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Juventas Therapeutics Initiating Phase II Clinical Trial of JVS-100 for Treatment of Critical Limb Ischemia
Date:1/3/2011

chool of Medicine.  "Novel regenerative therapies, such as JVS-100, have the potential to restore blood flow and improve outcomes for these patients."

There are approximately 3 million U.S. citizens with critical limb ischemia.  The hospital treatment costs for these patients exceed $10 billion with average in-patient charges surpassing those for stroke or heart attack.  Within a year of CLI diagnosis, up to 50% of patients will undergo an amputation and 25% will die.

The Juventas therapeutic platform is based on discoveries made nearly a decade ago by Marc Penn, M.D., Ph.D., Director of the Bakken Heart-Brain Institute at the Cleveland Clinic and Juventas' Chief Medical Officer.  Dr. Penn demonstrated that SDF-1 is a strong chemo-attractant for hematopoietic stem cells (HSCs), with the potential to promote cardiac repair when delivered to the heart hours to months following a heart attack.  These findings were published in 2003 in The Lancet and have now been validated by several independent laboratories.  The SDF-1 repair pathway is conserved in most end organ systems, including the heart, peripheral vasculature, kidney, skin, liver and eye.

"Our work on SDF-1 originates from the hypothesis that we all have a natural stem cell based repair process that attempts to repair organs following injury," states Dr. Penn.  "We believed that if we could identify the molecular factors that activate this pathway, they could be delivered at a time post-injury to promote tissue preservation.  SDF-1 has proven to be a key player in driving repair and we are excited to see our findings translating to the clinic with the potential to help patients".

About Juventas Therapeutics

Juventas Therapeutics, headquartered in Cleveland, OH, is a privately-held clinical-stage biotechnology company developing a pipeline of regenerative therapies to treat life–threatening diseases. Founded in 2007
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SOURCE Juventas Therapeutics, Inc.
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