Navigation Links
Journal of Clinical Investigation Publishes Data Demonstrating Enhanced Antitumor Efficacy of Second Generation DeCIDe™ Technology
Date:3/8/2011

HOUSTON, March 8, 2011 /PRNewswire/ -- Bellicum Pharmaceuticals, Inc. today announced the publication of studies comparing AP1903-activated iMyD88/CD40-transduced dendritic cells (DCs) to conventionally matured DCs, in the April 2011 issue of The Journal of Clinical Investigation (JCI).  The studies, conducted by researchers at Baylor College of Medicine, explored the feasibility of a second generation DeCIDe™ vector that combines an inducible toll like receptor (TLR) adapter molecule, iMyD88, with the first generation's inducible CD40 receptor, iCD40.

In the JCI publication, published online on March 7, Narayanan et al reported that chemically induced dimerization (CID) of iMyD88 can replace exogenous, pro-inflammatory adjuvants, providing the danger signal necessary for full DC activation.  Moreover, the manuscript shows for the first time that CD40 and MyD88 signaling domains may be fused into the same iMyD88/CD40 chimeric CID protein, which when activated by AP1903 leads to:  

  • Synergistic activation of downstream signaling molecules in primary DCs.
  • Elaboration of high, therapeutic levels of the T helper 1 (Th1) polarizing cytokine, IL-12, leading to the efficient expansion of CD8+ cytotoxic T lymphocytes (CTLs) in vivo.
  • Full activation of DCs within lymph nodes, the physiologically appropriate site for activation.
  • Elimination of a variety of pre-established tumors in mice, including aggressive B16 melanoma.

"By incorporating TLR signaling into the DeCIDe™ vector, we avoid the need for exogenous TLR adjuvants, while also achieving more potent antitumor activity," stated corresponding author Dr. David Spencer, Vice Chairman of the Department of Pathology and Immunology at Baylor College of Medicine, and Bellicum's Chief Scientific Officer.

Bellicum is working to incorporate this second generation technology into future DeCID
'/>"/>

SOURCE Bellicum Pharmaceuticals, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2

Related biology technology :

1. DOE JGI Director Eddy Rubin highlights the genomics of plant-based biofuels in the journal Nature
2. Preliminary Report of American Biotech Labs HIV Study Featured in Inaugural Issue of Journal of the Science of Healing Outcomes
3. Epeius Biotechnologies Lead Product, Rexin-G for Metastatic Cancer, Aptly Highlighted by National Cancer Institute Journal
4. Sigma-Aldrich(R) Becomes First Life Science Company to Publish in PubMeds Peer-Reviewed Video Journal JoVE
5. Sigma-Aldrich(R) Becomes First Life Science Company to Publish in Peer-Reviewed Video Journal JoVE
6. Tips from the journals of the American Society for Microbiology
7. Althea Technologies Receives Fast Growth Honors: Deloitte Technology Fast 50 and San Diego Business Journal Fast 100 Awards for the Fifth Consecutive Year
8. PAREXEL Corporate Vice President Dr. Alberto Grignolo Receives Lifetime Achievement Award From Good Clinical Practice Journal
9. Publication on Tregitopes in Blood Journal of October 2008
10. The Lancets New Online Medical Journal Helps Clinicians and Medical Researchers Find Practice-Changing Evidence Quickly and Easily
11. PAREXEL Partners with Glenmark to Win the Good Clinical Practice Journal Award for Most Innovative Patient Recruitment Strategy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2014)... Opertech Bio, Inc., a company ... effective approach to sensory evaluation, today announced the ... U.S. Patent and Trademark Office, encompassing high-throughput sensory ... “Opertech’s taste evaluation technology called Microtiter Operant Gustometer ... system for rapid characterization of taste sensory properties,” ...
(Date:9/2/2014)... Inc. (TSXV: BRM) ("Biorem" or "the Company") today announced three ... large odour control systems for waste water treatment plants in ... consistent with the market resurgence in North America ... "After a difficult period of restraint in our core municipal ... growth. Our lower cost structure, technology improvements and supply chain ...
(Date:9/1/2014)... 2014 Reportlinker.com announces that a new ... India Solid Waste Management Vehicles Market ... http://www.reportlinker.com/p02350445/India-Solid-Waste-Management-Vehicles-Market-Forecast-and-Opportunities-2019.html In India ... bodies responsible for complete handling and regulation of ... around 135,000 MT solid waste is generated daily ...
(Date:8/31/2014)... (PRWEB) August 31, 2014 ... Industry” is a professional and in-depth research ... provides basic Polyacrylamide information, including Polyacrylamide definition, ... well as industry overview. This research covers ... as well as global industry analysis covering ...
Breaking Biology Technology:Opertech Bio Receives U.S. Patent for High-Throughput Taste Evaluation Technology 2India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 2India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 3India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 4India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 5India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 6India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 7India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 8International Polyacrylamide Industry & Copper Iodide Market Data Analysis Now Available at DeepResearchReports.com 2International Polyacrylamide Industry & Copper Iodide Market Data Analysis Now Available at DeepResearchReports.com 3
... In the quest to exploit unique properties at ... have developed a novel technique for creating uniform ... and students in the Department of Physics and ... methods from holographic lithography to demonstrate a new ...
... Pharmaceuticals, Inc. (NASDAQ: IDIX ), announced today that ... Stanley Global Healthcare Conference on September 13 at 8:35 a.m. ... the Bank of America Merrill Lynch Global Healthcare Conference on ... of America Merrill Lynch Financial Centre, London.   ...
... Cellectis (Alternext: ALCLS), the French genome engineering specialist, will present at ... September 20, 2011, and at the MidCap Event in Paris on ... will present the activities and the development strategy of the Cellectis ... Hyatt New York hotel on Tuesday, September 20, 2011 at 11:30 ...
Cached Biology Technology:Stevens researchers pioneer novel technique to make plasmonic nanogap arrays 2Stevens researchers pioneer novel technique to make plasmonic nanogap arrays 3
(Date:9/2/2014)... Field Museum will present the prestigious Parker/Gentry Award to ... to biodiversity conservation awareness. The Parker/Gentry Award is given ... team or organization whose efforts have had a significant ... whose actions can serve as a model to others. ... environmental science and conservation news website that draws more ...
(Date:9/2/2014)... of Human Genetics (ASHG) and the National Human ... Institutes of Health, have named Elizabeth P. Tuck, ... School in Columbus, Ohio, the first ASHG/NHGRI Genetics ... , The Genetics and Education Fellowship is intended ... experience, and network to prepare for a career ...
(Date:9/2/2014)... It,s not always true that digital distribution of ... by physical means, at least when file sizes ... study published in Yale,s Journal of Industrial ... of games for consoles such as PlayStation3. Researchers ... caused lower greenhouse gas emissions than game files ...
Breaking Biology News(10 mins):ASHG and NHGRI award first genetics and education fellowship 2
... The work of molecular biologist Joseph M. Miano, ... Miano helps head the Aab Cardiovascular Research Institute and ... and Pediatrics program at the University of Rochester Medical ... was highly unlikely, shared enthusiasm, intense curiosity and a ...
... of researchers from the University of Valladolid (Spain) has analysed ... free iron than pale and non-alcoholic beers. Iron is essential ... compounds that give these beverages stability and flavour. According ... (UVa) on 40 types of beers from all 5 continents, ...
... Scientists at the National Physical Laboratory (NPL) have mimicked ... genetic material. The research hopes to apply the approach ... defective genes such as those that cause cancer. ... challenges around targeting damaged cells and creating corrective genes. ...
Cached Biology News:In quest for new therapies, clinician-scientist team unlocks hidden information in human genome 2In quest for new therapies, clinician-scientist team unlocks hidden information in human genome 3In quest for new therapies, clinician-scientist team unlocks hidden information in human genome 4Dark beer has more iron than pale beer 2
... Agarose overlays are commonly used ... commercial "DNA grade" agaroses either ... to insect cells or lack ... obtain good overlays. Novagen's BacPlaque ...
AgarPlaque Plus Agarose 50 grams...
...
...
Biology Products: