Date:4/22/2008

bound a chemical known as phosphatidylserine that is found on the surface of microparticles, and that platelets exposed to microparticles were subsequently easier to activate. Importantly, under certain conditions, the formation of a thrombus in mice was delayed in the absence of CD36 and the thrombi that formed contained fewer microparticles derived from endothelial cells, which are the cells that line blood vessel walls. The rationale for the authors suggestion that CD36 might provide a useful target for the development of therapeutics to treat individuals with thrombotic disease is supported by the observation that endothelial cellderived microparticles are found in the blood of patients with several of these diseases.

TITLE: Platelet CD36 mediates interactions with endothelial cellderived microparticles and contributes to thrombosis in mice

AUTHOR CONTACT:
Roy L. Silverstein
Cleveland Clinic Foundation, Cleveland, Ohio, USA.
Phone: (216) 444-5220; Fax: (216) 444-9404; Email: silverr2@ccf.org.

View the PDF of this article at: https://www.the-jci.org/article.php?id=34904

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Contact: Karen Honey press_releases@the-jci.org 215-573-1850 Journal of Clinical Investigation Source:Eurekalert

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