Navigation Links
Karyopharm Therapeutics Announces Multiple Presentations on Selective Inhibitors of Nuclear Export (SINE) in Solid and Hematologic Malignancy Models and Spontaneous Canine Cancers at the American Association of Cancer Research (AACR) Meeting
Date:3/7/2012

s and kill prostate cancer cells across multiple genotypes in vitro and in vivo" (Abstract 1841; Section 30). 

Drs. Asfar Azmi and Ramzi Mohammed of Wayne State University will present two posters: "CRM-1 as a potential therapeutic target in pancreatic cancer" (Abstract 1815; Section 30) and "Novel small molecule CRM-1 inhibitor for Non Hodgkin's Lymphoma" (Abstract 1825; Section 30).

Drs. Roberto Fragomeni and James Cusack of Massachusetts General Hospital will present "Potent anticancer activity against both BRAF-mutant and BRAF wild-type melanoma cell lines using a novel CRM1 nuclear export inhibitor" (Abstract 1914; Section 34).

Drs. Christopher Walker and Danilo Perrotti of the Ohio State University will present "Nuclear export (karyopherin) inhibitors: A novel therapeutic strategy for treating Philadelphia-positive (Ph+) acute leukemias" (Abstract 3839; Section 32).

Dr. Dilara McCauley of Karyopharm will present "Selective inhibitors of nuclear export (SINE) induce multiple tumor suppressor proteins (TSP) activity and show single agent antitumor effect and synergy with Bcl-2 antagonist in non-small cell lung cancer" (Abstract 1831; Section 30).

Dr. Yosef Landesman of Karyopharm will present a poster, "Pharmacokinetic (PK) / pharmacodynamic (PDn) and efficacy relationship of selective inhibitors of nuclear export (KPT-SINE)" (Abstract 3775; Section 30).

Karyopharm's founder and Chief Scientific Officer Dr. Sharon Shacham commented, "We are very pleased to share the results of our continuing collaborative and internal work on the mechanisms of action and anti-tumor activity of SINE compounds in the treatment of a variety of malignant conditions. We are encouraged by their activity in dogs with naturally occurring and chemotherapy refractory tumors, and we are on track to bring our first in class, oral clinical candidate into Phase 1 studies this year."

About Karyopharm

Karyopharm
'/>"/>

SOURCE Karyopharm Therapeutics Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3

Related biology technology :

1. Karyopharm Therapeutics Closes $10 Million Series A2 Financing to Expand Planned Phase 1 Program of Oral Selective Inhibitors of Nuclear Export (SINE) for Cancer
2. Incline Therapeutics to Present at the Cowen and Company 32nd Annual Health Care Conference
3. Foundation for Angelman Syndrome Therapeutics (FAST) Funds Human Clinical Trial
4. Silence Therapeutics Announces Board Changes and Appointment of New Chief Executive Officer
5. Orexigen Therapeutics to Present at Upcoming Conferences
6. ResearchMoz: Nanotech Enabled Drug Delivery Therapeutics Market Will be $136 Billion by the Year 2021: Nanotechnology in Drug Delivery: Global Markets
7. Oxford BioTherapeutics Appoints C. Glenn Begley as a Senior Clinical Advisor and Non-executive Director
8. Healthpoint Biotherapeutics to Present at 30th Annual J.P. Morgan Healthcare Conference
9. Nektar Therapeutics President and CEO, Howard W. Robin, to Present at the 30th Annual J.P. Morgan Healthcare Conference in San Francisco, CA
10. Halozyme Therapeutics to Present at the 30th Annual J.P. Morgan Healthcare Conference
11. Amsterdam Molecular Therapeutics Receives US Orphan Designation for Hemophilia B Gene Therapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... , July 31, 2014 Research and ... "Global Genomics Market 2014-2018" report to their offering. ... Genomics is the study of the genetic material or ... a strong basis for the discovery and development of ... diseases or health conditions. Genomics is supported by three ...
(Date:7/31/2014)... -- Senomyx , Inc. (NASDAQ: ... science technologies to discover, develop, and commercialize novel ... supply industries, today reported financial results for the ... quarter with $33.6 million in cash and highly ... quarter Senomyx achieved another important milestone with the ...
(Date:7/31/2014)... SAN DIEGO and SHENZHEN, China ... Genomics announced today the purchase of an ... genomics organization. BGI selected BioNano,s platform to enable comprehensive ... vastly improved assemblies for various organisms of interest, including ... BGI will partner together to develop new methods for ...
(Date:7/31/2014)... 2014 Rancho BioSciences , the ... Omicsoft’s Array Suite with tranSMART . Scientists ... to send data in tranSMART to Array Suite for ... of tranSMART including the new 1.2 release. Array ... storage for the analysis of high dimensional quantification data, ...
Breaking Biology Technology:Global Genomics Market 2014-2018: Key Vendors are F. Hoffmann-La Roche, Life Technologies, Qiagen and Illumina 2SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 2SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 3SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 4SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 5SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 6SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 7SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 8SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 9SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 10SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 11SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 12SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 13SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 14SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 15SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 16BioNano Genomics Announces the Purchase of the Irys System by BGI 2BioNano Genomics Announces the Purchase of the Irys System by BGI 3BioNano Genomics Announces the Purchase of the Irys System by BGI 4Rancho BioSciences, in Partnership with Omicsoft, have Integrated Array Suite with tranSMART 2Rancho BioSciences, in Partnership with Omicsoft, have Integrated Array Suite with tranSMART 3
... DALLAS, May 7 Entrust, Inc. (Nasdaq: ENTU ... the 8th Annual,State of Technology Luncheon on Thursday, May ... Dallas, Texas., Conner will address the history of ... evolved to address the growing threats.,Conner also will discuss ...
... today announced,the first single port laparoscopic removal of ... Anthony Discuillo and Christopher Awtry performed the procedure ... System creates an,invisible barrier that does not rely ... the cavity without loosing intra-abdominal pressure,enabling surgeons to ...
... leading contract research,organization Pharm-Olam International (POI, http://www.pharm-olam.com ),upgraded ... (VoIP),system that would better serve the company,s global communications ... initially selected a local vendor to plan, develop and ... solution was a bigger problem,than the old PBX., ...
Cached Biology Technology:Entrust Chairman, President and CEO Bill Conner to Present at 8th Annual State of Technology Luncheon 2SurgiQuest Announces First Single Port Procedure for Ovary Removal Using AirSeal(TM) Access System 2Pharm-Olam Finds VoIP Solution in Taridium LLC 2
(Date:8/1/2014)... fossil record about 200,000 years ago, but it was ... advanced tools became widespread. , A new study ... finds that human skulls changed in ways that ... same time that culture was blossoming. , "The modern ... cultural exchange probably came at the same time that ...
(Date:8/1/2014)... Scientists examining a taxonomically confused group of marine ... science: the Australian humpback dolphin, Sousa sahulensis ... Clymene Enterprises. , The study describing the ... 17-year long systematic examination of all available historical ... dolphinsa widespread group of coastal cetaceans ranging from ...
(Date:8/1/2014)... component of phloem, the conductive tissue through which plants ... Elongated cylindrical cells are capped at one end by ... tubes which in turn form a network throughout a ... special cells which play an important role in carbon ... about their differentiation," says Professor Yk Helariutta from the ...
Breaking Biology News(10 mins):Society bloomed with gentler personalities and more feminine faces 2Scientists name new species of cetacean: The Australian humpback dolphin 2Scientists name new species of cetacean: The Australian humpback dolphin 3Developmental regulation of important plant phloem components discovered 2
... MDThe Endocrine Society today issued a Clinical Practice Guideline ... syndrome, the most common hormone disorder in women of ... The CPG, entitled "Diagnosis and Treatment of Polycystic Ovary ... in the December 2013 issue of the Journal ...
... get a major boost from a 35 million nationwide initiative ... cancer research. Cancer Research UK and the Engineering and ... for five years to four separate cancer imaging centres across ... world leader in cancer imaging research. The new initiative builds ...
... The Johns Hopkins University will collaborate with Belgian ... in health care, beginning with development of a ... clinical tests to be performed outside the laboratory. ... Hopkins clinical and research expertise with imec,s technical ...
Cached Biology News:Experts clarify conflicting criteria for diagnosing polycystic ovary syndrome 2Cancer imaging centers get £35 million boost 2Cancer imaging centers get £35 million boost 3Johns Hopkins And Belgian research center to expand health care applications for silicon nanotech 2
... The Vibratome Company has joined forces ... introduce the Vibratome 800 Tissue Chopper. This ... prepare sections of tissue for metabolic experiments ... and irregular specimens available at biopsy or ...
... a new product number, created to ... showing no availability yet, please order ... or contact customer service for assistance. ... easy grip) Mfr Desig: ...
... is a fluorescence scanner with 1 or ... Packing, Protein, CGH, ) spotted on standard ... of InnoScan700 scanners include three different models:, ... a simultaneous dual fluorescence scanner (635nm and ...
... is a new product number, ... product number. If showing no ... the old Sigma-Aldrich number (R4026) ... assistance. Material: cap polystyrene ...
Biology Products: