Navigation Links
JCI table of contents: Dec. 3, 2007
Date:12/3/2007

ht be possible to construct ever-better agents that can be combined safely and effectively to manage, and eventually cure, many forms of human cancer.

TITLE: An anticancer C-Kit kinase inhibitor is reengineered to it more active and less cardiotoxic

AUTHOR CONTACT:
Ariel Fernndez
Rice University, Houston, Texas, USA.
Phone: (713) 348-3681; Fax: (713) 348-3699; E-mail: arifer@rice.edu.

MEDIA CONTACT:
Jade C. Boyd
Associate Director of News & Media Relations
Rice University, Houston, Texas, USA.
Phone: (713) 348-6778; E-mail: jadeboyd@rice.edu.

View the PDF of this article at: https://www.the-jci.org/article.php?id=32373

ACCOMPANYING COMMENTARY
TITLE: Structural reengineering of imatinib to decrease cardiac risk in cancer therapy

AUTHOR CONTACT:
George D. Demetri
Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Phone: (617) 632-3985; Fax: (617) 632-3408; E-mail: gdemetri@partners.org.

View the PDF of this article at: https://www.the-jci.org/article.php?id=34252


EDITOR'S PICK: Giving asthma T(he)SL(i)P by blocking OX40

Inflammatory disorders such as asthma and eczema are overzealous immune responses by the body to otherwise innocuous environmental conditions. The protein TSLP is a potent activator of the allergic inflammatory response, and a new report by Flavius Martin and colleagues at Genentech Inc., San Francisco, has identified a role for another protein, OX40, in TSLP-induced allergic reactions in mice and monkeys. As indicated by the authors and Yui-Hsi Wang and Yong-Jun Liu from The University of Texas MD Anderson Cancer Center, Houston, in an accompanying comment
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8 9 10 11 12 13

Related biology technology :

1. Ranexa(R) Added to New ACC/AHA Guidelines on Unstable Angina/Non ST-Elevation Myocardial Infarction (UA/NSTEMI)
2. AUDIO from Medialink and GlaxoSmithKline: Fiber Key in Managing Irritable Bowel Syndrome (IBS) Symptoms
3. Lexicon Presents Class of Compounds Modulating TPH1, the Target for its LX1031 Investigational Drug for Irritable Bowel Syndrome
4. FDA Accepts Sucampos sNDA for Lubiprostone (8 mcg) for the Treatment of Irritable Bowel Syndrome with Constipation (IBS-C)
5. Sheet of carbon atoms acts like a billiard table, physicists find
6. Sheet of carbon atoms acts like a billiard table, physicists find
7. New Phase III Data Demonstrate Oxycodone / Naloxone Combination Tablet Reduces Opioid-Induced Bowel Dysfunction in Patients With Chronic Severe Pain
8. Caraco Pharmaceutical Laboratories, Ltd. Announces FDA Approval to Market Methimazole Tablets USP, 5 mg and 10 mg
9. Dey L.P. and Critical Therapeutics Launch Twice-Daily ZYFLO CR(TM) (Zileuton) Extended-Release Tablets for the Chronic Treatment of Asthma
10. FDA Approves New 300mg Loading Dose Tablet for PLAVIX(R) (clopidogrel bisulfate)
11. CV Therapeutics Submits Supplemental New Drug Application for Ranexa(R) (ranolazine extended-release tablets)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/19/2014)... Mass. , Oct. 19, 2014 NextCODE Health, ... the whole genome in real time, today announced the launch ... NextCODE Exchange , at the American Society of Human ... . To learn more, sign up and apply for free ... its unique features and benefits can be viewed here ...
(Date:10/19/2014)... (PRWEB) October 19, 2014 The Asian ... in Asian with analysis and forecast of revenue. The ... grow to around $463.9 million by 2018, at a ... Browse through the TOC of the Asian Automatic patient ... analysis provided. This also provides a glimpse of the ...
(Date:10/19/2014)... report "Chocolate, Cocoa Beans, Lecithin, Sugar and Vanilla Market ... (2011 - 2016)," analyzes the chocolate market by ... market drivers, restraints, and opportunities for the chocolate market ... chocolate market is expected to grow from $83.2 billion ... CAGR of 2.7% from 2011 to 2016. , Get ...
(Date:10/19/2014)... 19, 2014 The report "Unmanned ... Homeland Security), Technology, Payload, Type & by Geography ... the global unmanned ground vehicle market into various ... of market sizes. The report also identifies the ... impacting it along with the adoption trends. , ...
Breaking Biology Technology:The NextCODE Exchange: The first global, real-time system for sharing full-resolution genomic data 2The NextCODE Exchange: The first global, real-time system for sharing full-resolution genomic data 3The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 2The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 3Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 2Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 3Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 4Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 2Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 3Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 4Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 5
... March 7, 2011 Reportlinker.com announces that a ... catalogue: Biomarkers - Technologies,markets and ... SummaryThis report follows the broad definition ... be objectively measured and evaluated as an indicator ...
... 7, 2011 Gene Codes Corporation has pulled back ... release of Sequencher® with support for Next Generation Sequencing ... of Biomolecular Resource Facilities [ABRF] in San Antonio, Gene ... SOLiD, Illumina and 454 instruments. Conference attendees were given ...
... measurement in the world of nanoparticles has now become a ... The UCSB research team has developed a new instrument ... a few tens of nanometers. The study will be published ... appear in the April print issue of the journal. ...
Cached Biology Technology:Reportlinker Adds Biomarkers - Technologies, Markets and Companies 2After the ABRF Conference: Gene Codes Flooded with Requests for Early Access to NextGen Software Tools 2After the ABRF Conference: Gene Codes Flooded with Requests for Early Access to NextGen Software Tools 3New instrument keeps an 'eye' on nanoparticles 2
(Date:10/17/2014)... To date, antidotes ... doctors are often limited to supportive therapy such as induced ... of drugs involved. So what can be done if a ... professor Jean-Christophe Leroux from the Institute of Pharmaceutical Sciences at ... "The task was to develop an agent that could eliminate ...
(Date:10/16/2014)... and Mary,s Virginia Institute of Marine Science have ... Protection Agency to identify the streams and wetlands ... tools to help local governments and citizens conserve ... on a dataset of tidal-marsh observations first gathered ... this historical baseline can today,s researchers accurately map ...
(Date:10/16/2014)... the bowel lining develops and, in the process, suggested ... The researchers produced evidence that stem cells are responsible ... feature of the bowel lining, and believe these stem ... finding as scientists are still divided on the stem ... Wee Tan and Professor Tony Burgess from the Walter ...
Breaking Biology News(10 mins):Emergency aid for overdoses 2Emergency aid for overdoses 3EPA grant will help localities conserve headwater wetlands 2EPA grant will help localities conserve headwater wetlands 3Cryptic clues drive new theory of bowel cancer development 2
... to stop the spread of drug resistance in typhoid fever, ... published in the journal eLife . The ... bacteria can out-compete drug sensitive strains when grown in the ... is transmitted by consuming food or drink that is contaminated ...
... 9, 2013 /PRNewswire-iReach/ -- With the holiday season comes the ... American will put on up to five pounds in just ... CDC (Center for Disease Control) more than 65% of Americans ... obese. (Photo: http://photos.prnewswire.com/prnh/20131209/MN29878 ) ...
... inhibitors (SSRIs) are the most commonly prescribed antidepressants, but ... often try several different SSRI medications, each with a ... is effective. It takes three to four weeks to ... and their families continue to suffer. Now researchers ...
Cached Biology News:Antibiotic-resistant typhoid likely to spread despite drug control program 2HCG Injections and B12 shots now in stock at US Vitamin Injections Site 2A personal antidepressant for every genome 2A personal antidepressant for every genome 3
Cell Culture Flask, nontreated polystyrene...
iNOS/NOS Type II Purified Anti-Mouse, Anti-Rat, Anti-Human clone Polyclonal, Isotype Rabbit Ig, 150 µg Consult technical datasheet for details....
...
... This high pressure gradient system ... piston pumps and the Adept CE 4200 dual ... and data processing is provided by PowerStream data ... heater/chillers can be supplied. The supplied ...
Biology Products: