Navigation Links
JCI table of contents: April 22, 2008
Date:4/22/2008

s thought to cause this problem by disrupting the function of cells that are the precursors of all blood cells; these cells are known as hematopoietic progenitor cells. Exactly how HIV affects hematopoietic progenitor cells has not been determined, although it seems to be an indirect effect as the cells are not themselves infected with HIV. New data, generated by Stphane Prost and colleagues, at the Institute of Emerging Disease and Innovative Therapies, CEA, France, have now indicated that the HIV protein Nef disrupts the function of hematopoietic progenitor cells.

In the study, production of the protein Nef was shown to be essential for the monkey form of HIV (SIV) to disrupt hematopoietic progenitor cell function in vivo and ex vivo. The ability of both SIV and HIV Nef to cause this problem was dependent on the hematopoietic progenitor cells expressing the protein PPAR-gamma. Further, when PPAR-gamma agonists were administered to macaques they impaired hematopoietic progenitor cell function. Disruption of hematopoietic progenitor cell function by both PPAR-gamma agonists and SIV and HIV Nef was associated with downregulation of the signaling molecules STAT5A and STAT5B, indicating that Nef is likely to impair blood cell development by targeting a PPAR-gamma/STAT5 signaling pathway. The authors have therefore suggested that PPAR-gamma antagonists might be of benefit to both individuals infected with HIV and those with blood celldeficiency disorders. As noted by the authors and, in an accompany commentary, Frank Kirchhoff and Guido Silvestri, these data also have implications for PPAR-gamma agonists, which are currently used to treat individuals with type 2 diabetes.

TITLE: Human and simian immunodeficiency viruses deregulate early hematopoiesis through a Nef/PPAR-gamma/STAT5 signaling pathway in macaques

AUTHOR CONTACT:
Stphane Prost
Institute of Emerging Disease and Innovative Therapies, CEA, Fontenay-aux-Roses, France.
P
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8 9 10 11 12

Related biology technology :

1. Perceptive Informatics Improves Clinical Site Monitoring Access and Flexibility With Portable USB Drive Capability
2. Actavis Receives Approval of Generic Wellbutrin SR(R) and Zyban(R) Tablets in the U.S.
3. Epeius Biotechnologies Awarded U.S. Patent for Targeted Injectable Gene Delivery In Vivo
4. Tianyin Pharmaceutical Announces SFDA Approval to Market Azithromycin Dispersible Tablets
5. Altogen Biosystems Launches Custom Biotechnology Research Services: Generation of Stable Cell Lines and RNAi Cell Transfection Services
6. JCI online early table of contents: March 6, 2008
7. New 300mg Loading Dose Tablet for Plavix(R) Receives Positive Opinion From the European Committee for Medicinal Products (CHMP)
8. Genmab and Pepscan to Identify Human Antibodies Against Intractable Targets
9. STAAR Surgical Receives Approval to Market Visian(R) Toric Implantable Collamer Lens in China
10. Actavis Receives Approval for Irinotecan Hydrochloride Injection; Extends US Portfolio with First Injectable Product
11. Beijing 2008 Olympic Games Vegetable Supplier Considering Kiwa as a Supplier of Bio-Fertilizers & Kiwa Announces CEO Interview with WallSt.net
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2015)... 2015 DryLet, LLC a biotechnology ... such as animal waste reduction, bioremediation, wastewater treatment, ... wastewater treatment plants and restaurant kitchen settings, announced ... National Restaurant Association’s NRA Show 2015, in Chicago, ... the company will be available to share information ...
(Date:4/24/2015)... April 24, 2015 /CNW Telbec/ - Mirego, leader in mobile ... making of three mobile app extensions for the all new ... its clients, Familiprix, OMSignal and MediaMiser, these extensions will reinvent ... functions designed specifically for wrist use.  Available ... is a highly customizable tactile smartwatch that makes for an ...
(Date:4/24/2015)... Seoul Semiconductor announced the expansion of ... the lighting market. In recent months, there ... in emerging markets such as Russia, South America, ... applications such as streetlight and area lighting, tunnel ... launched in 2005 the Acrich technology from Seoul ...
(Date:4/23/2015)... Dora, Florida (PRWEB) April 23, 2015 ... that it intends to conduct a groundbreaking pilot ... begin to be reversed in as little as ... the science of metabolic and nutritional medicine—will aggressively ... that cripple and destroy our aging brain. These ...
Breaking Biology Technology:DryLet to Showcase Bio-React at the National Restaurant Association’s NRA Show 2015 May 16-19, 2015 in Chicago, Illinois 2Familiprix, OMSignal and MediaMiser apps available today for Apple Watch 2Acrich Technology from Seoul Semiconductor Adopted in Installations Worldwide 2New Study Looks to Reverse Alzheimer’s Disease 2New Study Looks to Reverse Alzheimer’s Disease 3
... Hu of China - Source: Getty Images The Olympics ... four years. They're held every year. Though this is still ... as the pervasive growth of the industry becomes part of ... every four years and last two weeks, the biotech Olympics ...
... MADISON, Wis. - Ownership and accountability is the way ... 448-bed community hospital in Madison that provides medical care ... living facility, laboratories and a home health care service. ... Methodist Hospital in 1987, Meriter includes more than 430 ...
... trend three years ago many companies cut their information ... the price of computers dropped, allowing businesses to inexpensively ... grew. Many IT staffers are wary of returning to ... looked to begin working as an outside IT source, ...
Cached Biology Technology:The Olympics: A Biotech Perspective 2The Olympics: A Biotech Perspective 3Meriter IT team builds project performance through internal relationships 2Meriter IT team builds project performance through internal relationships 3Meriter IT team builds project performance through internal relationships 4Expetec expands IT staff services in Wisconsin 2Expetec expands IT staff services in Wisconsin 3
(Date:4/14/2015)... 2015  HYPR Corp. today announced it has ... Alliance tm , an industry consortium transforming online ... share technology and collaborate to deliver open specifications ... secure and private, and easier to use. ... protects sensitive user information and eliminates the dependency ...
(Date:4/13/2015)... According to a recently ... & Opportunities, 2020", the global biometrics market is ... till 2020. The biometrics market is garnering attention ... review of biometric management systems. The constant development ... greater efficiency, are resulting in increasing installation of ...
(Date:4/10/2015)... -- Research and Markets ( http://www.researchandmarkets.com/research/cjk4gb/security ) ... Profiles - NEC" report to their offering. ... continue to supply a range of IT security management ... focus on the development of a Big Data and ... the Asia-Pacific region is a ...
Breaking Biology News(10 mins):HYPR Corp. Joins the FIDO Alliance 2HYPR Corp. Joins the FIDO Alliance 3Global Biometrics Market to Cross US$ 21 Billion by 2020: TechSci Research 2NEC Security Competitive Profile 2015 2
... screening the genome of hundreds of thousands of individuals ... more than 100 regions in the genome to the ... Molecular Biology Laboratory (EMBL) and the University of Heidelberg, ... taking these results one step further by pinpointing the ...
... 2013) "Green" chemistry developed at Rice University is at ... waste into fatty acids, and then into fuel. The ... recently announced $25 million United States Department of Agriculture project ... products from switchgrass and forestry residues and from a new ...
... have been a source of great controversyparticularly in Europebut ... scientific evidence about the health and ecological impacts of ... field site dedicated for use in GM crop studies ... interested in pursuing crop biotechnology, according to an article ...
Cached Biology News:Zeroing in on heart disease 2Modified bacteria turn waste into fat for fuel 2Modified bacteria turn waste into fat for fuel 3Fighting GM crop vandalism with a government-protected research site 2
Rabbit polyclonal to GABA A Receptor gamma 2 ( Abpromise for all tested applications). entrezGeneID: 2566 SwissProtID: P18507...
Rabbit polyclonal to VPAC2 ( Abpromise for all tested applications). entrezGeneID: 7434 SwissProtID: P41587...
Anti-GOSR2 Monoclonal AntibodyOther Sub-Family: not assigned-Other Applications: Immunocytochemistry, Immunoprecipitation, Western Blot...
Mouse monoclonal [4A2.2] to SLC6A4 ( Abpromise for all tested applications). entrezGeneID: 6532 SwissProtID: P31645...
Biology Products: