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Journal of Clinical Investigation Publishes Data Demonstrating Enhanced Antitumor Efficacy of Second Generation DeCIDe™ Technology
Date:3/8/2011

HOUSTON, March 8, 2011 /PRNewswire/ -- Bellicum Pharmaceuticals, Inc. today announced the publication of studies comparing AP1903-activated iMyD88/CD40-transduced dendritic cells (DCs) to conventionally matured DCs, in the April 2011 issue of The Journal of Clinical Investigation (JCI).  The studies, conducted by researchers at Baylor College of Medicine, explored the feasibility of a second generation DeCIDe™ vector that combines an inducible toll like receptor (TLR) adapter molecule, iMyD88, with the first generation's inducible CD40 receptor, iCD40.

In the JCI publication, published online on March 7, Narayanan et al reported that chemically induced dimerization (CID) of iMyD88 can replace exogenous, pro-inflammatory adjuvants, providing the danger signal necessary for full DC activation.  Moreover, the manuscript shows for the first time that CD40 and MyD88 signaling domains may be fused into the same iMyD88/CD40 chimeric CID protein, which when activated by AP1903 leads to:  

  • Synergistic activation of downstream signaling molecules in primary DCs.
  • Elaboration of high, therapeutic levels of the T helper 1 (Th1) polarizing cytokine, IL-12, leading to the efficient expansion of CD8+ cytotoxic T lymphocytes (CTLs) in vivo.
  • Full activation of DCs within lymph nodes, the physiologically appropriate site for activation.
  • Elimination of a variety of pre-established tumors in mice, including aggressive B16 melanoma.

"By incorporating TLR signaling into the DeCIDe™ vector, we avoid the need for exogenous TLR adjuvants, while also achieving more potent antitumor activity," stated corresponding author Dr. David Spencer, Vice Chairman of the Department of Pathology and Immunology at Baylor College of Medicine, and Bellicum's Chief Scientific Officer.

Bellicum is working to incorporate this second generation technology into future DeCID
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SOURCE Bellicum Pharmaceuticals, Inc.
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