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JCI table of contents: Dec. 3, 2007

ht be possible to construct ever-better agents that can be combined safely and effectively to manage, and eventually cure, many forms of human cancer.

TITLE: An anticancer C-Kit kinase inhibitor is reengineered to it more active and less cardiotoxic

Ariel Fernndez
Rice University, Houston, Texas, USA.
Phone: (713) 348-3681; Fax: (713) 348-3699; E-mail:

Jade C. Boyd
Associate Director of News & Media Relations
Rice University, Houston, Texas, USA.
Phone: (713) 348-6778; E-mail:

View the PDF of this article at:

TITLE: Structural reengineering of imatinib to decrease cardiac risk in cancer therapy

George D. Demetri
Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Phone: (617) 632-3985; Fax: (617) 632-3408; E-mail:

View the PDF of this article at:

EDITOR'S PICK: Giving asthma T(he)SL(i)P by blocking OX40

Inflammatory disorders such as asthma and eczema are overzealous immune responses by the body to otherwise innocuous environmental conditions. The protein TSLP is a potent activator of the allergic inflammatory response, and a new report by Flavius Martin and colleagues at Genentech Inc., San Francisco, has identified a role for another protein, OX40, in TSLP-induced allergic reactions in mice and monkeys. As indicated by the authors and Yui-Hsi Wang and Yong-Jun Liu from The University of Texas MD Anderson Cancer Center, Houston, in an accompanying comment

Contact: Karen Honey
Journal of Clinical Investigation

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