Navigation Links
JCI table of contents: April 22, 2008
Date:4/22/2008

hone: 33-1-46-54-94-69; Fax: 33-1-46-54-77-26; E-mail: stephane.prost@cea.fr.

View the PDF of this article at: https://www.the-jci.org/article.php?id=33037

ACCOMPANYING COMMENTARY
TITLE: Is Nef the elusive cause of HIV-associated hematopoietic dysfunction?

AUTHOR CONTACT:
Frank Kirchhoff
University of Ulm, Ulm, Germany.
Phone: 49-731-50065109; Fax: 49-731-50065131; E-mail: frank.kirchhoff@uniklinik-ulm.de.

Guido Silvestri
University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Phone: (215) 573-5363; Fax: (215) 573-5366; E-mail: gsilvest@mail.med.upenn.edu.

View the PDF of this article at: https://www.the-jci.org/article.php?id=35487


ONCOLOGY: Downfall of some tumor cells is their reliance on just one of three cyclin D proteins

Unlike normal cells, which have three cyclin D proteins that can each cover for the others, the cells of many types of cancer, especially blood cancers such as multiple myeloma, express only one cyclin D protein. This has led to the suggestion that targeting individual cyclin D proteins might provide a good approach to treating individuals with cancers characterized by a reliance on just one cyclin D protein. Evidence to support this idea has now been generated in preclinical models by Keith Stewart and colleagues, at the Mayo Clinic in Scottsdale, Arizona.

In the study, a large number of chemicals were screened for their ability to inhibit the expression of the CCND2 gene, which is the gene that carries the information for making the cyclin D2 protein. During the screen, a chemical from plants known as kinetin riboside was shown to inhibit expression of both
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8 9 10 11 12

Related biology technology :

1. Perceptive Informatics Improves Clinical Site Monitoring Access and Flexibility With Portable USB Drive Capability
2. Actavis Receives Approval of Generic Wellbutrin SR(R) and Zyban(R) Tablets in the U.S.
3. Epeius Biotechnologies Awarded U.S. Patent for Targeted Injectable Gene Delivery In Vivo
4. Tianyin Pharmaceutical Announces SFDA Approval to Market Azithromycin Dispersible Tablets
5. Altogen Biosystems Launches Custom Biotechnology Research Services: Generation of Stable Cell Lines and RNAi Cell Transfection Services
6. JCI online early table of contents: March 6, 2008
7. New 300mg Loading Dose Tablet for Plavix(R) Receives Positive Opinion From the European Committee for Medicinal Products (CHMP)
8. Genmab and Pepscan to Identify Human Antibodies Against Intractable Targets
9. STAAR Surgical Receives Approval to Market Visian(R) Toric Implantable Collamer Lens in China
10. Actavis Receives Approval for Irinotecan Hydrochloride Injection; Extends US Portfolio with First Injectable Product
11. Beijing 2008 Olympic Games Vegetable Supplier Considering Kiwa as a Supplier of Bio-Fertilizers & Kiwa Announces CEO Interview with WallSt.net
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... (PRWEB) September 18, 2014 ... urological and interventional radiology products and services, announced ... as cryotherapy and cryoablation) versus external beam radiotherapy ... of the American Urological Association (MAAUA) Annual Meeting ... "Comparing Relative Effectiveness of Cryosurgery and External Beam ...
(Date:9/18/2014)... 18, 2014 ... ) has announced the addition of ... Strategic Business Report" report to ... report analyzes the worldwide markets for ... the following Product Segments: Polymeric Materials, ...
(Date:9/18/2014)... Research and Markets has announced the addition ... report to their offering. The ... and in-depth study on the current state of the ... a basic overview of the industry including definitions, classifications, ... analysis is provided for the international markets including development ...
(Date:9/18/2014)... , Sept. 18, 2014  Neogen Corporation (Nasdaq: ... entered into a strategic agreement with Merck Animal Health ... The Igenity Dairy Heifer Program consists ... information on the genetic potential of replacement dairy heifers. ... calf is born, and is an excellent tool in ...
Breaking Biology Technology:HealthTronics Announces Data Comparing Cryotherapy Versus Radiation for Treating Prostate Cancer Poster Presented at the American Urological Association Regional Meeting 2Biocompatible Materials - Global Strategic Business Report 2014 2Biocompatible Materials - Global Strategic Business Report 2014 3Global Human Albumin Industry Report 2014 2Global Human Albumin Industry Report 2014 3Merck Animal Health to market Neogen's dairy genomic program 2
... , Amsterdam Molecular Therapeutics (Euronext: AMT), ... today that it has filed,a request for re-examination of ... European Medicines Agency.,Glybera is a gene therapy for the ... re-examination of,the dossier will be completed by the end ...
... a combination of sophisticated computer modeling and advanced ... team led by the University at Buffalo (UB) ... Technology (NIST), the Molecular Foundry at Lawrence Berkeley ... relatively simple processing flaws can seriously degrade the ...
... 7, 2011 For the first time since stem ... isolated a human blood stem cell in its purest ... regenerating the entire blood system. This breakthrough opens the ... to treat cancer and other debilitating diseases more effectively. ...
Cached Biology Technology:Amsterdam Molecular Therapeutics Files Glybera® European Marketing Application for Re-examination 2Graphene: What can go wrong? new studies point to wrinkles, process contaminants 2"Pure" Human Blood Stem-Cell Discovery Opens Door to Expanding Cells for More Clinical Use 2"Pure" Human Blood Stem-Cell Discovery Opens Door to Expanding Cells for More Clinical Use 3
(Date:9/18/2014)... icy moon of Uranus, is one of the most ... Despite its relatively small size, Miranda appears to have ... the formation of at least three remarkable and unique ... These coronae are visible in Miranda,s southern hemisphere, and ... corona, the largest, has ridges and troughs with up ...
(Date:9/18/2014)... Mass. A novel robotic system that can operate ... being tested as part of a biomedical research partnership ... the aim of determining if the robot, in conjunction ... faster, more accurate, less costly, and less discomforting for ... to deliver prostate cancer therapies with greater precision. , ...
(Date:9/18/2014)... Space Station ever starts a "frequent flyers" program, fruit ... the orbiting laboratory has hosted increasing numbers of fruit ... the space station in April, and another is scheduled ... is planned to launch in December. , Fruit flies ... world-- and in space. Model organisms can reveal the ...
Breaking Biology News(10 mins):Miranda: An icy moon deformed by tidal heating 2Miranda: An icy moon deformed by tidal heating 3Miranda: An icy moon deformed by tidal heating 4Miranda: An icy moon deformed by tidal heating 5Miranda: An icy moon deformed by tidal heating 6Miranda: An icy moon deformed by tidal heating 7Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 2Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 3Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 4Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 5Buzzing with activity: Fruit flies orbit Earth for science 2Buzzing with activity: Fruit flies orbit Earth for science 3Buzzing with activity: Fruit flies orbit Earth for science 4
... abundant in desert regions where fresh water is usually in ... Writing in International Journal of Global Environmental Issues , ... Rotterdam, The Netherlands, has hit on the idea of using ... the water locked in gypsum. Fresh water resources are ...
... 10 Stanley, Inc. (NYSE:,SXE), a leading provider ... federal government, announced today that it has entered ... (Oberon), an,engineering, intelligence operations and information technology services,company. ... in cash,subject to certain working capital and other ...
... Scientists at the Institute of Food Research have detected subtle ... development of tumours. With support from the Food ... they are investigating whether diet could control these changes and ... at changes in 18 genes that play a role in ...
Cached Biology News:Rocky water source 2Stanley to Acquire Oberon Associates 2Stanley to Acquire Oberon Associates 3Stanley to Acquire Oberon Associates 4'Addicted' cells provide early cancer diagnosis 2
Mouse monoclonal antibody raised against a partial recombinant SCARB2. NCBI Entrez Gene ID = SCARB2...
...
Mouse polyclonal antibody raised against a partial recombinant CSRP3. NCBI Entrez Gene ID = 8048...
... HDAC8 Regulation of gene expression ... as DNA methylation, ATP-dependent chromatin remodeling, ... which include the dynamic acetylation and ... residues present in the tail of ...
Biology Products: