Navigation Links
Karyopharm Therapeutics announces the Publication of Two Preclinical Studies on the Activity of Selective Inhibitors of Nuclear Export (SINE) in Acute Myeloblastic Leukemia (AML)
Date:8/1/2012

NATICK, Mass., Aug. 1, 2012 /PRNewswire/ -- Karyopharm Therapeutics Inc., a leader in the new field of nuclear transport modulators, announced publication of preclinical models utilizing their proprietary SINE compounds in AML. SINEs specifically and irreversibly inhibit the nuclear transporter exportin 1 (XPO1), more commonly called CRM1 (chromosome region maintenance 1). CRM1 is the exclusive mediator of the nuclear export of p53, p73, pRb, FOXO, p21, p27, BRACA1, and other tumor suppressor proteins, along with the endogenous inhibitor of Nuclear Factor kB (NF-kB) known as IkB. Cancer cells use nuclear export of these key anti-tumor proteins to functionally inactivate them. Blockade of CRM1 with SINE leads to accumulation and activation of tumor suppressor and chemotherapy resistance proteins in the nucleus, leading to selective tumor cell apoptosis while sparing normal cells.

(Logo: http://photos.prnewswire.com/prnh/20120508/NE02031LOGO )

Romero Garzon, MD, PhD, and colleagues at the Ohio State University published a plenary paper in the journal Blood entitled, "Pre-clinical activity of a novel CRM1 inhibitor in acute myeloid leukemia" (PubMed ID: 22677130). The authors showed that Karyopharm's SINE compounds induced apoptosis at nanomolar levels in AML cell lines and in AML blasts from patients. SINEs reduced the levels of the AML oncoprotein FLT3, and when given orally to mice, prolonged their survival with good tolerability.

In the second paper, Tom Look, MD, and colleagues at the Dana Farber Cancer Institute in Boston published a paper in the journal Leukemia entitled "Anti-leukemic activity of nuclear export inhibitors that spare normal hematopoietic cells" (PubMed ID: 22847027). This paper describes the discovery of the SINE compounds based on the X-ray crystal structure of CRM1 using proprietary in silico screening methods developed by Karyopharm's fo
'/>"/>

SOURCE Karyopharm Therapeutics Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3

Related biology technology :

