Navigation Links
JCI table of contents: Dec. 3, 2007
Date:12/3/2007

2504

ACCOMPANYING COMMENTARY
TITLE: The weight of cell identity

AUTHOR CONTACT:
David T. Scadden
Massachusetts General Hospital Center for Regenerative Medicine, Boston, Massachusetts, USA.
Phone: (617) 726-5615; Fax: (617) 726-4691; E-mail: scadden.david@mgh.harvard.edu.

View the PDF of this article at: https://www.the-jci.org/article.php?id=34181


NEUROBIOLOGY: You snooze, you dont lose: Cellular repercussions of sleep deprivation

Sleep loss can be both beneficial (as an antidepressive) and detrimental (as it can cause cognitive impairment). Hypocretin/orexin neurons are brain cells that support wakefulness, but how they might contribute to the prolonged wakefulness that occurs upon sleep deprivation is not clear. However, in a new study, Xiao-Bing Gao and colleagues at Yale University School of Medicine, New Haven, have identified changes involving these neurons that occur in the brain of mice during prolonged sleep loss.

Communication between neurons occurs across synapses, the junctions between these cells. When the communication across a synapse is enhanced for a long time, it is called long-term potentiation. Following an imposed sleep deprivation (induced either by a drug or continual gentle handling) of 24 hours in mice, long-term potentiation of the synapses between hypocretin/orexin neurons was detected. The authors therefore suggested that these changes might be responsible for the effects of sleep deprivation. Indeed, in an accompanying commentary, Chiara Cirelli and Giulio Tononi from the University of Wisconsin, Madison, suggest that This increase in [long-term potentiation of the synapses between hypocretin/orexin neurons] may be one of the mechanisms that help us to stay awake when we are sleep deprived, but it may also represent one of the si
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8 9 10 11 12 13

Related biology technology :

1. Ranexa(R) Added to New ACC/AHA Guidelines on Unstable Angina/Non ST-Elevation Myocardial Infarction (UA/NSTEMI)
2. AUDIO from Medialink and GlaxoSmithKline: Fiber Key in Managing Irritable Bowel Syndrome (IBS) Symptoms
3. Lexicon Presents Class of Compounds Modulating TPH1, the Target for its LX1031 Investigational Drug for Irritable Bowel Syndrome
4. FDA Accepts Sucampos sNDA for Lubiprostone (8 mcg) for the Treatment of Irritable Bowel Syndrome with Constipation (IBS-C)
5. Sheet of carbon atoms acts like a billiard table, physicists find
6. Sheet of carbon atoms acts like a billiard table, physicists find
7. New Phase III Data Demonstrate Oxycodone / Naloxone Combination Tablet Reduces Opioid-Induced Bowel Dysfunction in Patients With Chronic Severe Pain
8. Caraco Pharmaceutical Laboratories, Ltd. Announces FDA Approval to Market Methimazole Tablets USP, 5 mg and 10 mg
9. Dey L.P. and Critical Therapeutics Launch Twice-Daily ZYFLO CR(TM) (Zileuton) Extended-Release Tablets for the Chronic Treatment of Asthma
10. FDA Approves New 300mg Loading Dose Tablet for PLAVIX(R) (clopidogrel bisulfate)
11. CV Therapeutics Submits Supplemental New Drug Application for Ranexa(R) (ranolazine extended-release tablets)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/27/2015)... Balaton, MN (PRWEB) April 27, 2015 ... into an agreement with Texas A&M University for the ... referred to as super-intensive raceway systems. The license agreement ... Dr. Addison Lawrence, extends to countries such as China, ... United Kingdom. , “We have had inquires from ...
(Date:4/27/2015)... Diasome Pharmaceuticals, Inc. (“Diasome”) has announced ... Center (“Joslin”) to collaborate on the design of ... Directed Vesicle (“HDV”) targeting system for insulin in ... in Boston, Massachusetts, Joslin is the world's leading ... to the prevention, treatment and cure of diabetes. ...
(Date:4/27/2015)... -- Together with its customers, Elekta raised EUR 30,575 (USD ... Barcelona . The funds will be donated to ... improve cancer care, specifically radiation oncology care, around the ... should be denied potentially life-saving treatment simply because the ... and clinics around the world to take care of ...
(Date:4/27/2015)... 2015 Elsevier , a world-leading ... and Qatar University Research Office   have announced the winners ... The awards ceremony, held last week at Qatar ... by more than 40 guests representing Qatar,s ... Professor Sheikha Abdulla Al-Misnad , President of ...
Breaking Biology Technology:tru Shrimp™ Systems Acquires Global Patent for Tidal Basin™ Shrimp Production 2Diasome Pharmaceuticals Announces Clinical Trial Design Collaboration 2Elekta helps raise $33,000 to bring radiation treatment to developing countries 2Elekta helps raise $33,000 to bring radiation treatment to developing countries 3Elsevier Announces the Winners of Qatar University Scientists 2015 Scopus Awards 2Elsevier Announces the Winners of Qatar University Scientists 2015 Scopus Awards 3Elsevier Announces the Winners of Qatar University Scientists 2015 Scopus Awards 4Elsevier Announces the Winners of Qatar University Scientists 2015 Scopus Awards 5
... Nov. 29 As part of an ongoing ... maximize commercial,impact of their products, Premier Research Group ... industry-leading expertise in its core,service areas into a ... expertise within the group closely matches Premier Research,s ...
... Multi-stakeholder initiative will use health information technology ... safety efforts across,the U.S., WASHINGTON, Nov. ... announced today the formation of an innovative,research ... patients. The eHI,Connecting Communities for Drug Safety ...
... Prometheus Laboratories Inc., a,specialty pharmaceutical company ... exclusive license agreement to develop and commercialize ... North America from,Alizyme Therapeutics Limited, a wholly ... unique competitive profile based on Alizyme,s proprietary,COLAL(R) ...
Cached Biology Technology:Product Development Timelines and Commercialization Strategy Are Focus of New Group at Premier Research 2eHealth Initiative Foundation Launches Collaborative Research Effort to Improve Drug Safety 2eHealth Initiative Foundation Launches Collaborative Research Effort to Improve Drug Safety 3eHealth Initiative Foundation Launches Collaborative Research Effort to Improve Drug Safety 4eHealth Initiative Foundation Launches Collaborative Research Effort to Improve Drug Safety 5eHealth Initiative Foundation Launches Collaborative Research Effort to Improve Drug Safety 6Prometheus Licenses COLAL-PRED(R) From Alizyme 2Prometheus Licenses COLAL-PRED(R) From Alizyme 3Prometheus Licenses COLAL-PRED(R) From Alizyme 4
(Date:3/20/2015)... 20, 2015 Research and Markets ... the "India Sensors Market Forecast and Opportunities ... The sensor market is projected to grow at ... Consumer electronics, automotive, industrial and healthcare sectors are ... country. In addition, adoption of MEMS technology in ...
(Date:3/20/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/vkzvcs/iris_biometrics ) has announced ... Business Report" report to their offering. This ... Thousands. The report provides separate comprehensive analytics for the US, ... Europe , Asia-Pacific , ... America . Annual estimates and forecasts are ...
(Date:3/17/2015)... 2015 MedNet Solutions , a ... study management systems, is pleased to announce that ... Outsourcing in Clinical Trials Southeast conference – March ... excellent forum for MedNet to showcase iMedNet ... (SaaS) eClinical technology platform. We strongly ...
Breaking Biology News(10 mins):India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 2India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 3Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 2Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 3Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 4Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 5Connect With MedNet Solutions At Outsourcing In Clinical Trials Southeast 2
... of Toronto and the Swiss Federal Institute of Technology ... exotic plants will likely eliminate native plants growing in ... A study published in Proceedings of the National ... that invasive plants are not problematic are often based ...
... January 2013) The microbial communities that reside in the ... are an expanding area of research full of exciting discoveries ... on the most recent advances in the field, scientists and ... For Health World Summit, which is hosted this year by ...
... changed diabetes from a death sentence to a chronic ... Case Western Reserve University School of Medicine announced a ... lives of people managing diabetes. After decades of ... international group of scientists finally found a definitive answer: ...
Cached Biology News:Invading species can extinguish native plants despite recent reports 2After decades of research, scientists unlock how insulin interacts with cells 2After decades of research, scientists unlock how insulin interacts with cells 3
IgD Chain C (AMS 9.1)...
Bethyl Laboratories packages antibodies, conjugates and calibrators to provide quantitative ELISA kits. Each kit contains the following components, sufficient for 1000 single well assays....
Applications: Epitope mapping, Mapping protein-protein contacts, Identification of enzyme substrates/inhibitors, Identification of receptor agonists/antagonists...
Bethyl Laboratories packages antibodies, conjugates and calibrators to provide quantitative ELISA kits. Each kit contains the following components, sufficient for 1000 single well assays....
Biology Products: