Navigation Links
K-State Research Team Investigates Mutated Gene's Role in Breast Cancer

MANHATTAN, Kan., Aug. 13 /PRNewswire-USNewswire/ -- A microscopic gene may play a gigantic role when it comes to cancerous tissue in the human body, according to one Kansas State University research team.

The team is investigating mutation within the ADAM12 gene of the A Disintegrin and Metalloprotease family, or ADAM family, and its role in breast cancer.

"We want to know whether ADAM12 is a good guy or a bad guy in breast cancer," said Anna Zolkiewska, associate professor of biochemistry and research team leader.

If researchers can answer this question about ADAM12, Zolkiewska said it could lead to more effective therapies and treatments due to a better understanding of cancer's components. This, however, hinges on discovering the exact nature of ADAM12, about which little is known. Research has uncovered some interesting information -- and raised more questions, Zolkiewska said.

"Typically human cells have very little ADAM12 protein, but the abundance is suddenly very high in cancer tissue," she said. "When we look even closer, we find a very high level of ADAM12 expression in what we call cancer stem cells. Those cells are the most vicious as they drive the tumor growth."

Although chemotherapy and radiotherapy kill tumors, they are ineffective on the cancer stem cells, Zolkiewska said. Without being surgically removed from the body, the stem cells will grow another tumor over the course of a few years. This again raises the question as to the role of ADAM12.

"Is it helping that tumor re-grow or is it trying to prevent it?" Zolkiewska asks.

Perhaps the most perplexing question the team hopes to solve is why the ADAM12 gene mutates inside cancer tissue.

"Mutation means that one letter in the DNA within the cell has changed," Zolkiewska said. "This is very striking because there are only a handful of human genes that are changed that way in tumors. ADAM12 is one of those genes and the only one among that family."

Zolkiewska said this raises the questions of whether the gene's mutation in cancer tissue is purely a coincidence or is part of a larger role. Prior research by the team indicates ADAM12 is a "good guy" since mutation to the gene effectively kills ADAM12 protein.

"A tumor wants to grow, and from the point of view of the tumor, you want to invade and kill the patient. So you will first take care of those good guys, or those policemen inside the body who protect the patient," Zolkiewska said. "If ADAM12 is one of those good guys, the growing tumor wants to take it out of the picture."

This discovery of mutation rendering ADAM12 dead was a scientific first by the K-State team.

Zolkiewska recently was awarded a three-year grant of $444,000 from the National Institutes of Health to further the research. The grant's title is "Structure-Function Analysis of Breast Cancer-Associated Mutations in ADAM12."

Assisting Zolkiewska in the research are Sara Duhachek Muggy, Manhattan, a graduate student in biochemistry, and Hui Li, who is conducting postdoctoral work. Zolkiewska credited a large portion of the team's findings to Emilia Solomon, Los Alamos, N.M., a December 2009 biochemistry doctoral graduate.

SOURCE Kansas State University
Copyright©2010 PR Newswire.
All rights reserved

Related biology technology :

1. K-States Biosecurity Research Institute Gives Researchers the Tools Needed to Study Diseases That Cost Pig Producers Hundreds of Millions of Dollars Each Year
2. Connecting Materials Science With Biology, K-State Engineers Create DNA Sensors That Could Identify Cancer Using Material Only One Atom Thick
3. Researchers successfully test new alternative to traditional semiconductors
4. WSU researchers use super-high pressures to create super battery
5. Pitt-led researchers to build foundation for quantum supercomputers with $7.5 million federal grant
6. Octapharma Grants Program Awards First Research Grant to Rush University Medical Center
7. Engineering researchers simplify process to make worlds tiniest wires
8. NSF funds infection-resistant orthopedic research
9. CSHL researchers demonstrate efficacy of antisense therapy for spinal muscular atrophy
10. University of Toronto chemists make breakthrough in nanoscience research
11. NeoStem to Receive $700,000 from the U.S. Armys Medical Research and Materiel Command to Advance Adult Stem Cell Therapies in Treating Traumatic Wounds
Post Your Comments:
(Date:11/24/2015)... 2015 /PRNewswire/ - Aeterna Zentaris Inc. (NASDAQ:  AEZS) (TSX: AEZ) ... of the Toronto Stock Exchange, confirms that as of ... corporate developments that would cause the recent movements in ... --> About Aeterna Zentaris Inc. ... Aeterna Zentaris is a specialty biopharmaceutical company engaged ...
(Date:11/24/2015)... PUNE, India , November 24, 2015 ... to a new market research report "Oligonucleotide Synthesis Market ... Equipment), Application (PCR, Gene Synthesis, Diagnostic, DNA, RNAi), End-User ... to 2020", published by MarketsandMarkets, the market is expected ... 1,078.1 Million in 2015, at a CAGR of 10.1% ...
(Date:11/24/2015)... ... 2015 , ... The Academy of Model Aeronautics (AMA), led by its Executive ... Multirotor Grand Prix, to represent the First–Person View (FPV) racing community. , FPV racing ... this type of racing and several new model aviation pilots have joined the community ...
(Date:11/24/2015)... ALBANY, New York , November 24, 2015 /PRNewswire/ ... According to a recent market research report released by ... is projected to expand at a CAGR of 17.5% ... titled "Non-invasive Prenatal Testing Market - Global Industry Analysis, ... 2022", estimates the global non-invasive prenatal testing market to ...
Breaking Biology Technology:
(Date:11/9/2015)... , Nov. 09, 2015 ... addition of the "Global Law Enforcement ... offering. --> ) has ... Law Enforcement Biometrics Market 2015-2019" report ... and Markets ( ) has announced ...
(Date:10/29/2015)... 2015  The J. Craig Venter Institute (JCVI) policy ... and Biosecurity: Lessons Learned and Options for the Future," ... Human Services guidance for synthetic biology providers has worked ... --> --> Synthetic biology promises ... to pose unique biosecurity threats. It now is easier ...
(Date:10/29/2015)... YORK , Oct. 29, 2015 ... technology, announced a partnership with 2XU, a global ... to deliver a smart hat with advanced bio-sensing ... and other athletes to monitor key biometrics to ... the strategic partnership, the two companies will bring together ...
Breaking Biology News(10 mins):