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Karyopharm Therapeutics Closes $10 Million Series A2 Financing to Expand Planned Phase 1 Program of Oral Selective Inhibitors of Nuclear Export (SINE) for Cancer
Date:11/2/2011

l molecule modulators of nuclear transport.  The Company was founded by Drs. Sharon Shacham, Michael Kauffman, Giulio Draetta and Ronald DePinho in 2008.  Karyopharm completed a $20M Series A financing in October, 2010. The Company has won several grants/awards including a Biotech Investment Award by the Multiple Myeloma Research Foundation in 2010. Karyopharm's first program is directed towards the Selective Inhibition of Nuclear Export – its SINE program – targeting CRM1, the major nuclear export protein. By inhibiting the nuclear export of tumor suppressor proteins, Karyopharm's drug candidates force the activation of the cell's key tumor suppressor and anti-inflammatory pathways including p53, p21, pRB, FoxO, and the inhibitor of NF-kB (i.e., IkB).  Karyopharm anticipates entering the clinic in 2012 with its first oral SINE compound for the treatment of various cancers.  The Company is also evaluating the use of SINE in autoimmune, viral and dermatologic disorders.  Karyopharm Therapeutics is located in Natick, Massachusetts.

Contact: Michael Kauffman, +1-508-975-4821, mkauffman@karyopharm.com


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SOURCE Karyopharm Therapeutics Inc.
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