Navigation Links
JCI table of contents: April 22, 2008
Date:4/22/2008

s thought to cause this problem by disrupting the function of cells that are the precursors of all blood cells; these cells are known as hematopoietic progenitor cells. Exactly how HIV affects hematopoietic progenitor cells has not been determined, although it seems to be an indirect effect as the cells are not themselves infected with HIV. New data, generated by Stphane Prost and colleagues, at the Institute of Emerging Disease and Innovative Therapies, CEA, France, have now indicated that the HIV protein Nef disrupts the function of hematopoietic progenitor cells.

In the study, production of the protein Nef was shown to be essential for the monkey form of HIV (SIV) to disrupt hematopoietic progenitor cell function in vivo and ex vivo. The ability of both SIV and HIV Nef to cause this problem was dependent on the hematopoietic progenitor cells expressing the protein PPAR-gamma. Further, when PPAR-gamma agonists were administered to macaques they impaired hematopoietic progenitor cell function. Disruption of hematopoietic progenitor cell function by both PPAR-gamma agonists and SIV and HIV Nef was associated with downregulation of the signaling molecules STAT5A and STAT5B, indicating that Nef is likely to impair blood cell development by targeting a PPAR-gamma/STAT5 signaling pathway. The authors have therefore suggested that PPAR-gamma antagonists might be of benefit to both individuals infected with HIV and those with blood celldeficiency disorders. As noted by the authors and, in an accompany commentary, Frank Kirchhoff and Guido Silvestri, these data also have implications for PPAR-gamma agonists, which are currently used to treat individuals with type 2 diabetes.

TITLE: Human and simian immunodeficiency viruses deregulate early hematopoiesis through a Nef/PPAR-gamma/STAT5 signaling pathway in macaques

AUTHOR CONTACT:
Stphane Prost
Institute of Emerging Disease and Innovative Therapies, CEA, Fontenay-aux-Roses, France.
P
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8 9 10 11 12

Related biology technology :

1. Perceptive Informatics Improves Clinical Site Monitoring Access and Flexibility With Portable USB Drive Capability
2. Actavis Receives Approval of Generic Wellbutrin SR(R) and Zyban(R) Tablets in the U.S.
3. Epeius Biotechnologies Awarded U.S. Patent for Targeted Injectable Gene Delivery In Vivo
4. Tianyin Pharmaceutical Announces SFDA Approval to Market Azithromycin Dispersible Tablets
5. Altogen Biosystems Launches Custom Biotechnology Research Services: Generation of Stable Cell Lines and RNAi Cell Transfection Services
6. JCI online early table of contents: March 6, 2008
7. New 300mg Loading Dose Tablet for Plavix(R) Receives Positive Opinion From the European Committee for Medicinal Products (CHMP)
8. Genmab and Pepscan to Identify Human Antibodies Against Intractable Targets
9. STAAR Surgical Receives Approval to Market Visian(R) Toric Implantable Collamer Lens in China
10. Actavis Receives Approval for Irinotecan Hydrochloride Injection; Extends US Portfolio with First Injectable Product
11. Beijing 2008 Olympic Games Vegetable Supplier Considering Kiwa as a Supplier of Bio-Fertilizers & Kiwa Announces CEO Interview with WallSt.net
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2014)... (PRWEB) July 23, 2014 StemGenex® ... therapy in the US aimed at improving the lives ... newest clinical study for Parkinson’s disease. StemGenex believes ... stem cell therapy are paramount when providing care to ... study makes stem cell therapy accessible to the millions ...
(Date:7/23/2014)... Iowa (PRWEB) July 23, 2014 DuPont ... the business as vice president of Agricultural Biotechnology (ABT), ... Biotechnology where he served most recently as president, chief ... biotechnology and business leadership in the seed and crop ... said Paul E. Schickler , president of DuPont ...
(Date:7/23/2014)... , July 23, 2014 regulated information -- UCB ... and development pipeline with positive topline results from ... . This study was designed to evaluate the efficacy ... 200 mg/day, without titration) compared to placebo, as ... partial-onset seizures, not fully controlled despite treatment with ...
(Date:7/23/2014)... 23, 2014  GrowBLOX Sciences, Inc. (OTCQB: GBLX), a medical ... filing for two medical marijuana dispensary locations in ... to the Clark County, Nevada dispensary ... as previously announced.  GrowBLOX Sciences, CEO Craig ... new applications for dispensaries in the City of ...
Breaking Biology Technology:StemGenex® Gives Hope to Parkinson’s Patients through New Stem Cell Clinical Study 2StemGenex® Gives Hope to Parkinson’s Patients through New Stem Cell Clinical Study 3DuPont Pioneer Names Neal Gutterson to Lead Agricultural Biotechnology 2DuPont Pioneer Names Neal Gutterson to Lead Agricultural Biotechnology 3Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 2Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 3Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 4Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 5Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 6Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 7GrowBLOX Sciences, Inc. Files for Two Additional Medical Marijuana Dispensaries in Las Vegas 2GrowBLOX Sciences, Inc. Files for Two Additional Medical Marijuana Dispensaries in Las Vegas 3
... Va., June 20 Insmed Inc. (Nasdaq:,INSM), a ... it intends to request a hearing before The ... earlier Staff Determination,to delist the Company,s common stock ... a letter from The NASDAQ Stock Market ("NASDAQ") ...
... June 20, 2008 / b3c newswire / ... organization (CMO) for the development and production of ... 2,500 L multi-process production suite. Hence, Rentschler Biotechnologie ... of 30, 250, 500 and 2,500 liters, allowing ...
... InterMune, Inc.,(Nasdaq: ITMN ) today announced that ... InterMune, will present at the Jefferies 2nd,Annual Healthcare Conference ... p.m. EDT., To access a live audio webcast ... on to the investor relations page of InterMune,s,corporate website ...
Cached Biology Technology:Insmed to Request Hearing Before NASDAQ Panel to Review NASDAQ Staff Determination 2Rentschler Biotechnologie Extends Capacities for Mammalian Cell Culture Manufacturing 2
(Date:7/23/2014)... , , , , ... , , , , ... extend healthy lifespan. The idea, they argue, would be to target the... , , ... , , , , , ... , , , , , , , Medicine focuses almost ...
(Date:7/23/2014)... has the entire country in its grip is affecting more ... responsible for the proliferation of a heat-loving amoeba commonly found ... springs, which the drought has made warmer than usual this ... infection caused by this parasite after swimming in several area ... an individual and travels to the brain. Nose plugs can ...
(Date:7/23/2014)... The planet,s soil releases about 60 billion tons of ... more than that released by burning fossil fuels. This ... release of carbon is balanced by carbon coming into ... matter, as well as by the underground activities of ... that rising temperatures increase the rate of soil respiration. ...
Breaking Biology News(10 mins):Strategy proposed for preventing diseases of aging 2Strategy proposed for preventing diseases of aging 3Strategy proposed for preventing diseases of aging 4Strategy proposed for preventing diseases of aging 5Diseases of another kind 2Climate change and the soil 2
... are ineffective and their continuation endangers ecosystems that ... worlds population depend, United Nations University experts warn ... for sweeping change. In a blunt assessment, ... Headquarters, New York, UNUs Canadian-based International Network on ...
... Biologist John Smol has been named as one of ... Royal Canadian Geographical Society. His half-brother, biologist Jules Blais, ... one of Canada,s most prestigious in the environmental sciences. ... work to Canadian society. Smol is series ...
... Atmel(R) Corporation (Nasdaq:,ATML), an inventor and leading ... that its FingerChip(R) fingerprint sensor,solution has been selected ... PC.,Rise will showcase this biometrics-capable LCD PC during ... as a standard feature enhances consumer,friendliness in the ...
Cached Biology News:Coastal management cooperation, enforcement key to avoid pending crisis for millions: U.N. experts 2Coastal management cooperation, enforcement key to avoid pending crisis for millions: U.N. experts 3Coastal management cooperation, enforcement key to avoid pending crisis for millions: U.N. experts 4Coastal management cooperation, enforcement key to avoid pending crisis for millions: U.N. experts 5Coastal management cooperation, enforcement key to avoid pending crisis for millions: U.N. experts 6Atmel's FingerChip Biometric Sensor Selected by Rise Computer for its Robust Security 2Atmel's FingerChip Biometric Sensor Selected by Rise Computer for its Robust Security 3
Request Info...
Services include subcloning into an expression vector. Tagged protein will be expressed in small scale for testing yield and solubility and then in 1L culture for large scale affinity purification. E...
Request Info...
...
Biology Products: