JCI table of contents: Dec. 3, 2007(t lack the protein Gata-1 rendering them...)

Date:12/3/2007

t lack the protein Gata-1, rendering them incapable of further differentiation. When G1ME cells were engineered to produce STAT1, a protein that is expressed in response to inflammatory markers, they displayed distinguishing characteristics of megakaryocytic differentiation, including the expression of genes found in platelets and chromosomal duplication. Similarly, megakaryocytes from mice deficient in STAT1 lacked the chromosomal duplication inherent to this cell type. The authors concluded from these results that inflammatory stimulation of STAT1 can lead to thrombocytosis through enhanced differentiation of platelet precursor cells.

TITLE: STAT1 promotes megakaryopoiesis downstream of GATA-1 in mice

AUTHOR CONTACT:
John D. Crispino
Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Phone: (312) 503-1504; Fax: (312) 503-0189; E-mail: j-crispino@northwestern.edu.

View the PDF of this article at: https://www.the-jci.org/article.php?id=33010

'/>"/>

Contact: Karen Honey press_releases@the-jci.org 215-573-1850 Journal of Clinical Investigation Source:Eurekalert

2 GOOD

Page: 1 2 3 4 5 6 7 8 9 10 11 12 13
Related biology technology :

1. Ranexa(R) Added to New ACC/AHA Guidelines on Unstable Angina/Non ST-Elevation Myocardial Infarction (UA/NSTEMI)
2. AUDIO from Medialink and GlaxoSmithKline: Fiber Key in Managing Irritable Bowel Syndrome (IBS) Symptoms
3. Lexicon Presents Class of Compounds Modulating TPH1, the Target for its LX1031 Investigational Drug for Irritable Bowel Syndrome
4. FDA Accepts Sucampos sNDA for Lubiprostone (8 mcg) for the Treatment of Irritable Bowel Syndrome with Constipation (IBS-C)
5. Sheet of carbon atoms acts like a billiard table, physicists find
6. Sheet of carbon atoms acts like a billiard table, physicists find
7. New Phase III Data Demonstrate Oxycodone / Naloxone Combination Tablet Reduces Opioid-Induced Bowel Dysfunction in Patients With Chronic Severe Pain
8. Caraco Pharmaceutical Laboratories, Ltd. Announces FDA Approval to Market Methimazole Tablets USP, 5 mg and 10 mg
9. Dey L.P. and Critical Therapeutics Launch Twice-Daily ZYFLO CR(TM) (Zileuton) Extended-Release Tablets for the Chronic Treatment of Asthma
10. FDA Approves New 300mg Loading Dose Tablet for PLAVIX(R) (clopidogrel bisulfate)
11. CV Therapeutics Submits Supplemental New Drug Application for Ranexa(R) (ranolazine extended-release tablets)