Navigation Links
JCI online early table of contents: March 6, 2008
Date:3/6/2008

EDITOR'S PICK: Pinpoint accuracy: DNA vaccines that home in on DCs are more potent

One strategy being pursued to develop new vaccines against infectious diseases is DNA vaccination. The idea is that following administration of a DNA vaccine, the body converts the information in the DNA vaccine into a protein that activates an immune response. However, current DNA vaccines induce relatively weak immune responses even if administered multiple times. New data, generated in mice, by Ralph Steinman and colleagues, at the Rockefeller University, New York, has now identified a way to make DNA vaccines more potent.

In the study, mice were administered a DNA vaccine that included the information to make a single protein comprised of the HIV protein gp41 fused to a single-chain Fv antibody specific for DEC205. DEC205 is expressed by immune cells known as DCs, which show proteins from infectious organisms to immune cells known as T cells that then attack the infectious organism. The authors found that the single-chain Fv antibody specific for DEC205 targeted the protein made from the information in the DNA vaccine to DCs, such that it was expressed exclusively in DCs. Furthermore, this DNA vaccine induced a much stronger T cell response than DNA vaccines including information to make the HIV protein gp41 fused to an irrelevant single-chain Fv antibody, and it protected mice more efficiently from a virus engineered to express the HIV protein gp41. These data led to the suggestion that DNA vaccines might be more potent if the information they contain generates a protein that is targeted to DCs, for example by fusion to a single-chain Fv antibody specific for a DC surface molecule.

TITLE: The efficacy of DNA vaccination is enhanced in mice by targeting the encoded protein to dendritic cells

AUTHOR CONTACT:
Ralph M. Steinman
The Rockefeller University, New York, New York, USA.
Phone: (212) 327-8107; Fax: (212) 327-8875
'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4

Related biology technology :

1. Social Network for Scientists Marks Ten Years Online
2. BioReliance Corporation Launches iNet(TM) for Online Results Tracking of Biological Safety Tests
3. K-State Research Leading to Software to Help Nations Cattle Producers Identify Biosecurity Risks, Evaluate Impact of Cow-Calf Diseases Online
4. Bio Career Center Launches First Online Jobs Board for Life Science PhDs, MDs
5. New Online Help Desk Offers Safe Lifting Assistance to Healthcare Facilities
6. New Online Learning Tool Fills the Knowledge Gap on Botulinum Toxin Type B for Cervical Dystonia
7. Arpida-Supported CME Symposium Available Online
8. Online Career Site for Life Science Professionals Continues Growth
9. Reclast(R) Receives US FDA Approval as First and Only Once-Yearly Treatment for Women With Postmenopausal Osteoporosis
10. New technique can be breakthrough for early cancer diagnosis
11. The Tauri Group LLC Awarded U.S. Department of Homeland Security Chemical and Biological Early Detection Systems Program Office Support Contract
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)... 2014  Pomerantz LLP is investigating claims on behalf ... "Company") (NASDAQ: IPXL).  Such investors are advised to contact ... or 888-476-6529, ext. 237. The investigation concerns ... have violated Sections 10(b) and 20(a) of the Securities ... 29, 2014, Impax Laboratories, Inc. (the "Company") issued a ...
(Date:7/29/2014)... 29, 2014 A new report ... (types, applications and geography) - Size, Share, Global Trends, ... and Forecast, 2013 - 2020", suggests that the global ... by 2020 registering a CAGR of 11.1% from 2014 ... by the electro surgical devices in operative procedures by ...
(Date:7/29/2014)... 2014 Philadelphia’s newest entrepreneurial incubation space is ... start. The Innovation Center @3401 , a collaborative effort ... Science Center to help attract and nurture start-up businesses ... 28. , The Innovation Center @3401 (ic@3401), ... Streets, is the new home of DreamIt Ventures ...
(Date:7/29/2014)... July 29, 2014  United Therapeutics Corporation (NASDAQ: ... financial results for the second quarter ended ... shows that our medicines are reaching increasing ... hypertension (PAH)," said Martine Rothblatt, Ph.D., United ... commercial launch this quarter of our extended-release ...
Breaking Biology Technology:SHAREHOLDER ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Impax Laboratories, Inc. - IPXL 2Global Surgical Equipment Market is expected to reach $12.1 billion by 2020 - Allied Market Research 2Global Surgical Equipment Market is expected to reach $12.1 billion by 2020 - Allied Market Research 3Innovation Center @3401 Opens for Business; DreamIt Ventures and Point.io First Residents 2Innovation Center @3401 Opens for Business; DreamIt Ventures and Point.io First Residents 3United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 2United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 3United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 4United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 5United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 6United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 7United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 8United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 9United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 10United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 11United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 12United Therapeutics Corporation Reports Second Quarter 2014 Financial Results 13
... Toronto, Ontario - Cedara Software , a ... of medical software technologies, has released a new version ... toolkit, MergeCOM-3. , ,The product is a software development ... and supports flexible DICOM connectivity for software applications. , ...
... into the third year of their Sarbanes-Oxley ... is a good time to pause and reflect on ... on good internal control practices, I hear from hundreds ... how painful implementing 404 has become for their companies. ...
... officials may not be saying it, but they are frightened ... deadly avian flu virus begins quietly in scattered areas of ... on it - with substantial harm done to public health ... one that is exacerbated by the lack of an electronic ...
Cached Biology Technology:The Big Picture of SOX 404 2The Big Picture of SOX 404 3The Big Picture of SOX 404 4UW compound counters Avian flu 2UW compound counters Avian flu 3
(Date:7/29/2014)... study from UC San Francisco is the first to ... overtime and accelerate cellular aging, these negative effects may ... sleeping well. , "The study participants who exercised, ... than the ones who didn,t maintain healthy lifestyles, even ... author Eli Puterman, PhD, assistant professor in the department ...
(Date:7/28/2014)... University of Arizona has sequenced the complete genome of ... and agriculturalists, understanding of the growing patterns of African ... rice varieties that are better able to cope with ... , The paper, "The genome sequence of African rice ... was published online in Nature Genetics on ...
(Date:7/28/2014)... have pinpointed a mechanism in part of the brain that ... it to both type 1 and type 2 diabetes. The ... Proceedings of the National Academies of Sciences . , ... a part of the hypothalamus known as the ventromedial nucleus ... glucose levels in the blood," said lead author Sabrina Diano, ...
Breaking Biology News(10 mins):Healthy lifestyle may buffer against stress-related cell aging, study says 2Generating a genome to feed the world: UA-led team sequences African rice 2Generating a genome to feed the world: UA-led team sequences African rice 3Generating a genome to feed the world: UA-led team sequences African rice 4Glucose 'control switch' in the brain key to both types of diabetes 2
... dayand starting this week, they will be part of a multinational ... mines left over from as long ago as the First and ... naval exercises in the Baltic Sea this year, where more than ... all part of a day,s work for U.S. Navy divers, who ...
... in air pollution were associated with changes in biomarkers of ... as measures of cardiovascular physiology in healthy young persons, according ... JAMA, a theme issue on Global Health. ... but the mechanisms by which air pollution leads to CVD ...
... A review of studies reporting estimates of the ... malaria over the past 20 years suggests that a ... women attending antenatal (before birth) facilities in sub-Saharan Africa, ... published in the May 16 issue of JAMA ...
Cached Biology News:Undersea warriors, undersea medicine: The future force 2Air pollution level changes in Beijing linked with biomarkers of cardiovascular disease 2Air pollution level changes in Beijing linked with biomarkers of cardiovascular disease 3Air pollution level changes in Beijing linked with biomarkers of cardiovascular disease 4Considerable prevalence of both malaria, STIs exist among pregnant women in sub-Saharan Africa 2
Multidrop DW is a high-speed automated dispenser for Deep Well plates, 1.1 ml test tubes and 96-well plates. Designed for accuracy and precision, the Multidrop DW dispenses up to eight different reag...
ma. plate stack height 70mm...
... Thermal Cycler (MBS) is a ... medium to high throughput PCR. ... latest in satellite block technology, ... control, resulting in a system ...
45° Fixed Angle Rotor for use in the IEC Centra CL2, Centra CL3/CL3R, HN-SII, and the Centra-MP4/MP4R....
Biology Products: