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JCI online early table of contents: March 6, 2008
Date:3/6/2008

rgeting and somatic cell nuclear transfer

AUTHOR CONTACT:

Michael J. Welsh
University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
Phone: (319) 335-7619; Fax: (319) 335-7623; E-mail: michael-welsh@uiowa.edu.

Randall S. Prather
University of Missouri Columbia, Columbia, Missouri, USA.
Phone: (573) 882-6414; Fax: (573) 884-7827; E-mail: pratherr@missouri.edu.

View the PDF of this article at: https://www.the-jci.org/article.php?id=34773

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TITLE: Adeno-associated virustargeted disruption of the CFTR gene in cloned ferrets

AUTHOR CONTACT:
John F. Engelhardt
University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
Phone: (319) 335-7744; Fax: (319) 335-6581; E-mail: john-engelhardt@uiowa.edu.

View the PDF of this article at: https://www.the-jci.org/article.php?id=34599


HEMATOLOGY: Protein mutated in Shwachman-Diamond syndrome provides stability

Shwachman-Diamond syndrome (SDS) is an inherited disorder, caused by genetic mutations in the SBDS gene and characterized by, among other things, bone marrow failure and an increased risk of acute myeloid leukemia. New insight into the mechanisms underlying these symptoms has now been generated by a team of researchers from Childrens Hospital Boston and the University of Washington, Seattle, who analyzed human bone marrow stromal cells (BMSCs) and skin fibroblasts.

In BMSCs from healthy individuals the SBDS protein was found to be located at the mitotic spindle, a structure that forms when a cell is dividing, where it bound to and stabilized microtubules, protein filaments that function as structural components of a cell. Consistent with a role for SBDS in mitotic spindle stability, BMSCs from individua
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Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

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