1. Karyopharm Therapeutics Announces Multiple Presentations on Selective Inhibitors of Nuclear Export (SINE) in Solid and Hematologic Malignancy Models and Spontaneous Canine Cancers at the American Association of Cancer Research (AACR) Meeting
2. Cell Therapeutics, Inc. (CTI) to Report Second Quarter Financial Results on August 1
3. United Therapeutics Corporation Reports Second Quarter 2012 Financial Results
4. Relmada Therapeutics Raises $3.0 Million In Initial Closing Of Series A Financing
5. United Therapeutics Corporation to Announce Second Quarter 2012 Financial Results Before Market Open on Thursday, July 26, 2012
6. Juventas Therapeutics Raises $22.2 Million Series B Financing
7. Silence Therapeutics Announces Subscription and Open Offer to Raise up to £5.7 Million
8. Nektar Therapeutics Announces Private Placement of $125 Million of Senior Secured Notes Due in 2017
9. Bio-Innovator Saneron CCEL Therapeutics Supports Cryo-Cell International Leadership and Board of Directors in Proxy Contest
10. Global Neuroendocrine Carcinoma Therapeutics Market To Reach $475m By 2019 - Report
11. United Therapeutics Announces Additional $100 Million Share Repurchase Program
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... 2014   Cypher Genomics, Inc., the ... Adam Simpson as president and chief ... comprehensive annotation and interpretation of individual human genomes ... "Cypher,s technology has the potential to play a ... accuracy, optimizing therapeutic approaches and reducing adverse drug ...
(Date:7/24/2014)... The patent provides substantially greater ... results. It also enables true sample ID and ... reporting of high profile assays such as those ... growing area of biotechnology that includes DNA based ... companion diagnostics in personalized medicine. The new patent ...
(Date:7/23/2014)... Ras Al Khaimah, United Arab Emirates (UAE) (PRWEB) July ... equity firm Grace Century recently announced that ... Dr. Jim Vaught , Ph.D. to its growing ... Century said, “We are very pleased to have Dr. ... along with the scientific depth and expertise that Provia’s ...
(Date:7/23/2014)... efforts have made great strides in saving China,s endangered ... are over 65 giant panda reserves that have been ... efforts, just 1596 pandas remain in the wild. ... to save the panda by improving genetic diversity, avoid ... Just how are these high-profile programs doing so far? ...
Breaking Biology Technology:Cypher Genomics Announces the Appointment of Adam Simpson as President and COO to Advance Transformative Genome Interpretation Technology 2Cypher Genomics Announces the Appointment of Adam Simpson as President and COO to Advance Transformative Genome Interpretation Technology 3New DNA-barcode Patent Virtually Eliminates False Test Results and Sample Mix-up 2Provia Laboratories Adds Dr. Jim Vaught, Ph.D., Former Chief of BBRB, to Advisory Board 2Provia Laboratories Adds Dr. Jim Vaught, Ph.D., Former Chief of BBRB, to Advisory Board 3Provia Laboratories Adds Dr. Jim Vaught, Ph.D., Former Chief of BBRB, to Advisory Board 4
... for some time that the hormone leptin acts in the ... remained a mystery. Now, new research published by Cell Press ... reveals neurobiological mechanisms that may underlie the antiobesity effects ... by fat cells and acts at its receptor in the ...
... clot-forming platelets every day, but there are times when ... diseases or during invasive surgery. Now, University of Pennsylvania ... bone marrow cells called megakaryocytes to quadruple the number ... student of pharmacology in Penn,s Perelman School of Medicine, ...
... carbon nanotubes, developed by MIT researchers, shows promise as an ... needed. Storing the sun,s heat in chemical form ... itself in a heavily insulated container has significant advantages, ... long periods of time without losing any of its stored ...
Cached Biology Technology:Modulation of inhibitory output is key function of antiobesity hormone 2Penn researchers show single drug and soft environment can increase platelet production 2Penn researchers show single drug and soft environment can increase platelet production 3MIT research update: New way to store sun's heat 2MIT research update: New way to store sun's heat 3
(Date:7/24/2014)... For years, researchers and patients have hoped that ... type in the bodycould provide insight into numerous diseases ... has been hampered by the inability to transfer research ... counterparts, in part because human ESCs are "primed" and ... Thorold Theunissen, Benjamin Powell, and Haoyi Wang, who are ...
(Date:7/24/2014)... conducting research into the potato genes that best adapt ... reduction in rainfall and increased extremes of hot and ... genes in order to create new potato varieties that ... also seeking to find out how the current potato ... and higher and lower temperatures. , This research is ...
(Date:7/24/2014)... of researchers led by the University of York has ... in the Western Indian Ocean. , The results, ... to a revolution in the management of marine protected ... than 11,000 km in the region now under ... zones of the seas and coasts designed to protect ...
Breaking Biology News(10 mins):Whitehead Institute researchers create 'naïve' pluripotent human embryonic stem cells 2Neiker-Tecnalia is researching the potato genes that best adapt to climate change 2Western Indian Ocean communities play vital role in conservation 2
... The last decade has seen a dramatic decline ... public health crisis across the world. A new ... patients a potential new approach toward the creation of ... become more resistant to our current classes of antibiotics, ...
... CLEVELAND Sediment in rivers comes from erosion of the ... banks themselves. Just how much each source contributes to a ... of that river is the subject of research by ... University. Taking measure of certain radionuclides found in the ...
... - When a reactor in the Chernobyl nuclear power ... Soviet republic of Ukraine, radioactive elements were released in ... and even eastern portions of North America. , ... Reserve University traveled to Sweden and Poland to gain ...
Cached Biology News:Groundbreaking discovery may lead to stronger antibiotics 2Case Western Reserve University project ties soil conservation and river management together 2Case Western Reserve University researchers track Chernobyl fallout 2
... The Varian 500-MS LC Ion ... for high-throughput LC/MS analysis where sensitivity, ... Varian 500-MS provides a robust platform ... sensitivity, mass resolution, and mass stability ...
... ejector is a unique product that facilitates ... their holder. Linkage: This CLS number is ... match Cornings product number. If showing no ... Sigma-Aldrich number (Z71,314-7) or contact customer service ...
Sigmas E-TOXATE (Limulus Amebocyte Lysate) test kits are intended for the detection and semiquantitation,of endotoxins for research purposes....
... These versatile enclosures ... with nitrogen or other ... a low-humidity environment. HEPA ... and ionization modules also ...
Biology Products: