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JCI table of contents: April 22, 2008

ccompanying commentary by Tom Van Belle and Matthias von Herrath, at the La Jolla Institute for Allergy and Immunology.

TITLE: Islet transplantation in patients with autoimmune diabetes induces homeostatic cytokines that expand autoreactive memory T cells

Ezio Bonifacio
Dresden University of Technology, Dresden, Germany.
Phone: 49-0-351-463-40092; Fax: 49-0-351-463-40090; E-mail:

View the PDF of this article at:

TITLE: Immunosuppression in islet transplantation

Matthias von Herrath
La Jolla Institute for Allergy and Immunology, La Jolla, California, USA.
Phone: (858) 752-6817; Fax: (858) 752-6993; E-mail:

View the PDF of this article at:

NEUROBIOLOGY: One protein, opposite effects on a characteristic of some neurodegenerative disorders

One of the characteristics of the brain of people with Alzheimer disease (AD) is the presence of tangles, insoluble twisted fibers that build up inside the nerve cells of the brain resulting in malfunctions in communication between nerves and later in their death. As these tangles are due to abnormal aggregation of the tau protein, AD is classified as a tauopathy. Other tauopathies include the neurodegenerative disease frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17). Although the tau protein in individuals with AD is not mutated, mice carrying the mutated forms of tau found in individuals with FTDP-17 are often used as mouse models of AD. However, Kun Ping Lu and colleagues, at Harvard

Contact: Karen Honey
Journal of Clinical Investigation

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