Navigation Links
Key to aging immune system is discovered
Date:7/31/2014

There's a good reason people over 60 are not donor candidates for bone marrow transplantation. The immune system ages and weakens with time, making the elderly prone to life-threatening infection and other maladies, and a UC San Francisco research team now has discovered a reason why.

"We have found the cellular mechanism responsible for the inability of blood-forming cells to maintain blood production over time in an old organism, and have identified molecular defects that could be restored for rejuvenation therapies," said Emmanuelle Passegu, PhD, a professor of medicine and a member of the Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research at UCSF. Passegu, an expert on the stem cells that give rise to the blood and immune system, led a team that published the new findings online July 30, 2014 in the journal Nature.

Blood and immune cells are short-lived, and unlike most tissues, must be constantly replenished. The cells that must keep producing them throughout a lifetime are called "hematopoietic stem cells." Through cycles of cell division these stem cells preserve their own numbers and generate the daughter cells that give rise to replacement blood and immune cells. But the hematopoietic stem cells falter with age, because they lose the ability to replicate their DNA accurately and efficiently during cell division, Passegu's lab team determined.

Especially vulnerable to the breakdown, the researchers discovered in their new study of old mice, are transplanted, aging, blood-forming stem cells, which lack the ability to make B cells of the immune system. These B cells make antibodies to help us fight all sorts of microbial infections, including bacteria that cause pneumonia, a leading killer of the elderly.

In old blood-forming stem cells, the researchers found a scarcity of specific protein components needed to form a molecular machine called the mini-chromosome maintenance helicase, which
'/>"/>

Contact: Jeffrey Norris
jeffrey.norris@ucsf.edu
415-502-6397
University of California - San Francisco
Source:Eurekalert  

Page: 1 2

Related biology technology :

1. Leveraging ‘Big Data’ - Methodological Considerations in Health Services Research, New Webinar Hosted by Xtalks
2. Fastec Imaging Introduces the First High Speed Camcorder
3. Introducing a New Bonus Treatment Cup for EvoDerma’s NOOME Anti-Aging Motion
4. Aging Population & Rising Incidence of Chronic Diseases to Drive the Global Mesenchymal Stem Cells Market, According to New Report by Global Industry Analysts, Inc.
5. Latest Technologies for Life-saving Applications on the Program at SPIE Medical Imaging
6. Studies Show Pterostilbene Shows Promise for Anti-Aging and Maintaining Healthy Brain
7. Founders Fund Backs Nanotronics Imaging
8. The Houston Methodist Human Performance Lab Launches Innovative Study on Triathletes, Investigating the Effects of Aging and Training Variables on Triathlon Performance
9. Smart Imaging Technologies and InvitroCue Team Up to Bring Digital Pathology to Asia
10. New venue, new conference, new courses, new technologies for Electronic Imaging 2014
11. Scientists accelerate aging in stem cells to study age-related diseases like Parkinsons
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Key to aging immune system is discovered
(Date:10/18/2014)... (PRWEB) October 18, 2014 The Asian Electronic ... market in Asian with analysis and forecast of revenue. The ... to grow to $2,328.0 million by 2018, at a CAGR ... TOC of the Asian Electronic Medical Record (EMR) market, to ... provides a glimpse of the segmentation of the market in ...
(Date:10/18/2014)... The report " Cloud Analytics Market [Cloud ... Machine; Video; Predictive Analytics: Global Advancements, Delivery Models, ... (2013 - 2018) ", defines and segments the ... with an in-depth analysis and forecasting of market ... this market, various restraints, and opportunities impacting it ...
(Date:10/17/2014)... 16—As in Alice,s journey through the looking-glass to Wonderland, ... surprising and unexpected ways, including a new class of ... reported today in The Optical Society,s (OSA) new high-impact ... for the first time, a new type of mirror ... reflects infrared light by using an unusual magnetic property ...
(Date:10/17/2014)... 2014 Bioquell, provider of germ-eliminating ... health facilities around the world to decontaminate locations ... Among the many places the hydrogen peroxide vapor ... Hospital Dallas and at the National Institutes of ... have been utilized to decontaminate patient rooms, equipment, ...
Breaking Biology Technology:The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 2The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 3The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 4The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 5Cloud Analytics Market (by Cloud Business Intelligence & Predictive Analytics) Expected to Cross $16.52 Billion by 2018 - New Report by MarketsandMarkets 2Cloud Analytics Market (by Cloud Business Intelligence & Predictive Analytics) Expected to Cross $16.52 Billion by 2018 - New Report by MarketsandMarkets 3Cloud Analytics Market (by Cloud Business Intelligence & Predictive Analytics) Expected to Cross $16.52 Billion by 2018 - New Report by MarketsandMarkets 4Cloud Analytics Market (by Cloud Business Intelligence & Predictive Analytics) Expected to Cross $16.52 Billion by 2018 - New Report by MarketsandMarkets 5Magnetic mirrors enable new technologies by reflecting light in uncanny ways 2Magnetic mirrors enable new technologies by reflecting light in uncanny ways 3Magnetic mirrors enable new technologies by reflecting light in uncanny ways 4Bioquell’s Vapor Producing Robots Selected to Combat Ebola in Hospitals Around the World 2Bioquell’s Vapor Producing Robots Selected to Combat Ebola in Hospitals Around the World 3Bioquell’s Vapor Producing Robots Selected to Combat Ebola in Hospitals Around the World 4Bioquell’s Vapor Producing Robots Selected to Combat Ebola in Hospitals Around the World 5Bioquell’s Vapor Producing Robots Selected to Combat Ebola in Hospitals Around the World 6
... - OncoGenex Pharmaceuticals (NASDAQ: OGXI ) announced today ... Thursday, August 6, 2009. OncoGenex will host a conference call ... discuss quarterly results. , The webcast can be accessed on ... www.oncogenex.com . Alternatively, you may access the live conference ...
... The years ... a big breakthrough in the search for a viable alternative feedstock for biodiesel in combination ... now happy to announce the much awaited commercial release of Couple oil crop cultivation (COC) ... (PRWEB) August 3, ...
... Aug. 2 Beckman Coulter, Inc. (NYSE: BEC ... simplify, automate and innovate complex biomedical testing, announced today the ... This acquisition, first announced in February, extends Beckman Coulter,s leadership ... (Logo: http://www.newscom.com/cgi-bin/prnh/20031202/BECLOGO ...
Cached Biology Technology:Jatropha Couple Oil Crop Cultivation Technology Commercially Released 2Jatropha Couple Oil Crop Cultivation Technology Commercially Released 3Beckman Coulter Completes Acquisition of Olympus' Lab-Based Diagnostics Business 2
(Date:10/14/2014)... been millions of years since T. rex ... Ohio University scientists is breathing life back into dinosaurs ... snouts. The research has important implications for how dinosaurs ... enhance the sense of smell and cool their brains. ... University doctoral student Jason Bourke, lead author of the ...
(Date:10/14/2014)... High doses of fish oil supplements, rich in omega-3 fatty ... irregular heartbeat in which the heart can beat as fast ... trial led by the Montreal Heart Institute were published in ... on October 7th. , For the trial, 337 patients with ... to 4 grams of fish oil a day or to ...
(Date:10/14/2014)... Pancreatic cancer likely takes between 10 and 20 ... very "broad window" of intervention if detected early, ... a predisposition, say Australian clinical researchers. , ... Sydney,s Garvan Institute of Medical Research, analysed medical ... of 766 pancreatic cancer patients, operated on between ...
Breaking Biology News(10 mins):Dinosaur breathing study shows that noses enhanced smelling and cooled brain 2Dinosaur breathing study shows that noses enhanced smelling and cooled brain 3Early detection window when pancreatic cancer is in the family 2
... Methodist University and The University of Texas at ... that shows promise in protecting brain cells against ... which afflict millions. Dallas-based startup EncephRx, Inc. ... owned compounds. A biotechnology and therapeutics company, EncephRx ...
... 2010 Polar research must become an integral part of ... from the dramatically changing face of the Polar Regions, the ... its strategic position paper on European polar research: "Relevance, Strategic ... activities in the Polar Regions are significant, amounting to over ...
... the emergency room after a fall. She has broken her ... screws or shiny titanium ball joints. Instead, she pulls out ... will solidify in seconds and injects into the break. Over ... natural growth factors embedded in the synthetic molecules of the ...
Cached Biology News:Novel compounds show early promise in treatment of Parkinson's, Huntington's, Alzheimer's 2Novel compounds show early promise in treatment of Parkinson's, Huntington's, Alzheimer's 3It's time for Europe to step up research in the polar regions 2In the lab, engineer's novel liquid provides a solid fix for broken bones 2
A collection of 42 spots with normal tissues from different organs of C57 mice, rat and human....
... The V-106 voice-coil scanning and positioning ... small samples have to be positioned ... high resolution. It provides superior responsiveness ... drives. The mechanics (X or XY ...
Improves spot morphology and DNA binding to the slide resulting in increased hybridization signal. ID Clarifier: Optimized spotting solution for use with SigmaScreen APS Coated Slides for Microarrays...
... General description: Humidity wells in the base ... chamber humidity and probe hydration around the ... eliminates the risk of waterbath contamination. This ... temperature waterbaths or hybridisation ovens. Linkage: This ...
Biology Products: