets were segmented by organization and geography. CAGR estimates were made for the market segments.

The objective was to comprehensively document current practices and preferences in kinase selectivity profiling, and to understand future user requirements, particularly with respect to the cost and use of outsourced services. The aim was to compile a reference document on kinase profiling metrics. Equal emphasis was given to soliciting opinion from Pharma, Biotech and Academic Research market segments in both North America and Europe.

The survey looked at in house and outsourced kinase profiling - , as practiced today (2013) and in some cases as predicted for the future (2015). Specifically the following were investigated:

1.    therapeutic areas using kinase assays
2.    proportion of kinase profiling activities outsourced
3.    preferred kinase panel profiling assay format, reagent/kit supplier and outsourced fee-for-service providers
4.    interest in activity vs. binding assays
5.    satisfaction with data quality generated
6.    typical turnaround time
7.    most used/most likely to use outsourced fee-for-service providers
8.    key reasons for using a service provider
9.    decision-making criteria for selecting an outsourced provider
10.    outsourcing providers most associated with desired attributes
11.    kinase panel profiling budgets
12.    supplier market share for in house reagents/kits and outsourced profiling
13.    number of profiling wells generated in house and outsourced
14.    average cost per single well of the kinase profiling assays and typical use of kinase profiling
15.    data point breakdown between single vs. replicate testing and dose response curves
16.    typical size of the kinase panels used
17.    preferred size of an outsourced profiling panel
18.    representation of disease-relevant mutant kinases
19.    types of mode of action studies undertaken
20.     when a broad kinome profile is chosen
21.    use and interest in phosphoproteome analysis technologies
22.    interest in a panel of cell-based kinases
23.    features of an ideal kinase platform of greatest interest to respondents
24.    where kinase service providers should prioritize going forward
25.    the top 5 kinase genes most investigated today and those of greatest interest for the future
26.    key areas where service providers need to improve
27.    and any unmet needs in kinase panel profiling and related services today.

The main questionnaire consisted of 31 mainly simple multi-choice questions, focused mostly on assay and budget metrics. In addition, there were 8 questions related solely to survey demographics. The survey collected 78 validated responses, of these 73% provided comprehensive input. Responses were geographically split: 57% North America; 27% Europe; 14% Asia (excluding Japan); 1% ROW (Rest of World); and 1% Japan. Respondents came from 23 Biotech Companies; 15 Large Pharma; 11 Medium-Small Pharma; 8 Universities; 5 Virtual Biotech Companies; 4 Research Institutes; 4 Government Labs; 3 Not-For-Profit Research Centers; 3 Hospitals/Clinics/Medical Schools; 1 Academic Screening Center; and 1 Other. The research discipline of the majority of survey respondents was biology. Survey results were expressed as an average of all survey respondents.

In addition, the data was fully reanalyzed after sub-division into the following 5 survey groups: 1) Pharma; 2) Biotech; 3) Academic Research; 4) Europe; and 5) North America. 76% of respondents were currently undertaking kinase profiling assays in house or outsourcing at a feefor-service provider. The majority of kinase profiling was undertaken within the oncology therapeutic area. A median of 20%-40% of all kinase profiling activities were outsourced today (2013). The preferred in house kinase panel profiling assay format was activity assays and PerkinElmer was the preferred kinase panel profiling reagent/kit supplier. The preferred outsourced kinase panel profiling assay format was activity assays, and Life Technologies was the preferred fee-for-service provider. The majority thought that activity assays were preferable to binding assays, and the reasons given for preferring activity assays were documented. The majority were satisfied with the data quality generated by kinase profiling assay methods used both in house and outsourced. Reaction Biology and DiscoveRx were the most used fee-for service providers over the past year.

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