Navigation Links
JCI table of contents: Dec. 3, 2007
Date:12/3/2007

the origin of the fat cell

A recent study in the Journal of Clinical Investigation indicated that in mice, under certain circumstances (either a high-fat diet or treatment with the antidiabetic drug rosiglitazone), cells derived from the bone marrow known as BMDCPCs can act as precursors of fat cells (adipocytes). However, a new study in mice by Gou Young Koh and colleagues at the Korea Advanced Institute of Science and Technology, Republic of Korea, suggests that this is not the case. The potential reasons for these distinct observations, as well as the impact of the observation that BMDCPCs cannot become adipocytes in vivo, are discussed in an accompanying commentary by David Scadden from Massachusetts General Hospital Center for Regenerative Medicine, Boston.

In the study, mouse bone marrow cells expressing a fluorescent marker were transplanted into normal mice and the fat tissue of the recipient mice was analyzed for the presence or absence of marked cells 2 months later. No marked adipocytes were detected, even in mice fed a high-fat diet and in mice treated with rosiglitazone. Although marked cells that looked similar to adipocytes were observed in the fat tissues, further analysis indicated that these cells expressed no proteins characteristic of adipocytes. Instead, the marked cells expressed proteins characteristic of cells known as macrophages. The authors therefore concluded that BMDCPCs do not become adipocytes in vivo.

TITLE: Bone marrowderived circulating progenitor cells fail to transdifferentiate into adipocytes in adult adipose tissues in mice

AUTHOR CONTACT:
Gou Young Koh
Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.
Phone: 82-42-869-2638; Fax 82-42-869-2610; E-mail: gykoh@kaist.ac.kr.

View the PDF of this article at: https://www.the-jci.org/article.php?id=3
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8 9 10 11 12 13

Related biology technology :

1. Ranexa(R) Added to New ACC/AHA Guidelines on Unstable Angina/Non ST-Elevation Myocardial Infarction (UA/NSTEMI)
2. AUDIO from Medialink and GlaxoSmithKline: Fiber Key in Managing Irritable Bowel Syndrome (IBS) Symptoms
3. Lexicon Presents Class of Compounds Modulating TPH1, the Target for its LX1031 Investigational Drug for Irritable Bowel Syndrome
4. FDA Accepts Sucampos sNDA for Lubiprostone (8 mcg) for the Treatment of Irritable Bowel Syndrome with Constipation (IBS-C)
5. Sheet of carbon atoms acts like a billiard table, physicists find
6. Sheet of carbon atoms acts like a billiard table, physicists find
7. New Phase III Data Demonstrate Oxycodone / Naloxone Combination Tablet Reduces Opioid-Induced Bowel Dysfunction in Patients With Chronic Severe Pain
8. Caraco Pharmaceutical Laboratories, Ltd. Announces FDA Approval to Market Methimazole Tablets USP, 5 mg and 10 mg
9. Dey L.P. and Critical Therapeutics Launch Twice-Daily ZYFLO CR(TM) (Zileuton) Extended-Release Tablets for the Chronic Treatment of Asthma
10. FDA Approves New 300mg Loading Dose Tablet for PLAVIX(R) (clopidogrel bisulfate)
11. CV Therapeutics Submits Supplemental New Drug Application for Ranexa(R) (ranolazine extended-release tablets)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)...   ISN has released its third annual ... publication series. With data aggregated from over eight ... within its online contractor management platform, ISNetworld, this three-part ... (KPI) statistics. The Contractor ... is available in two industry specific volumes: Oil ...
(Date:12/17/2014)... Washington, USA (PRWEB) December 16, 2014 ... Baum, manager at Philipps- Universität Marburg’s Department of ... and photonics, in the newly released SPIE ... “And never be too shy to ask questions.” ... (science, technology, engineering, and mathematics) occupations ranging from ...
(Date:12/17/2014)... 17, 2014 This report is ... Tubing industry. For an overview analysis, the report ... industry chain structure, industry overview, policy analysis, and ... industry has witnessed rapid development with key ... acquisitions. This report mentions quartz tubing upstream raw ...
(Date:12/17/2014)... , Dec. 16, 2014  Vermillion, Inc. (NASDAQ: ... on gynecologic disease, today announced the next step in ... premier bio-analytics solutions provider with the naming of current ... and Chief Executive Officer, while current Chairman of the ... to serve as Chairman. These changes are effective January ...
Breaking Biology Technology:ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 2ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 3Network, Multitask, Persevere: SPIE Women in Optics Planner Subjects Share from Experience 2Network, Multitask, Persevere: SPIE Women in Optics Planner Subjects Share from Experience 32020 Quartz Tubing Market: Global Development & Forecasts Analysis Now at DeepResearchReports.com 2Vermillion Names Valerie Palmieri CEO; James LaFrance to continue as Chairman of Board 2Vermillion Names Valerie Palmieri CEO; James LaFrance to continue as Chairman of Board 3Vermillion Names Valerie Palmieri CEO; James LaFrance to continue as Chairman of Board 4
... MUNDELEIN, Ill., June 2 Medline Industries, Inc., ... medical,supplies, announced today that it has signed a ... a manufacturer of liquid products,for personal care, infection ... recent shortages of mouth rinse in the healthcare ...
... BioSpace, the world,s leading,online bioscience job ... revealed,this morning the 2008 BioCapital(TM) Hotbed Campaign ... and Washington, D.C., (Photo: http://www.newscom.com/cgi-bin/prnh/20080602/CLM086 ... companies and academic institutions from,the biotechnology, pharmaceutical ...
... CLEVELAND, Ohio, June 2 Simbionix has announced ... its LAP Mentor simulator that,gives trainees hands-on experience ... of ectopic pregnancy, tubal,sterilization and oophorectomy., The ... suite of laparoscopic,procedures developed for the LAP Mentor, ...
Cached Biology Technology:Medline Signs 3-Year Purchasing Agreement for Mouth Rinse From Chester Labs 2BioSpace Releases the 2008 BioCapital(TM) Hotbed Campaign 2Simbionix Takes Non-Invasive GYN Surgical Training to the Next Level 2
(Date:12/19/2014)... 18, 2014 Research and Markets ( ... "Micro Market Monitor: North America Perimeter Security Systems Market" ... http://photos.prnewswire.com/prnh/20130307/600769 The North American perimeter ... of 3.6% from 2014 to 2019. Although the U.S. ... Canada is expected to grow at ...
(Date:12/17/2014)... NEW YORK , Dec. 15, 2014 /PRNewswire-USNewswire/ ... a Good Clinical Practices (GCP) audit to confirm ... Administration (FDA) regulations. This accomplishment enables HITLAB to ... trials utilizing the highest principles for patient safety ... to improve global healthcare access, quality, and delivery ...
(Date:12/11/2014)... 09, 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/twhjll/biometrics_market ) has announced the addition ... Region 2015-2019"  report to their offering. ... is advances in technology. With continuous advances in ... to the latest standard that meets the needs ...
Breaking Biology News(10 mins):Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2
... brassinolide, plants "pump up" like major league baseball players ... cell's nucleus, researchers at the Salk Institute for Biological ... job at the molecular level. , The Salk ... Plant Molecular and Cellular Biology Laboratory and a Howard ...
... plant steroid brassinolide, plants "pump up" like major league ... into the cell's nucleus, researchers at the Salk Institute ... accomplishes its job at the molecular level. , ... in the Plant Molecular and Cellular Biology Laboratory and ...
... foods to cause allergic reactions in humans is a ... are in place to ask questions about the allergy-causing ... answers. , But all of that could change as ... animal model to test whether genetically engineered foods could ...
Cached Biology News:Ozone recovering, but unlikely to stabilize at pre-1980 levels, says study 2Ozone recovering, but unlikely to stabilize at pre-1980 levels, says study 3Salk scientists untangle steroid hormone signaling in plants 2Salk scientists untangle steroid hormone signaling in plants 3Tests may help answer questions about GMOs and allergies 2
... Staining Kit, 1. Select from homogeneous ... peptides on denaturing, native, and isoelectric ... with precast gels, buffer strips, and ... that of radioisotopes with ready-to-use silver ...
ANTI S. ENT TOX BC2D...
Porcine Serum US Origin 6 Months or Older...
... Silver Staining Kit, Protein, 1. Based ... Dernick (1), the kit gives essentially ... systems.Silver Staining Kit, Protein provides convenient, ... in polyacrylamide gels in less than ...
Biology Products: