TITLE: B cell depletion: a novel therapy for autoimmune diabetes?
Jeffrey A. Bluestone
University of California at San Francisco, San Francisco, California, USA.
Phone: (415) 514-1683; Fax: (415) 564-5813; E-mail: firstname.lastname@example.org.
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TRANSPLANTATION: Get an extended warranty on your new lung: Artery reattachment may be the key to long-term transplant survival
Small-airway fibrosis, the chronic scarring and subsequent occlusion of the lung airways, is a major contributor to death following lung transplantation. Once the diagnosis of fibrosis is made, a patients chances of survival are very poor. The functionality of small vessels feeding the transplanted organ is likely to play a key role in preventing fibrosis and improving long-term patient survival, according to new research in a mouse model of airway (trachea) transplantation from Mark Nicolls and colleagues at the VA Palo Alto Health Care System.
Lung transplantation is the only same-species transplant surgery not followed by reconnection of the arteries, a process known as revascularization. Because a loss of blood flow (ischemia) and subsequent loss of oxygen (hypoxia) are almost always harmful to organ tissues, researchers examined the functionality of mouse blood vessels following tracheal transplants where surgical revascularization was not performed. In rejected organs, prior to fibrosis of the trachea being observed, researchers found deposition of immune proteins on the blood vessel walls, as well as an absence of blood flow through the vessels. This inflammation-induced ischemia resulted in tissue hypoxia, as the oxygen content of the tra
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Journal of Clinical Investigation