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JCI table of contents: Dec. 3, 2007
Date:12/3/2007

ary, the results of this work point to the interaction between OX40 and its partner protein, OX40L, as a promising therapeutic target for the treatment of allergic diseases.

In the study, blocking OX40/OX40L interactions reduced allergic responses in mice with TSLP-induced inflammation of the lungs or skin and in mice with chronic or acute asthma. In addition, the same approach reduced allergic responses in monkeys with dust-mite induced allergic asthma. The reduction in the severity of the allergic response was associated with a decrease in the generation of inflammatory cells and proteins, as well as the production of immune cells.

TITLE: In vivo blockade of OX40 ligand inhibits thymic stromal lymphopoietin driven atopic inflammation

AUTHOR CONTACT:
Flavius Martin
Genentech Inc., South San Francisco, California, USA
Phone: (650) 225-2731; Fax: (650) 225-8221; E-mail: flavius@gene.com.

View the PDF of this article at: https://www.the-jci.org/article.php?id=33559

ACCOMPANYING COMMENTARY
TITLE: OX40-OX40L interactions: a promising therapeutic target for allergic diseases?

AUTHOR CONTACT:
Yong-Jun Liu
The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
Phone: (713) 563-3203; Fax: (713) 563-3275; E-mail: yjliu@mdanderson.org

Yui-Hsi Wang
The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
Phone: (713) 563-3306; Fax: (713) 563-3275; E-mail: yuiwang@mdanderson.org

View the PDF of this article at: https://www.the-jci.org/article.php?id=34182


AUTOIMMUNITY: Treating type 1 diabetes by eliminating B cells

Autoimmune diseases such as type 1 diabe
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Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

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